The long-term quality of life in patients with persistent inflammation-immunosuppression and catabolism syndrome after severe acute pancreatitis: A retrospective cohort study

Yang, Na; Li, Baiqiang; Ye, Bo; Ke, Lu; Chen, Faxi; Lu, Guotao; Jiang, Fangfang; Tong, Zhihui; Li, Jieshou

doi:10.1016/j.jcrc.2017.07.013

Cited by 21 publications

(27 citation statements)

References 28 publications

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“…Among these articles, 52 unique studies evaluated return to work in previously employed ICU survivors (figure 1, table 1, online supplementary eTable 2). 4 5 13–63 These studies included 13 retrospective16 18 23 30 33 39 42 43 47 48 52 56 62 and 39 prospective4 5 13–15 17 19–22 24–28 30–32 34–38 40 41 44–46 49–51 53–55 57–61 63 cohort studies, of which three were longitudinal follow-up within a randomised trial 4 37 59. Eleven (21%) studies included more than one follow-up time point after discharge 4 5 26 28 29 34 37 45 49 51 55 62.…”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies conducted employment assessments during either the first (2000–2004) or second (2008–2010) global economic downturns occurring during the publication period 4 32 36 46–48 50–52 55 63 64. Twenty-eight (54%) studies were conducted in Europe,15 17 18 20 22 25–27 30–36 38–42 44 48–51 58 62 63 14 (27%) in North America,4 5 13 14 16 19 23 24 28 29 37 45 52 55 60 8 (15%) in Australia/New Zealand21 43 46 47 53 54 59 61 and 2 (4%) in Asia 56 57. Nine studies (17%) evaluated return to work in survivors of ARDS 4 5 19 24 39 45 47 57 63.…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies (17%) evaluated return to work in survivors of ARDS 4 5 19 24 39 45 47 57 63. Employment evaluation occurred via in-person visit in 18 (35%) studies,18 19 21 26–29 31 36 39 43 45 50 55 57–60 63 telephone interview in 18 (35%) studies,4 5 13–15 23 30 32 34 42 46 47 49 52–54 56 61 mailed questionnaire in 15 (29%) studies16 17 20 22 24 25 33 35 37 38 40 41 44 48 51 and national database in 1 study 62. The majority of studies used ‘had returned to work’, ‘back to work’, ‘working’ or multiple phrases to describe survivors’ post-ICU employment status, and did not report the specific employment question(s) used, the timing of return to work or status of survivors who had not returned to work (ie, retirement, unemployment, disability).…”

Section: Resultsmentioning

confidence: 99%

“…Six (12%) studies provided demographic and/or ICU data specifically for the previously employed survivor subcohort 4 5 51 55 57 61–63. In addition, four (8%) studies documented death, loss to follow-up and participation refusal specifically among previously employed survivors, with rates of 3% (20 of 631), 6% (36 of 631) and 1% (6 of 631), respectively, across longitudinal follow-up 4 5 55 56. In risk of bias evaluation of the 52 observational studies, 46% did not have adequate representativeness of the exposed cohort, and 52% did not have adequate follow-up (online supplementary eTable 6, eFigure 2).…”

Section: Resultsmentioning

confidence: 99%

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Return to work after critical illness: a systematic review and meta-analysis

