The Longitudinal Aging Study Amsterdam: cohort update 2016 and major findings

Hoogendijk, Emiel O.; Deeg, Dorly J. H.; Poppelaars, Jan; Horst, Marleen van der; Groenou, M.I. Broese Van; Comijs, Hannie C.; Pasman, H. Roeline W.; Schoor, Natasja M. van; Suanet, Bianca; Thomése, Fleur; Tilburg, T.G. van; Visser, Marjolein; Huisman, Martijn

doi:10.1007/s10654-016-0192-0

Cited by 178 publications

(176 citation statements)

References 154 publications

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“…Because a Dutch FRAX tool was not available at the start of the study, the UK version of the FRAX was used with cut‐off values derived from the data from a representative sample of Dutch older persons (Table ) . Age‐dependent treatment cut‐offs were applied to avoid counterintuitive clinical practice whereby almost all participants of 80 years and older would have an indication for anti‐osteoporosis medication at low treatment thresholds and only few participants of 70 years and younger at higher thresholds.…”

Section: Methodsmentioning

confidence: 99%

The Effect of a Screening and Treatment Program for the Prevention of Fractures in Older Women: A Randomized Pragmatic Trial

Merlijn

Swart

Schoor

et al. 2019

Journal of Bone and Mineral Research

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Population screening for fracture risk may reduce the fracture incidence. In this randomized pragmatic trial, the SALT Osteoporosis Study (SOS), we studied whether screening for fracture risk and subsequent treatment in primary care can reduce fractures compared with usual care. A total of 11,032 women aged 65 to 90 years with ≥1 clinical risk factor for fractures were individually randomized to screening (n = 5575) or usual care (n = 5457). Participants in the screening group underwent a screening program, including bone densitometry and vertebral fracture assessment. Participants with a high 10‐year fracture probability (FRAX) or a vertebral fracture were offered treatment with anti‐osteoporosis medication by their general practitioner. Incident fractures as reported by questionnaires were verified with medical records. Follow‐up was completed by 94% of the participants (mean follow‐up = 3.7 years). Of the 5575 participants in the screening group, 1417 (25.4%) had an indication for anti‐osteoporosis medication. Screening and subsequent treatment had no statistically significant effect on the primary outcome fracture (hazard ratio [HR] = 0.97; 95% confidence interval [CI] 0.87–1.08), nor on the secondary outcomes osteoporotic fractures (HR = 0.91; 95% CI 0.81–1.03), major osteoporotic fractures (HR = 0.91; 95% CI 0.80–1.04), hip fractures (HR = 0.91; 95% CI 0.71–1.15), falls (odds ratio [OR] = 0.91; 95% CI 0.72–1.15), or mortality (HR = 1.03; 95% CI 0.91–1.17). Post hoc explorative finding suggested that screening might be most effective after a recent fracture (HR = 0.65; 95% CI 0.44–0.96 for major osteoporotic fractures and HR = 0.38; 95% CI 0.18–0.79 for hip fractures). The results of this study might have been compromised by nonparticipation and medication nonadherence in the screening group. Overall, this study does not provide sufficient indications to consider screening for fracture prevention. However, we cannot exclude its clinical relevance to reduce (major) osteoporotic fractures and hip fractures because of the relatively small number of women with a treatment indication in the intervention group. © 2019 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals, Inc.

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Section: Methodsmentioning

confidence: 99%

The Effect of a Screening and Treatment Program for the Prevention of Fractures in Older Women: A Randomized Pragmatic Trial

Merlijn

Swart

Schoor

et al. 2019

Journal of Bone and Mineral Research

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“…For the present study, data were collected within the Longitudinal Aging Study Amsterdam (LASA), an ongoing interdisciplinary, longitudinal cohort study on the predictors and consequences of changes in physical, cognitive, emotional and social functioning in older men and women (20,21,22). From the population registers of 11 municipalities in three regions in the Netherlands, a random sample was drawn of over 3000 communitydwelling older men and women, 55-85 years of age, stratified by age and sex and weighted according to expected 5-year mortality.…”

Section: Study Populationmentioning

confidence: 99%

The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women

Nieuwpoort

Vlot

Schaap

et al. 2018

European Journal of Endocrinology

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“…The following cohorts studies are included in the MooDFOOD project: the Longitudinal Aging Study Amsterdam ( LASA ) (Hoogendijk et al . ), the NEtherlands Study on Depression and Anxiety ( NESDA ) (Penninx et al . ), the HEalthy Life In an Urban Setting study ( HELIUS ) (Stronks et al .…”

Section: Approachmentioning

confidence: 99%

“…Data from six prospective cohort studies will be used, representing diversity across Europe both in terms of population characteristics and differences in diet as well as the social, political and economic contexts. The following cohorts studies are included in the MooDFOOD project: the Longitudinal Aging Study Amsterdam (LASA) (Hoogendijk et al 2016), the NEtherlands Study on Depression and Anxiety (NESDA) (Penninx et al 2008), the HEalthy Life In an Urban Setting study (HELIUS) (Stronks et al 2013), the Whitehall II study (WHITEHALL II) Figure 1 Conceptual model forming the basis of the MooDFOOD project. (Marmot & Brunner 2005), the Invecchiare in Chianti study (INCHIANTI) (Ferrucci et al 2000), and the Age, Gene/Environment Susceptibility study (AGES) (Harris et al 2007).…”

Section: Approachmentioning

confidence: 99%

The MooDFOOD project: Prevention of depression through nutritional strategies

2017

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MooDFOOD is a 'Multi-country cOllaborative project on the rOle of Diet, Food-related behaviour, and Obesity in the prevention of Depression'. Depression is one of the most prevalent, severe and disabling disorders in the European Union (EU) and places a heavy burden on individuals and families. A large proportion of the EU population is overweight, which increases depression risk. Targeting food-related behaviours and nutritional status of people prone to overweight and obesity offers opportunities to prevent depression. The MooDFOOD consortium combines expertise in nutrition, consumer behaviour, psychiatry and preventive health psychology and uses a unique integrative approach. Existing high quality data from longitudinal prospective European cohort studies will be combined with new data from surveys, short-term experiments and a long-term preventive intervention study. This approach will provide insight into the causality of the link between diet and depression, and underlying pathways; it will also identify which modifications related to diet and dietary behaviour lead to beneficial changes in depression risk and lower the environmental burden of the diet. Knowledge of all these aspects will be used to develop novel nutritional strategies to prevent depression. In close collaboration with stakeholders and experts, MooDFOOD will transform the identified nutritional strategies into guidelines and practical tools to guide policy at EU and Member State levels. Promotion of the findings through extensive European networks will help to lower the risk of depression and contribute to overall health of all EU citizens.

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The Longitudinal Aging Study Amsterdam: cohort update 2016 and major findings

Cited by 178 publications

References 154 publications

The Effect of a Screening and Treatment Program for the Prevention of Fractures in Older Women: A Randomized Pragmatic Trial

The Effect of a Screening and Treatment Program for the Prevention of Fractures in Older Women: A Randomized Pragmatic Trial

The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women

The MooDFOOD project: Prevention of depression through nutritional strategies

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