The longitudinal study of the Northern Finland birth cohort of 1966

Rantakallio, Paula

doi:10.1111/j.1365-3016.1988.tb00180.x

Cited by 351 publications

(252 citation statements)

References 32 publications

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“…We also examined the relationship between FTO genotype and androgen levels (as a continuous trait relevant to PCOS status) in 324 of the UK cases and in 1,000 women from the population-based Northern Finland Birth Cohort of 1966 (NFBC1966, described previously [6,[19][20][21]), in whom there were available measures of both testosterone and FTO genotype. None of these women was on oral hypoglycaemic agents (including metformin) or hormonal therapy, and none was pregnant at the time of study.…”

Section: Methodsmentioning

confidence: 99%

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome

et al. 2008

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Aims/hypothesis Variants in the fat-mass and obesityassociated gene (FTO) influence susceptibility to type 2 diabetes via an effect on adiposity/obesity. Given the important role of obesity in the aetiology of both polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus, our aim was to establish whether FTO variants are also implicated in PCOS susceptibility. MethodsWe performed a genetic association study of FTO variant rs9939609 using case-control analyses, conducted in 463 PCOS patients (geometric mean BMI 27.5 kg/m 2 ) and 1,336 female controls (geometric mean BMI 25.3 kg/ m 2 ) of UK British/Irish origin. We also sought evidence for associations between FTO variation and circulating testosterone levels in 324 UK PCOS patients and 1,000 women from the Northern Finland Birth Cohort of 1966. Outcome Diabetologia (2008) [adjusted]). This association was most evident in obese PCOS patients (PCOS patients below median BMI vs UK controls, p=0.11; above median BMI vs controls, p=2.9× 10 −4 ). No relationship between FTO genotype and androgen levels was seen. Conclusions/interpretation We provide the first evidence that variants that predispose to common obesity also result in altered susceptibility to PCOS, confirming the mechanistic link between these conditions. The predominant effect of FTO variants on PCOS susceptibility is probably mediated through adiposity.

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Section: Methodsmentioning

confidence: 99%

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome

et al. 2008

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“…It consists of an unselected birth cohort of 12 058 live births, and covered 96.3% of all deliveries in Northern Finland in the year 1966. 21 All subjects are Caucasians. Data collection was begun in the antenatal phase and it has been continued since then in several ways.…”

Section: Designmentioning

confidence: 99%

Obesity and depression: results from the longitudinal Northern Finland 1966 Birth Cohort Study

et al. 2005

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Objective: To examine the association between body size and depression in a longitudinal setting and to explore the connection between obesity and depression in young adults at the age of 31 years. Design: This study forms part of the longitudinal Northern Finland 1966 Birth Cohort Study (N ¼ 12 058). The follow-up studies were performed at 14 and 31 years. Data were collected by postal inquiry at 14 years and by postal inquiry and clinical examination at 31 years. Subjects: A total of 8451 subjects (4029 men and 4422 women) who gave a written informed consent and information on depression by three depression indicators at 31 years. Measurements: Body size at 14 (body mass index (BMI) and 31 (BMI and waist-to-hip ratio (WHR)) years and depression at 31 years by three different ways: depressive symptoms by the HSCL-25-depression questionnaire (HSCL-25), the use of antidepressants and self-reported physician-diagnosed depression. Results: Obesity at 14 years associated with depressive symptoms at 31 years; among male subjects using the cutoff point 2.01 in the HSCL-25 (adjusted odds ratio (OR) 1.97, 95% CI 1.06-3.68), among female subjects using the cutoff point 1.75 (adjusted OR 1.64, 95% CI 1.16-2.32). Female subjects who were obese both at baseline and follow-up had depressive symptoms relatively commonly (adjusted OR 1.40, 95% CI 1.06-1.85 at cutoff point 1.75); a similar association was not found among male subjects. The proportion of those who used antidepressants was 2.17-fold higher among female subjects who had gained weight compared to female subjects who had stayed normal-weighted (adjusted OR 2.17, 95% CI 1.28-3.68). In the crosssectional analyses male subjects with abdominal obesity (WHR X85th percentile) had a 1.76-fold risk of depressive symptoms using the cutoff 2.01 in the HSCL-25 (adjusted OR 1.76, 95% CI 1.08-2.88). Abdominally obese male subjects had a 2.07-fold risk for physician-diagnosed depression (adjusted OR 2.07, 95% CI 1.23-3.47) and the proportion of those who used antidepressants was 2.63-fold higher among obese male subjects than among male subjects without abdominal obesity (adjusted OR 2.63, 95% CI 1.33-5.21). Abdominal obesity did not associate with depression in female subjects. Conclusion: Obesity in adolescence may be associated with later depression in young adulthood, abdominal obesity among male subjects may be closely related to concomitant depression, and being overweight/obese both in adolescence and adulthood may be a risk for depression among female subjects.

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“…A detailed description of the data set has been presented in several previous studies. 7 In 1997, 8463 (4389 men and 4074 women) cohort members, who were living in Northern Finland or in the capital area, were sent postal questionnaires and invited to undergo a clinical examination; 6033 (71.3 %), of which 48% were male subjects, attended. As female hormones may play an important role as confounding factors in the association between IR and depression in women, 3,8,9 and owing to the methodological limitation that our data did not include information on the female hormonal status, we based our analyses exclusively only on the 2609 men, who had consented in writing to the use of their collected data for scientific purposes.…”

Section: Study Samplementioning

confidence: 99%

Depressive symptoms and insulin resistance in young adult males: results from the Northern Finland 1966 birth cohort

et al. 2006

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The association between insulin resistance (IR) and depression is a subject of growing research interest, especially as previous population-based studies have presented conflicting findings. The present study extends our understanding about the putative impact of the severity of depressive symptoms on this association and it provides further epidemiological evidence in support of earlier findings, suggesting that the association between IR and depression is present already in young adult males. To determine the impact of the severity of depressive symptoms on the putative association between IR and depression in young adult males, we were given access to the Northern Finland 1966 Birth Cohort database. During the 31-year follow-up survey of this genetically homogeneous birth cohort, IR was assessed by 'Qualitative Insulin Sensitivity Check Index' (QUICKI), and severity of depressive symptoms by 'Hopkins' Symptom Checklist-25' (HSCL-25). This study involved 2609 male cohort members with complete variable information. In men, the means of the QUICKI-values decreased (i.e., IR increased) in line with the increased severity of depressive symptoms as assessed by HSCL-25 subgroups (analysis of covariance P-value for trend, P = 0.003). In multivariate generalized logistic regression analyses, after adjusting for confounders, IR was positively associated with current severe depressive symptoms, the odds ratio (OR) being over threefold (adjusted OR 3.15, 95% confidence interval 1.48-6.68) and the value of OR increased in parallel with a tighter definition of IR (P-value for trend = 0.007). The results indicate that in young males, a positive association exists specifically with severe depressive symptoms. Molecular Psychiatry (2006) 11, 929-933.

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The longitudinal study of the Northern Finland birth cohort of 1966

Cited by 351 publications

References 32 publications

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome

Obesity and depression: results from the longitudinal Northern Finland 1966 Birth Cohort Study

Depressive symptoms and insulin resistance in young adult males: results from the Northern Finland 1966 birth cohort

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