2002
DOI: 10.1001/archderm.138.8.1079
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The Longevity of a Bilayered Skin Substitute After Application to Venous Ulcers

Abstract: Background: A bilayered skin substitute composed of allogeneic keratinocytes and fibroblasts in a collagen gel has been approved by the US Food and Drug Administration for the treatment of venous and diabetic ulcers. Its mechanism of action has not been fully determined. Objective: To determine the longevity of allogeneic fibroblasts and keratinocytes in a bilayered skin substitute in patients with venous leg ulcers. Methods: Ten patients with venous leg ulcers were treated with a bilayered skin substitute on … Show more

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Cited by 102 publications
(67 citation statements)
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“…The latter do not engraft, but rather survive for a limited time, presumably releasing growth factors, synthesizing matrix, and recruiting endogenous stem cells. 30,31 Mesenchymal stem cells, found primarily not only in the bone marrow but also in adipose, vascular, muscle, and dermal tissue, are a highly active topic of research because of their ability to differentiate into multiple connective tissues, such as bone, cartilage, muscle, bone marrow stroma, tendon/ligament, fat, and dermis. 32 Furthermore, these cells secrete numerous immunoregulatory and regenerative molecules.…”
Section: Cellsmentioning
confidence: 99%
“…The latter do not engraft, but rather survive for a limited time, presumably releasing growth factors, synthesizing matrix, and recruiting endogenous stem cells. 30,31 Mesenchymal stem cells, found primarily not only in the bone marrow but also in adipose, vascular, muscle, and dermal tissue, are a highly active topic of research because of their ability to differentiate into multiple connective tissues, such as bone, cartilage, muscle, bone marrow stroma, tendon/ligament, fat, and dermis. 32 Furthermore, these cells secrete numerous immunoregulatory and regenerative molecules.…”
Section: Cellsmentioning
confidence: 99%
“…As measured by in situ hybridization for donor cell Y-chromosome, the allogeneic cells persisted in female recipients for only approximately four weeks [85][86][87]. Reports concerning cell persistence [85,87] were contrary to the published academic experience, but eventually it was understood that histologic constructions are not necessary because the cells begin to die very soon after application [88]. Any barrier or water loss function provided by the engineered tissues is very short lived.…”
Section: Allogeneic Cell Approachesmentioning
confidence: 99%
“…22,23 However, clinical findings with BSS therapies suggest that cultured skin tissue is unlikely to be acutely rejected in humans. [24][25][26][27][28] Skin substitutes are gradually replaced by the patient's skin with no excessive inflammation or other signs of acute rejection. [25][26][27][28] Finally, a limitation of all cell-based BSS therapies is the high cost of manufacturing.…”
Section: Experimental Model: Advantages and Limitationsmentioning
confidence: 99%
“…[24][25][26][27][28] Skin substitutes are gradually replaced by the patient's skin with no excessive inflammation or other signs of acute rejection. [25][26][27][28] Finally, a limitation of all cell-based BSS therapies is the high cost of manufacturing. However, this may be counterbalanced by an improved wound healing timeline, which would result in shorter patient hospitalization.…”
Section: Experimental Model: Advantages and Limitationsmentioning
confidence: 99%