The looming epidemic of diabetes-associated tuberculosis: learning lessons from HIV-associated tuberculosis

Harries, Anthony; Lin, Yan; Satyanarayana, Srinath; Lönnroth, Knut; Li, L; Wilson, Nevin; Ls, Chauhan; Zachariah, Rony; Baker, Meghan A; Jeon, Christie Y.; Murray, Megan; Maher, Dermot; Bygbjerg, Ib Christian; Enarson, Donald A.; Billo, Nils; Kapur, Anil

doi:10.5588/ijtld.11.0503

Cited by 109 publications

(104 citation statements)

References 45 publications

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“…In the contemporary South Africa envisioned in the NDP, the most important aspect to investing in MSH research would be its potential to address a key South African or African societal need which is particularly urgent for a Third World country at the confluence of an increasing burden of First World 'lifestyle' diseases like hypertension, cardiovascular and diabetes, with the Third World threats of TB and HIV. 23 MSH plays a role in the self-defensive antioxidant response of mycobacteria to an elevated oxidative intracellular environment, 24 and also a part in the detoxification mechanism of xenobiotics. Thus MSH is a druggable target in the search and development of drugs against TB, particularly new drugs to counter bacterial resistance against the current therapies.…”

Section: Mycothiol's Significance To the Tb Problemmentioning

confidence: 99%

Great South African molecules: the case for mycothiol

Nkambule

2017

S.Afr.j.chem.

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South Africa has one of the oldest chemical societies in the world and has a long history of natural products, synthetic, and medicinal chemistry yet the visibility of molecules discovered or synthesized in South Africa is very low. Is this because South African scientists are incapable of discovering influential and celebrated molecules, or is there inadequate publicity of such discoveries? Perspective profiles on the discovery and scope of research on 'Great South African Molecules' should be a good start to redress this state of affairs. One such molecule deserving publicity is the antioxidant mycothiol which is produced by mycobacteria. This is a molecule of interest not only because of its medicinal potential in the fight against tuberculosis, but also from synthetic methodology and enzyme inhibition studies. This review aims to illuminate the scope of research in mycothiol chemistry for the purpose of promoting multidisciplinary investigations related to this South African molecule.

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Section: Mycothiol's Significance To the Tb Problemmentioning

confidence: 99%

Great South African molecules: the case for mycothiol

Nkambule

2017

S.Afr.j.chem.

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“…The current resurgence of TB is mainly due to increasing incidence of resistance of M. tuberculosis strains to first-line and important second-line anti-TB drugs and the association of active TB disease with HIV co-infection or other underlying immunosuppressive conditions such as diabetes. [22,23] The WHO has developed the directly observed therapy short course (DOTS) strategy to optimize response and compliance to TB treatment.…”

Section: Introductionmentioning

confidence: 99%

Overview of Drug Resistant Mycobacterium tuberculosis

Rai¹,

Khan²

2018

IJLSSR

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“…Systemic complications are the major cause of morbidity and mortality in patients with diabetes. These complications are divided into two groups, macrovascular and microvascular complications [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Regulation of hepatic and mucosal 6-phosphofructo-1-kinase activity by trigonella foenum-graecum linn (fenugreek) seeds of streptozotocin-induced diabetic rats

Ali¹,

Zamzami²,

Khoja³

2013

J Diab Res Clin Met

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Background: Trigonella foenum-graecum Linn. (fenugreek) can ameliorate hyperglycemia and dyslipidemia, however, the detailed mechanism is unclear. The present study aims to investigate the effect of fenugreek seeds water extract (FSE) on 6-phosphofructo-1-kinase (PFK-1) activity, a key enzyme of glycolysis, in the liver and small intestine of streptozotocin induced diabetic rats and its impact on plasma glucose and lipid concentrations. Methods: 50 male Wistar rats were used in this study. The rats were divided into five groups with 10 rats in each group: normal control rats (Group1), streptozotocin-induced diabetic rats (Group2), streptozotocin-induced diabetic rats + Fenugreek seeds (0.5g/500 ml water) (Group3), streptozotocin-induced diabetic rats + Fenugreek seeds (1.0g/500 ml water) (Group4), streptozotocin-induced diabetic rats + insulin (Group5). Blood samples were then collected after the period of treatment for the analysis of glucose, total cholesterol, triacylglycerol and insulin concentration. PFK-1 for liver and intestinal mucosa was extracted and assayed. Results: Diabetic rats showed significantly lower liver and intestinal mucosa PFK-1 activities (both at P<0.05) compared with control rats. Diabetic rats treated with FSE (1.0g / 500 ml water) showed a significant (P<0.0001) increase in the PFK-1 activity of liver and intestinal mucosa by 54% and 75% respectively. The plasma glucose concentrations of diabetic rats treated with 0.5g and 1.0g fenugreek / 500 ml water were significantly (P<0.001) decreased by 32% and 43%. In addition the concentrations of plasma total cholesterol and triacylglycerol were significantly (both at P<0.0001) decreased by 57% and 42%, respectively in rats treated with 1.0g fenugreek / 500 ml water, compared with non-treated diabetic rats. Conclusions: These results may suggest that the in-vivo hypoglycaemic effect of FSE is mediated, at least in part, by the activation of PFK-1 in intestinal and liver cells.

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The looming epidemic of diabetes-associated tuberculosis: learning lessons from HIV-associated tuberculosis

Cited by 109 publications

References 45 publications

Great South African molecules: the case for mycothiol

Great South African molecules: the case for mycothiol

Overview of Drug Resistant Mycobacterium tuberculosis

Regulation of hepatic and mucosal 6-phosphofructo-1-kinase activity by trigonella foenum-graecum linn (fenugreek) seeds of streptozotocin-induced diabetic rats

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