The longitudinal effects of seated isometric yoga on blood biomarkers, autonomic functions, and psychological parameters of patients with chronic fatigue syndrome: a pilot study

Oka, Takahiro; Tanahashi, Tokusei; Lkhagvasuren, Battuvshin; Yamada, Yuichi

doi:10.1186/s13030-019-0168-x

Cited by 11 publications

(10 citation statements)

References 72 publications

(121 reference statements)

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“…We demonstrated that regular practice of recumbent isometric yoga reduced the CFQ 11 scores of patients with ME/CFS. Several studies have already suggested the beneficial effects of yoga, although the type of yoga was different from that used in our studies, in at least a subset of patients with ME/CFS [4–6, 19] [46]. In a case report of one patient with CFS, yoga-based lifestyle intervention improved their clinical profile, positive aspects of personality, and subjective well-being, in addition to reducing anxiety [4].…”

Section: Discussionmentioning

confidence: 85%

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study

Takakura¹,

Oka²,

Sudo³

2019

BioPsychoSocial Med

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Background: Yoga is a representative mind-body therapy. Our previous studies have demonstrated that isometric yoga (i.e. yoga programs that we developed so individuals can practice yoga poses with a self-adjustable isometric load) reduces the fatigue of patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, the underlying mechanisms remain unclear. Several studies have suggested that the micro-ribonucleic acid (miRNA) expression of ME/CFS patients is different from that of healthy subjects. However, it has not to date been determined if the practice of isometric yoga can affect miRNA expression. Therefore, we sought to investigate if isometric yoga is associated with changes in the expression levels of serum miRNA of patients with ME/CFS. Methods:The study included nine patients with ME/CFS who failed to show satisfactory improvement after at least 6 months of treatment administered at our hospital. Patients practiced recumbent isometric yoga for 3 months; they met with a yoga instructor every 2 to 4 weeks and participated in daily in-home sessions. The effect of recumbent isometric yoga on fatigue was assessed by comparing pre-and post-intervention scores on the Japanese version of the 11-item Chalder fatigue scale (CFQ 11). Patient blood samples were drawn pre-and postintervention, just prior to practicing recumbent isometric yoga with an instructor. The serum was used for miRNA array analysis with known human miRNAs.Results: The average CFQ 11 score decreased significantly (from 25.3 ± 5.5 to 17.0 ± 5.8, p < 0.0001) after practicing recumbent isometric yoga for 3 months. The miRNA microarray analysis revealed that four miRNAs were significantly upregulated, and 42 were downregulated after the intervention period.Conclusions: This explorative pilot study is the first to demonstrate changes in the serum levels of several miRNAs after regular practice of recumbent isometric yoga. These miRNAs might represent biomarkers for the fatiguerelieving effects of isometric yoga of patients with ME/CFS.

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Section: Discussionmentioning

confidence: 85%

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study

Takakura¹,

Oka²,

Sudo³

2019

BioPsychoSocial Med

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“…Eight studies measured anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) [ 29 , 30 , 40 , 41 , 43 , 44 , 51 , 91 ]. Six studies measured quality of life or physical and/or mental functioning using different quality of life outcome measures [ 28 , 29 , 30 , 41 , 45 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…Six studies measured quality of life or physical and/or mental functioning using different quality of life outcome measures [ 28 , 29 , 30 , 41 , 45 , 51 ]. Seven studies measured objective outcomes including ventilatory parameters [ 38 ], performance testing by computer programs [ 51 ], telomerase activity [ 70 ], autonomic nervous system functions, blood biomarkers [ 42 , 91 ], adiponectin levels [ 83 ], and microRNA changes [ 10 ]. Table 2 describes the details of these outcome measures and the other outcomes measured in the included studies.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Mind-Body Interventions to Treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

