The longer term effect of pulsed radiofrequency for neuropathic pain

Abstract

Pulse radiofrequency has been recently described as a technique to apply a relatively high voltage near a nerve but without the usual effects of a rise in temperature or subsequent nerve injury. In this set of case reports, the effect of pulsed radiofrequency (PRF) is described in patients with neuropathic pain syndromes which have been poorly controlled with other oral and invasive treatments. Whilst anecdotal, the results have been remarkable and should encourage further research into this technique. Observations from the basic science tend to support the concept that PRF may induce some sort of long-term depression in the spinal cord.

The role of radiofrequency in the treatment of mechanical pain of spinal origin

“…Our complications rate was quite high in comparison with that of other authors if we include the post-procedural discomfort as a complication [11]. However, these complications were all minor and resolved in a short time period (less than 1 month) after the procedure.…”

Evaluation of Pulsed Radiofrequency Denervation in the Treatment of Chronic Facetjoint Pain: An Observational Study

“…Clinical data on the efficacy of PRF are limited, whereas there is a stronger evidence for CRF, not only with respect to pain relief but also in terms of functional restoration (21)(22)(23)(24)(25). Additionally, most reports are retrospective in nature and have involved only small patient groups.…”

Radiofrequency Treatments for Neuropathic Pain: Review and New Approaches

“…Munglani (Munglani, 1999) suggested that PRF works in a manner similar to TENS, activating both spinal and supraspinal mechanisms that may decrease sensory perception. Nerve stimulation at 1-2 Hz was shown to induce long-term depression (LTD) of synaptic transmission in the spinal cord (Pockett, 1995, Sandkühler et al, 1997.…”