The long-term mortality of spontaneous bacterial peritonitis in cirrhotic patients: A 3-year nationwide cohort study

Abstract

Background/Aims: There is no nationwide population-based study for the long-term mortality after single episode of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. Our study showed the short-term and long-term mortalities, and identified the mortality risk of SBP. Materials and Methods: The National Health Insurance Database, derived from the Taiwan National Health Insurance program, was used to collect data from 16,992 cirrhotic patients. These cirrhotic patients were classified into three groups: SBP group (n=451, 2.7%), ascites without SBP group (n=2,564, 15.1%), and non-ascites (n=13,977, 82.3%) group. Each patient was followed up to 3 years after the initial hospitalization. Results: The 30-day mortalities in SBP, ascites without SBP, and non-ascites groups were 24.2%, 14.1%, and 8.1%, respectively. The 3-year mortalities in SBP, ascites without SBP, and non-ascites groups were 66.5%, 61.1%, and 41.5%. After Cox's regression analysis adjusted by the patients' age, gender, and underlying medical disorders, the SBP patients (hazard ratio=2.52) and ascites without SBP patients (hazard ratio=1.91) have higher risk for 3-year mortality than those without ascites. Conclusion: Cirrhotic patients with SBP have a 2.5-fold increase of 3-year mortality, compared to those without ascites.

To Study the Incidence, Predictive Factors and Clinical Outcome of Spontaneous Bacterial Peritonitis in Patients of Cirrhosis with Ascites

“…Tsung et al, found 30-day mortality in SBP patients of 24.2% and three year mortality of 66.5%.They saw a higher mortality in patients of ascites with SBP, than those without ascites. They found that Cirrhotic patients with SBP have 2.5 fold increase of 3-year mortality, compared to those without ascites [18].…”

Predictors of Short-Term Mortality Following First Episode of Spontaneous Bacterial Peritonitis in Hospitalized Cirrhotic Patients

“…The 30-day in-hospital mortality of SBP is variable but has been reported to be anywhere between 18% [ 17 ] and up to 31.9% [ 16 ]. Long-term three-year mortality of SBP has been estimated to be around 66.5% in one study [ 18 ], with a 2.5-fold increase in mortality compared to those without ascites. In our study, the unadjusted 30-day in-hospital mortality was 19.7%, which is in the lower spectrum of that reported from recent systematic reviews.…”

Mortality from Spontaneous Bacterial Peritonitis Among Hospitalized Patients in the USA

“…The Spanish study was similar to ours in included time period, analytical methodology, and reported mortality. Another study from Taiwan, using the National Health Insurance Database, examined the nationwide mortality of cirrhotic patients with SBP in 2004 (42). The authors found a 30-day mortality of 24.2%.…”