et al. 2021

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Background and Objectives: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic condition distinguished by disabling fatigue associated with post-exertional malaise, as well as changes to sleep, autonomic functioning, and cognition. Mind-body interventions (MBIs) utilize the ongoing interaction between the mind and body to improve health and wellbeing. Purpose: To systematically review studies using MBIs for the treatment of ME/CFS symptoms. Materials and Methods: MEDLINE, EMBASE, CINAHL, PsycINFO, and Cochrane CENTRAL were searched (inception to September 2020). Interventional studies on adults diagnosed with ME/CFS, using one of the MBIs in comparison with any placebo, standard of care treatment or waitlist control, and measuring outcomes relevant to the signs and symptoms of ME/CFS and quality of life were assessed for inclusion. Characteristics and findings of the included studies were summarized using a descriptive approach. Results: 12 out of 382 retrieved references were included. Seven studies were randomized controlled trials (RCTs) with one including three reports (1 RCT, 2 single-arms); others were single-arm trials. Interventions included mindfulness-based stress reduction, mindfulness-based cognitive therapy, relaxation, Qigong, cognitive-behavioral stress management, acceptance and commitment therapy and isometric yoga. The outcomes measured most often were fatigue severity, anxiety/depression, and quality of life. Fatigue severity and symptoms of anxiety/depression were improved in nine and eight studies respectively, and three studies found that MBIs improved quality of life. Conclusions: Fatigue severity, anxiety/depression and physical and mental functioning were shown to be improved in patients receiving MBIs. However, small sample sizes, heterogeneous diagnostic criteria, and a high risk of bias may challenge this result. Further research using standardized outcomes would help advance the field.

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“…As described earlier, these types of yoga programs would enable participants to obtain post-isometric relaxation and to enhance self-awareness, which may help them nd methods for coping with their stress. Furthermore, this style enables [28] people with debilitating diseases to participate in and reap the bene ts of yoga [9][10][11][12][13]. Due to these characteristics, the classes in the present study were more therapeutic rather than being designed to improve physical tness or personal appearance.…”

Section: Limitationsmentioning

confidence: 99%

“…A considerable number of studies have demonstrated that yoga has health-related bene ts in healthy individuals such as reductions of negative affect, perceived stress, and subjective somatic symptoms, as well as improvement in health-related quality of life [1][2][3]. Furthermore, cumulative studies have suggested that yoga also has bene cial effects for patients with stress-related diseases such as depressive disorders [4,5] and those with chronic illnesses such as breast cancer [6][7][8] and myalgic encephalomyelitis/chronic fatigue syndrome [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Health-related benefits and adverse events associated with yoga classes among subjects that are healthy, in poor health, or with chronic diseases.

Oka

2020

Preprint

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Background: Our previous study demonstrated that 42% of yoga class participants in Japan had chronic diseases that required medication. This raises the question as to whether those with chronic diseases could benefit from practicing yoga or if they are at higher risk for specific adverse events compared to healthy individuals receiving the same instruction. Methods: To address these questions, 328 adults who started practicing yoga for the first time were asked to complete the Profile of Mood States (POMS), Perceived Stress Scale (PSS), and Medical Outcomes Study Short Form 8, standard version (SF-8TM) and to record any adverse events on the first day of the yoga class and again three months later. The participants consisted of three groups: a healthy (H) group (n=70), a poor health (PH) group (n=117), and a chronic disease (CD) group (n=141). The severity of subjective symptoms was also compared between the pre- and post-intervention period in the PH and CD groups.Results: Typically, yoga classes were held once a week for 60-90 min. The programs included asanas, pranayamas, meditation, isometric yoga and sukshma vyayama. In the PH and CD groups, the POMS tension-anxiety and fatigue scores decreased and the vigor score increased significantly after the first class. Furthermore, PSS scores decreased and the SF-8TM scores increased significantly three months later. The severity of subjective symptoms such as easy fatigability, shoulder stiffness, and insomnia also decreased over three months. Individuals in these groups experienced more frequent adverse events than those in the H group. The PH and CD groups also experienced a greater variety of symptoms, including psychological ones, not reported by the H group. Adverse events were not so serious that subjects stopped practicing yoga during the class. About 60% of all participants were highly satisfied with participating in yoga classes.Conclusions: If yoga classes are conducted with attention to possible adverse events, yoga practice in a studio may have beneficial effects for people with functional somatic symptoms and chronic diseases, as well as healthy subjects. These benefits include reductions in perceived stress and uncomfortable symptoms as well as improved mood and quality of life.

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The longitudinal effects of seated isometric yoga on blood biomarkers, autonomic functions, and psychological parameters of patients with chronic fatigue syndrome: a pilot study

Cited by 11 publications

References 72 publications

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study

Systematic Review of Mind-Body Interventions to Treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Health-related benefits and adverse events associated with yoga classes among subjects that are healthy, in poor health, or with chronic diseases.

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