The long-term infective complications in patients after kidney transplantation and  photopheresis

Faenko, A. P.; Зулькарнаев, А. Б.; Fedilina, V A; Kantaria, Rusudana; Kildyushevskyi, A V; Vatazin, Andrey

doi:10.18565/urology.2018.5.28-34

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“…This immunogenic effect for controlling infections in KT patients should be explored, since limited data are still available. In this sense, to our knowledge only there are two Russian studies reporting their clinical experience in KT, demonstrating a declining infectious complication rates in patients who underwent KT with prophylactic use of ECP 38,39 . In a study of Barr et al in cardiac transplantation, the addition of ECP not only was associated with a decrease of the risk of rejection without increasing the incidence of infection, but also CMV‐DNA was detected significantly less frequently in the photopheresis group than in the standard‐therapy group 24 …”

Section: Discussionmentioning

confidence: 97%

Immunogenic and immunotolerogenic effects of extracorporeal photopheresis in high immunological risk kidney recipients. A single center case series

Xipell

Molina‐Andújar

Cid

et al. 2021

J of Clinical Apheresis

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The immunomodulatory effects of extracorporeal photopheresis (ECP) have been used for the treatment of T‐cell mediated disorders, such as rejection in organ transplantation. Currently, it is an established therapy for heart and lung rejection, but not for kidney transplantation (KT), where experience is limited. In addition, some data suggest that ECP could generate an immune response against infections, thus being an alternative for the treatment of rejection in case of active or high‐risk of infection. In the present study, we analyze four cases of use of ECP as concomitant therapy in patients with KT and high risk of opportunistic infections due to the high burden of immunosuppression throughout their renal diseases. Two patients had concomitant viral infection (cytomegalovirus and BK virus, respectively) and three patients were on treatment for graft rejection. In the two patients with active viral infection, the infection was successfully controlled during ECP treatment. In all cases, ECP has been shown to be a safe procedure, without complications.

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Section: Discussionmentioning

confidence: 97%