The longitudinal effect of the atherogenic index of plasma on type 2 diabetes in middle-aged and older Chinese

Qian, Yi; Ren, Ziyang; Bai, Guannan; Zhu, Siyu; Li, Shuting; Li, Chunlu; Wu, Hongjiang; Zhu, Yimin; Song, Peige

doi:10.1007/s00592-021-01801-y

Cited by 21 publications

(14 citation statements)

References 19 publications

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“…36,37 The development of T2DM can be predicted by the AIP index. 38,39 Additionally, AIP was significantly correlated with the prevalence of NAFLD in both the obese and nonobese populations. 40,41 On the basis of past research and the current data, it can be inferred that there is also a favorable correlation between AIP and NAFLD in patients with T2DM.…”

Section: Discussionmentioning

confidence: 93%

A Cross-Sectional Study of the Correlation Between the Atherogenic Index of Plasma and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

Lin¹,

Li²,

Wan³

2022

DMSO

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Purpose The main objective of this study was to examine the possible association between the atherogenic index of plasma (AIP) and the prevalence of nonalcoholic fatty liver disease (NAFLD) in Chinese individuals with type 2 diabetes mellitus (T2DM). Patients and methods In this survey, data from 1074 patients with T2DM were retrospectively extracted. The correlations between each variable and NAFLD were determined by univariate analysis, and then, the statistically significant variables were evaluated for their association with AIP and NAFLD by multivariate regression analysis. Results AIP levels were significantly higher in all males and females with NAFLD than those without NAFLD (p<0.001). The prevalence of NAFLD increased progressively throughout the AIP quartiles (trend P < 0.001) and accounted for possible variables in Model 3 of the multivariate logistic regression analysis (OR: 2244.984). In terms of sensitivity and specificity, the AIP index was found to be 65.0% and 90.1% accurate, respectively, with a 95% CI of 0.804–0.893. According to a stratified analysis, females, patients over the age of 56 and current nonsmokers were found to have a higher chance of developing NAFLD. Conclusion T2DM individuals with NAFLD were found to have a higher AIP index than those without NAFLD. The prevalence and progression of NAFLD in T2DM patients may be influenced by the AIP index.

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Section: Discussionmentioning

confidence: 93%

A Cross-Sectional Study of the Correlation Between the Atherogenic Index of Plasma and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

Lin¹,

Li²,

Wan³

2022

DMSO

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“…Second, although our study covered as many confounding factors as possible, there were other factors not included, such as variables reflecting diet, income, physical activity, and so forth. Third, the definition of famine severity remains controversial, as previous studies have applied cohort size shrinkage indices 30 . Moreover, although this study controlled for age between groups, it could not adjust for the potential influence of the time interval between the two cross‐sectional studies.…”

Section: Discussionmentioning

confidence: 96%

Associations of concurrent early‐life famine exposure and adulthood obesity with type 2 diabetes mellitus in middle‐aged Chinese

Yi,

Wu,

Shen

et al. 2023

Journal of Diabetes

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BackgroundEvidence has shown that early‐life famine exposure and obesity in adulthood are independently associated with the risk of type 2 diabetes mellitus (T2DM). However, few studies had revealed the combined effect of these risk factors.MethodsTwo sets of groups from the China Health and Retirement Longitudinal Study (CHARLS) were selected. The fetal‐exposure group born in 1959–1961 from 2011 wave (N = 958) and nonexposure group born in 1963–1965 from 2015 wave (N = 1540) were selected as Comparison 1. The early childhood‐exposure group born in 1955–1957 from 2011 wave (N = 1510) and fetal‐exposure group born in 1959–1961 from 2015 wave (N = 943) were Comparison 2. Logistic regressions were applied to examine the associations of different famine exposure periods and obesity patterns with T2DM risk.ResultsCompared with nonexposed participants without central overweight/obesity in adulthood, central overweight/obesity in adulthood together with nonexposure (odds ratio [OR]: 1.89, 95% confidence interval [CI]: 1.19–3.00) or fetal‐exposure (OR: 1.99, 95% CI: 1.23–3.23) was associated with higher risks of T2DM. Compared with the early childhood‐exposure group, the fetal‐exposed participants showed higher risks of T2DM (OR: 1.30, 95% CI: 1.02–1.66). The coexistence of fetal famine exposure and central overweight/obesity in adulthood was associated with higher risks of T2DM (OR: 1.82, 95% CI: 1.19–2.79). Consistent associations were observed among males and participants from less severely affected areas.ConclusionsIn conclusion, central overweight/obesity in adulthood is associated with the increased risk of T2DM, but the effect of early‐life famine exposure is not very clear.

