The long-term sequelae of traumatic brain injury over 10 years of follow-up—a matched cohort study based on routine data of a statutory health insurance carrier

Rickels, E.; Steudel, Wolf-Ingo; Repschläger, Uwe; Schulte, Claudia; Weissgärber, Harald; Wende, Danny

doi:10.3238/arztebl.m2023.0046

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Studies comparing outcomes of treatment at pediatric trauma centers versus adult trauma centers show lower mortality rates and improved functional outcomes in pediatric centers 42 . However, inconsistencies in triage criteria have led to missed diagnoses and inefficient resource use 43,44 . Child trauma survivors may face long‐term health issues like diabetes and heart disease, along with increased involvement in health, mental health, child welfare, and juvenile justice systems.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric and visual analysis of severe trauma literature in the past 20 years

Chang,

Li,

Wang

et al. 2024

MedComm – Future Medicine

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Severe trauma is a critical aspect of medical practice, profoundly impacting patient care and outcomes. Over the past 20 years, advancements in trauma care concepts and the utilization of advanced technologies have led to substantial growth in severe trauma research, evidenced by a notable increase in research activity and subsequent publications. To understand the publication landscape in severe trauma, identify prevailing research trends, and highlight areas requiring further development for future insights, we conducted a bibliometric analysis. Our analysis indicates that there are 16,939 severe trauma‐related publications from the past 20 years, with a continuous increase in publication volume, particularly showing a rapid growth trend from 2018 to 2021. The United States leads in both volume and citation frequency. Moreover, we synthesized data on productive countries/regions and research institutions, showcasing extensive collaboration across diverse geographic locations and institutional affiliations. Substantial progress has been achieved in severe trauma research, particularly in clinical diagnosis, treatment, epidemiology, prevention, and pathogenesis. However, there is still a gap in adopting cutting‐edge interdisciplinary methodologies. This study provides a comprehensive overview of the current state of severe trauma research and suggests pathways for future advancement.

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Section: Discussionmentioning

confidence: 99%

Bibliometric and visual analysis of severe trauma literature in the past 20 years

Chang,

Li,

Wang

et al. 2024

MedComm – Future Medicine

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“…Approximately 5% of incident cases and 20% of prevalent cases in the epilepsy population are considered to be due to previous TBI 11 . A German cohort study of more than 100 000 patients studied how TBI treatment intensity affected late sequalae and found an incidence rate ratio of 4.19 for severe TBI‐related PTE 24 …”

Section: Discussionmentioning

confidence: 99%

“…11 A German cohort study of more than 100 000 patients studied how TBI treatment intensity affected late sequalae and found an incidence rate ratio of 4.19 for severe TBI-related PTE. 24 PTE is a major complication of pTBI and may degrade the patient's quality of life. It is, therefore, crucial to identify those patients at risk for TBI and to consider long-term posttraumatic surveillance.…”

Section: Inclusion Criteria Exclusion Criteriamentioning

confidence: 99%

Association between pediatric traumatic brain injury and epilepsy at later ages in Finland: A nationwide register‐based cohort study

Laaksonen,

Ponkilainen,

Kuitunen

et al. 2023

Epilepsia

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ObjectiveTo examine how pediatric traumatic brain injury (pTBI) correlated with incidence of epilepsy at later ages in Finland.MethodsA nationwide retrospective register‐based cohort study from 1998 to 2018. The study group consisted of 71 969 pediatric (<18 years) patients hospitalized with TBI and a control group consisting of 64 856 pediatric patients with distal extremity fracture. Epilepsy diagnoses were gathered from the Finnish Social Insurance Institution. Kaplan‐Meier (KM) and multivariable Cox regression models were conducted to analyze the probability of epilepsy with 95% confidence intervals (CI).ResultsCumulative incidence rates (CIR) for the first 2 years were 0.5% in the pTBI group and 0.1% in the control group. The corresponding rates after 15 years of follow‐up were 1.5% in the pTBI group and 0.7% in the control group. Due to proportional hazard (PH) violations, the study population was split to the first 2 years and in subgroup analysis 4 years. During the first 2 years of surveillance, the hazard ratio (HR) for the pTBI group was 4.38 (CI: 3.39‐5.66). However, between years 2 and 20, the HR for the pTBI group was 2.02 (CI: 1.71‐2.38). A total of 337 patients (0.47%) underwent neurosurgery and 36 (10.7%) patients subsequently developed epilepsy. The CIR for the first year after TBI were 4.5% (CI: 2.3‐6.7%) in operatively managed patients and 0.3% (CI: 0.3‐0.4%) in non‐operatively managed patients. Corresponding figures after 15 years were 12.0% (CI: 8.2‐15.8%) and 1.5% (CI: 1.4‐1.6%). During the first 4 years of surveillance, the HR for the operative pTBI group was 14.37 (CI: 9.29‐20.80) and 3.67 (CI: 1.63‐8.22) between years 4 and 20.SignificancepTBI exposes patients to a higher risk for posttraumatic epilepsy (PTE) for many years after initial trauma. Children who undergo operative management for TBI have a high risk for epilepsy, and this risk was highest during the first 4 years after injury.

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Clinical complications after a traumatic brain injury and its relation with brain biomarkers

Yuguero,

Bernal,

Farré

et al. 2023

Sci Rep

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We aimed to find out which are the most frequent complications for patients who suffer a traumatic brain injury (TBI) and its relation with brain biomarker levels. We conducted a hospital cohort study with patients who attended the Hospital Emergency Department between 1 June 2018 and 31 December 2020. Different variables were collected such as biomarkers levels after 6 h and 12 h of TBI (S100, NSE, UCHL1 and GFAP), clinical and sociodemographic variables, complementary tests, and complications 48 h and 7 days after TBI. Qualitative variables were analysed with Pearson’s chi-square test, and quantitative variables with the Mann–Whitney U test. A multivariate logistic regression model for the existence of complications one week after discharge was performed to assess the discriminatory capacity of the clinical variables. A total of 51 controls and 540 patients were included in this study. In the TBI group, the mean age was 83 years, and 53.9% of the patients were male. Complications at seven days were associated with the severity of TBI (p < 0.05) and the number of platelets (p = 0.016). All biomarkers except GFAP showed significant differences in their distribution of values according to gender, with significantly higher values of the three biomarkers for women with respect to men. Patients with complications presented significantly higher S100 values (p < 0.05). The patient’s baseline status, the severity of the TBI and the S100 levels can be very important elements in determining whether a patient may develop complications in the few hours after TBI.

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The long-term sequelae of traumatic brain injury over 10 years of follow-up—a matched cohort study based on routine data of a statutory health insurance carrier

Cited by 3 publications

References 24 publications

Bibliometric and visual analysis of severe trauma literature in the past 20 years

Bibliometric and visual analysis of severe trauma literature in the past 20 years

Association between pediatric traumatic brain injury and epilepsy at later ages in Finland: A nationwide register‐based cohort study

Clinical complications after a traumatic brain injury and its relation with brain biomarkers

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