Kamdar

Suri

Suchyta

et al. 2019

Thorax

189

138

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BackgroundSurvivors of critical illness often experience poor outcomes after hospitalisation, including delayed return to work, which carries substantial economic consequences.ObjectiveTo conduct a systematic review and meta-analysis of return to work after critical illness.MethodsWe searched PubMed, Embase, PsycINFO, CINAHL and Cochrane Library from 1970 to February 2018. Data were extracted, in duplicate, and random-effects meta-regression used to obtain pooled estimates.ResultsFifty-two studies evaluated return to work in 10 015 previously employed survivors of critical illness, over a median (IQR) follow-up of 12 (6.25–38.5) months. By 1–3, 12 and 42–60 months’ follow-up, pooled return to work prevalence (95% CI) was 36% (23% to 49%), 60% (50% to 69%) and 68% (51% to 85%), respectively (τ2=0.55, I2=87%, p=0.03). No significant difference was observed based on diagnosis (acute respiratory distress syndrome (ARDS) vs non-ARDS) or region (Europe vs North America vs Australia/New Zealand), but was observed when comparing mode of employment evaluation (in-person vs telephone vs mail). Following return to work, 20%–36% of survivors experienced job loss, 17%–66% occupation change and 5%–84% worsening employment status (eg, fewer work hours). Potential risk factors for delayed return to work include pre-existing comorbidities and post-hospital impairments (eg, mental health).ConclusionApproximately two-thirds, two-fifths and one-third of previously employed intensive care unit survivors are jobless up to 3, 12 and 60 months following hospital discharge. Survivors returning to work often experience job loss, occupation change or worse employment status. Interventions should be designed and evaluated to reduce the burden of this common and important problem for survivors of critical illness.Trial registration numberPROSPERO CRD42018093135.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Return to work after critical illness: a systematic review and meta-analysis

Kamdar

Suri

Suchyta

et al. 2019

Thorax

189

138

View full text Add to dashboard Cite

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“…Although this syndrome has only recently been defined, this phenomenon has been in existence for many years and is not limited to sepsis patients. Rather, PICS is thought to result from a wide array of pathological processes, including severe traumatic injury, extensive burns, and acute pancreatitis ( 1 , 8 , 188 , 189 ).…”

Section: Pics Is the Final Common Denominator Of Failed Resolution Ofmentioning

confidence: 99%

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy

et al. 2018

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Clinical and technological advances promoting early hemorrhage control and physiologic resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly decreased in-hospital mortality for many critically ill patient populations. However, a substantial proportion of severe trauma and sepsis survivors will develop protracted organ dysfunction termed chronic critical illness (CCI), defined as ≥14 days requiring intensive care unit (ICU) resources with ongoing organ dysfunction. A subset of CCI patients will develop the persistent inflammation, immunosuppression, and catabolism syndrome (PICS), and these individuals are predisposed to a poor quality of life and indolent death. We propose that CCI and PICS after trauma or sepsis are the result of an inappropriate bone marrow response characterized by the generation of dysfunctional myeloid populations at the expense of lympho- and erythropoiesis. This review describes similarities among CCI/PICS phenotypes in sepsis, cancer, and aging and reviews the role of aberrant myelopoiesis in the pathophysiology of CCI and PICS. In addition, we characterize pathogen recognition, the interface between innate and adaptive immune systems, and therapeutic approaches including immune modulators, gut microbiota support, and nutritional and exercise therapy. Finally, we discuss the future of diagnostic and prognostic approaches guided by machine and deep-learning models trained and validated on big data to identify patients for whom these approaches will yield the greatest benefits. A deeper understanding of the pathophysiology of CCI and PICS and continued investigation into novel therapies harbor the potential to improve the current dismal long-term outcomes for critically ill post-injury and post-infection patients.

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Post‐intensive care syndrome: Recent advances and future directions

Inoue,

Nakanishi,

Amaya

et al. 2024

Acute Medicine & Surgery

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Post‐intensive care syndrome comprises physical, cognitive, and mental impairments in patients treated in an intensive care unit (ICU). It occurs either during the ICU stay or following ICU discharge and is related to the patients' long‐term prognosis. The same concept also applies to pediatric patients, and it can greatly affect the mental status of family members. In the 10 years since post‐intensive care syndrome was first proposed, research has greatly expanded. Here, we summarize the recent evidence on post‐intensive care syndrome regarding its pathophysiology, epidemiology, assessment, risk factors, prevention, and treatments. We highlight new topics, future directions, and strategies to overcome post‐intensive care syndrome among people treated in an ICU. Clinical and basic research are still needed to elucidate the mechanistic insights and to discover therapeutic targets and new interventions for post‐intensive care syndrome.

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The long-term quality of life in patients with persistent inflammation-immunosuppression and catabolism syndrome after severe acute pancreatitis: A retrospective cohort study

Cited by 21 publications

References 28 publications

Return to work after critical illness: a systematic review and meta-analysis

Return to work after critical illness: a systematic review and meta-analysis

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy

Post‐intensive care syndrome: Recent advances and future directions

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