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“…The data in this study were collected from a randomized, double-blind, multi-centre, placebo-controlled clinical trials in which patients with T2D were considered, and higher AIP values at baseline may have an impact on the results. Two prospective cohort studies in China showed that AIP was signi cantly associated with T2D in middle-aged and elderly people [6,27]. An 8-year prospective cohort study in Turkish population also found that high AIP, as a proxy for small LDL particle size, independently predicted obesity-mediated T2D in both men and women [28].…”

Section: Discussionmentioning

confidence: 99%

“…However, blood samples were taken after fasting, which may improve results, but further research is needed to determine the effect of diet on the ndings. In addition, some surveys have shown that longitudinal changes in AIP may have a potential predictive value for T2D [27].Therefore, the role of the combination of baseline and variability of AIP in the development of IR and T2D needs to be further investigated in future studies.…”

Section: Limitations and Strengthsmentioning

confidence: 99%

Association of atherogenic index of plasma with insulin resistance and type 2 diabetes: A cross-sectional study from the NHANES

Bei

Xia

et al. 2023

Preprint

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Background Atherogenic index of plasma (AIP) plays an important role in predicting the occurrence of cardiovascular events and metabolic diseases. However, the relationship between AIP and insulin resistance (IR) are limited and controversial. Therefore, we aimed to clarify the relationship of AIP with IR and type 2 diabetes (T2D). Methods This cross-sectional study Based on the data of the National Health and Nutrition Survey (NHANES) from 2009 to 2018. Weighted multivariate linear regression, weighted multivariate logistic regression, subgroup analysis, generalized additive model, smooth curve fitting and two-part logistic regression were adopted to reveal the relationship between AIP and IR, T2D and its risk markers. Results A total of 9,245 patients were enrolled. After adjusting the potential confounders, AIP was positively correlated with FBG [β = 0.85 (95%CI: 0.66, 1.05)], HbA1c [β = 0.48 (95%CI: 0.39, 0.58)], FSI [β = 47.74 (95%CI: 41.42, 54.07)] and HOMA-IR [β = 2.39 (95%CI: 1.97, 2.82)]. Overall, there was a significant positive association between the AIP and IR [OR = 15.80 (95%CI: 11.44, 21.80)] and T2D [OR = 7.18 (95%CI: 5.21, 9.917)]. However, there was a significant interaction in the gender subgroup (IR: P for interaction = 0.0135; T2D: P for interaction = 0.0024) and smoking subgroup (IR: P for interaction = 0.0130). A reverse L-shaped association was found between AIP and IR, with a turning point of 0.45. Before the turning point, the OR (95% CI) was 13.15 (10.45, 16.55). A J-shaped association was found between AIP and T2D, with a turning point of -0.47. Before the turning point, the OR (95%CI) was 5.39(4.21, 6.89). Conclusions This study indicated that AIP exhibited an positive correlation with the risk markers of T2D (FBG, HbA1c, FSI and HOMA-IR). AIP is related to the increased risk of IR, and this relationship follows a reverse L-shaped curve. AIP is related to the increased risk of T2D, and this relationship follows a J-shaped curve.

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The longitudinal effect of the atherogenic index of plasma on type 2 diabetes in middle-aged and older Chinese

Cited by 21 publications

References 19 publications

A Cross-Sectional Study of the Correlation Between the Atherogenic Index of Plasma and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

A Cross-Sectional Study of the Correlation Between the Atherogenic Index of Plasma and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

Associations of concurrent early‐life famine exposure and adulthood obesity with type 2 diabetes mellitus in middle‐aged Chinese

Association of atherogenic index of plasma with insulin resistance and type 2 diabetes: A cross-sectional study from the NHANES

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