The long-term in vivo behavior of polymethyl methacrylate bone cement in total hip arthroplasty

Akiyama, Haruhiko; Takemoto, Mitsuru; Kawai, Toshiyuki; Yamamoto, Kōji; Yamamuro, Takao; Oonishi, Hironobu; Nakamura, Takashi

doi:10.3109/17453674.2011.625538

Cited by 16 publications

(16 citation statements)

References 22 publications

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“…In addition, surface preparation methods for adhesive bonding in engineering applications almost exclusively aim to increase the surface roughness, which ultimately leads to the development of stronger and more durable adhesive bonds [39]. The water inside the cement material could act as a plasticiser, causing structural changes and degradation of the polymer structure, as described by other authors [40,41]. Although cement initially ensures the mechanical stability of implants, in prolonged use, it is reported to reduce in strength.…”

Section: Resultsmentioning

confidence: 99%

Seasoning Polymethyl Methacrylate (PMMA) Bone Cements with Incorrect Mix Ratio

2019

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Cemented joint prostheses are widely used in orthopaedic surgery; however, implants/bone bonds are known to be susceptible to aseptic loosening, particularly in the case of long-term performance. The exact mechanism of this failure is under constant examination. One of the critical factors to the final mechanical functionality of bone cement can be an incorrect mix ratio of a two-component material (powdered polymer and liquid monomer). It can result in the deterioration of the final mechanical strength properties. The paper presents the results from an experimental study on the effects of the deviation from the correct mix ratio on the moisture uptake and the compression strength of cement depending on the seasoning time in Ringer’s solution. The results were subjected to statistical analysis and a mathematical model was developed.

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Section: Resultsmentioning

confidence: 99%

Seasoning Polymethyl Methacrylate (PMMA) Bone Cements with Incorrect Mix Ratio

2019

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“…[25][26][27][28] PMMA is known to be a fully biocompatible polymer and has already had a long history in medical applications. 29 Dyeloaded NPs based on this polymer have shown excellent bioimaging properties providing excellent brightness 25,30 of the loaded fluorophore, enabling single-particle imaging inside living cells 27,31 and even detection of single molecule events at very low illumination light intensities. 32,33 Importantly, PMMA-based NPs can be loaded by various active compounds and contrast agents (including drugs).…”

Section: Meaningful Monitoring Of the Behavior Of Single Nps In Vivo mentioning

confidence: 99%

Ultrabright Fluorescent Polymeric Nanoparticles with a Stealth Pluronic Shell for Live Tracking in the Mouse Brain

Khalin¹,

Heimburger

Melnychuk

et al. 2020

ACS Nano

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The inability to visualize single organic nanoparticles (NPs) in vivo is an unsolved issue in the field of nanomedicine. To enable high single particle fluorescence, we loaded polymer poly(methyl methacrylate)-sulfonate (PMMA-SO3H) NPs with octadecyl rhodamine B together with hydrophobic counter-ions as a fluorophore insulator to prevent aggregation-induced quenching. To create NPs with stealth properties we used the amphiphilic block copolymers pluronic F-127 and F-68. Fluorescence correlation spectroscopy (FCS) and Förster resonance energy transfer (FRET) showed that pluronics remain at the NP surface after dialysis (density: one amphiphile per 5.5 nm 2) and protected NPs from degradation by serum proteins and surfactants. Single particle brightness was increased 150-fold as compared to commercially available preparations by increasing dye loading to 20 wt% and optimizing particle size. Added to primary cultured neurons, these NPs were stable and interacted with dendrites and axons. After intravenous injection in mice, NPs could be tracked in cerebral vessels for at least 1h by in vivo two-photon microscopy. Following brain injury or neuroinflammation, NPs extravasated from meningeal vessels, were taken up by meningeal macrophages, and entered the brain parenchyma. In summary, we developed biocompatible NPs suitable for drug delivery with in vitro and in vivo stealth properties and extremely bright fluorescence. Thus, individual NPs could be tracked in mouse brain and their dynamics visualized with subcellular resolution. Using superbright NPs may thus open new avenues for the investigation of NPs in living organisms.

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“…Oonishi et al [18] reported that the bending strength in CMW1 cement after implantation decreased with increasing time in vivo and depended on the density of the bone cement, which we assume to be determined by the porosity.…”

Section: Discussionmentioning

confidence: 81%

Biodegradation of Polymethylmethacrylate Bone Cement May Not Be a Serious Issue in Total Hip Arthroplasty—Retrieval Study for Knoop Hardness and Young’s Modulus

Maruyama¹,

Capello²

2013

OJO

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Introduction:To investigate a long-term in vivo deterioration of polymethylmethacrylate (PMMA) bone cement over time, we evaluated retrieved PMMA cement in terms of chemical elements presenting in the cement using energy dispersive analysis of X-rays; Knoop hardness; and the Young's modulus using scanning acoustic microscopy. Materials and Methods: For mechanical evaluation, we could neglect the influences of entrapped air bubbles or blood by the use of small specimens. The study was based on thirteen cement samples (six used in the acetabulum and seven in the femur) derived from eight patients (age at revision surgery: mean 72.5, range 68 to 79). All of these samples were Simplex-P  cement. They were functioning well at least ten years after the previous surgery. Duration until revision surgery was ranged 12 to 25 years (average, 17.4 years). The reason for revision was aseptic mechanical loosening. Twenty samples of Simplex-P  cement were served by manually mixing as a control. Results: The average of the hardness of the cement was 17.0 ± 1.2 (range, 13.4 -20.6). In the control, the hardness was 17.8 ± 1.5 (range, 14.0 -24.6). There was no significant difference between these values. The mean of Young's modulus of the cement was 5.61 ± 0.19 GPa (range, 5.09 -6.10). In the control, the modulus was 6.04 ± 0.13 GPa (range,). Although the modulus was significantly less than that of the control, there was only 7% decrease in average between twelve and twenty-five years in vivo. Conclusions: Our results suggest that long-term implantation and functional loading in vivo may not be the limiting factor in the mechanical integrity of the bone cement.

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The long-term in vivo behavior of polymethyl methacrylate bone cement in total hip arthroplasty

Cited by 16 publications

References 22 publications

Seasoning Polymethyl Methacrylate (PMMA) Bone Cements with Incorrect Mix Ratio

Seasoning Polymethyl Methacrylate (PMMA) Bone Cements with Incorrect Mix Ratio

Ultrabright Fluorescent Polymeric Nanoparticles with a Stealth Pluronic Shell for Live Tracking in the Mouse Brain

Biodegradation of Polymethylmethacrylate Bone Cement May Not Be a Serious Issue in Total Hip Arthroplasty—Retrieval Study for Knoop Hardness and Young’s Modulus

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