“…Gene expression profiling of melanoma cell lines and tumor samples has revealed the different transcriptional states that underlie the proliferative and invasive phenotypes of melanoma cells (3)(4)(5)(6)(7). While proliferative cells tend to express high levels of developmental and lineage specification genes such as MITF, MLANA, and DCT as well as SOX10 and PAX3 (1,4,6), cells with an invasive transcriptional state are marked by expression of amongst others, ZEB1, SNAI1, AXL, NGFR, SPARC, WNT5A and genes involved in TGF-β signaling (4,(6)(7)(8)(9)(10). Currently, various transcriptional regulators have been implicated as drivers of the transition towards an invasive phenotype, including BRN2, AP-1, TEAD, NFATC2, and NFIB (4,(11)(12)(13)(14).…”