The long-term use of garlic in ischemic heart disease An appraisal

Arora, Ramesh; Arora, Sunita; Gupta, Raj K.

doi:10.1016/0021-9150(81)90036-8

Cited by 36 publications

(17 citation statements)

References 4 publications

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“…Bordia also reported that chronic (3 weeks to 3 months) administration of garlic oil (dose: equivalent to 1 gm/kg of fresh garlic) increased FA significantly ranging from 36% to 130% in healthy as well as acute myocardial infarction patients [49-52]. Some other investigators also found the same results [53-55]. Dried garlic powder has been also tested for its fribinolytic activity.…”

Section: Fibrinolytic Activitymentioning

confidence: 83%

“…Raw garlic, garlic oil and other extract of garlic have been shown to inhibit platelet aggregation in in vitro induced by ADP, collagen, arachidonate, epinephrine and calcium ionophore [57,61,73-75]. Chronic intake of garlic powder and garlic oil also inhibits platelet aggregation [28,50,55,76-79]. Single dose of garlic has also been shown to inhibit platelet aggregation [54,56,80].…”

Section: Platelet Aggregationmentioning

confidence: 99%

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Effect of garlic on cardiovascular disorders: a review

Banerjee

Maulik

2002

Nutr J

493

318

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Abstract

Garlic and its preparations have been widely recognized as agents for prevention and treatment of cardiovascular and other metabolic diseases, atherosclerosis, hyperlipidemia, thrombosis, hypertension and diabetes. Effectiveness of garlic in cardiovascular diseases was more encouraging in experimental studies, which prompted several clinical trials. Though many clinical trials showed a positive effect of garlic on almost all cardiovascular conditions mentioned above, however a number of negative studies have recently cast doubt on the efficary of garlic specially its cholesterol lowering effect of garlic. It is a great challenge for scientists all over the world to make a proper use of garlic and enjoy its maximum beneficial effect as it is the cheapest way to prevent cardiovascular disease. This review has attempted to make a bridge the gap between experimental and clinical study and to discuss the possible mechanisms of such therapeutic actions of garlic.

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Section: Fibrinolytic Activitymentioning

confidence: 83%

Section: Platelet Aggregationmentioning

confidence: 99%

Effect of garlic on cardiovascular disorders: a review

Banerjee

Maulik

2002

Nutr J

493

318

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Abstract

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“…[36][37][38] Since ROS have been implicated in mediating various pathological processes (e.g., ischemic heart disease, peripheral arterial occlusive disease, hypertension, hyperlipidemia, and toxicities), it can be suggested that the beneficial effects of garlic in these conditions may be due to its antioxidant activity. [39][40][41][42][43][44][45][46] The compounds in garlic (S-allylcysteine, S-allyl-mercapto cysteine, S-allyl-cysteine sulfoxide, and allicin), through their radical scavenging abilities, have been suggested to be responsible for its preventive effects against oxidative injury. 14 Diallyldisulfide (DADS), a metabolite of allicin, includes redoxactive sulfhydryl (SH)-or disulfide (-S-S)-groups which have already been proven to act as radical scavengers.…”

Section: Discussionmentioning

confidence: 99%

Garlic Extract Ameliorates Renal and Cardiopulmonary Injury in the Rats with Chronic Renal Failure

et al. 2011

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Chronic renal failure (CRF) is associated with oxidative stress that promotes production of reactive oxygen species and cytokine release. We aimed to investigate the possible protective and antioxidant effects of aqueous garlic extract (AGE) in a rat model of CRF. Male Sprague-Dawley rats were randomly assigned as either CRF group with 5/6 reduction in the renal mass or sham-operated control group. CRF group received either saline or AGE (250 mg/kg/day/1 mL) orally for 3 weeks. At the end of the 3 weeks, rats were decapitated and trunk blood was collected. Creatinine, blood urea nitrogen (BUN) and lactate dehydrogenase (LDH) activity, and TNF-α and IL-1β levels were measured in the serum samples, while malondialdehyde (MDA), glutathione (GSH) levels, and myeloperoxidase (MPO) activity were determined in the kidney, lung, and heart samples. CRF caused significant decreases in tissue GSH, which were accompanied with significant increases in MDA levels and MPO activities, while the circulating levels of the LDH activity, creatinine, BUN, TNF-α, and IL-1β were elevated. AGE treatment alleviated CRF-induced oxidative changes in the injured tissues, while CRF-induced elevations in the blood levels of the pro-inflammatory cytokines and LDH were reduced. In conclusion, CRF-induced oxidative tissue injury occurs via the activation of pro-inflammatory mediators and by neutrophil infiltration into tissues and that the protective effects of garlic on CRF-induced injury can be attributed to its ability to inhibit neutrophil infiltration and pro-inflammatory mediators. These findings suggest that garlic, as a supplementary to diet, may have a potential therapeutic use in delimitating the systemic oxidant effects of CRF on remote organs.

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“…Since reactive oxygen metabolites (ROM), or free radicals, have been implicated in mediating various pathological processes such as ischemic heart disease [5], peripheral arterial occlusive disease [6], hypertension [7], hyperlipidemia [8] and drug-or chemical-induced toxicities [9 -12], it is possible to suggest that the beneficial effects of garlic in these conditions may be due to its antioxidant activity [13]. However, the degree of antioxidative efficacy of various garlic preparations was shown to differ according to variations in the chemical structures and standardization procedures [14].…”

Section: Introductionmentioning

confidence: 99%

Role of garlic in the prevention of ischemia‐reperfusion injury

Şener¹,

Şakarcan

Yeğen

2007

Molecular Nutrition Food Res

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Garlic in different forms has antioxidant properties. These properties are shown to be due to the existence of compounds such as water soluble organosulfur compounds, S-allylcysteine and lipid soluble compounds like diallyl sulfide. The in vivo and in vitro ischemia reperfusion studies showed that prophylactic administration of aqueous garlic prior to ischemia reperfusion inhibit lipid peroxidation and prevent depletion in glutathione through its compounds that led to functional recovery. Its ability to inhibit neutrophil migration could suppress fibrosis formation. These preventive effects are seen in models that studied organs such as kidney and liver with functional recovery. Organ system specific activity such as angiotensin converting enzyme-inhibiting activity contributes to a cardioprotective and blood pressure lowering effect. Future studies should focus on post ischemia reperfusion administration of garlic to explore its rescue potential rather than prophylactic impact. Bench research findings should be translated into clinical use through human studies.

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The long-term use of garlic in ischemic heart disease An appraisal

Cited by 36 publications

References 4 publications

Effect of garlic on cardiovascular disorders: a review

Effect of garlic on cardiovascular disorders: a review

Garlic Extract Ameliorates Renal and Cardiopulmonary Injury in the Rats with Chronic Renal Failure

Role of garlic in the prevention of ischemia‐reperfusion injury

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