The long-term impacts of preterm birth and associated morbidities on bone health in preschool children: a prospective cross-sectional study from Turkey

Baş, Evrim Kıray; Bülbül, Ali; Şirzai, Hülya; Arslan, Selda; Uslu, Sinan; Baş, Vedat; Zübarioğlu, Adil Umut; Çelik, Muhittin; Dursun, Mesut; Güran, Ömer; Kuran, Banu

doi:10.1080/14767058.2020.1730801

Cited by 4 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The influence of gestational age was investigated in seven studies, presented in Table S2 . In the study conducted by Bas et al [ 77 ], children born preterm had lower BMD in comparison to those born at term. In two other studies, no association was found [ 10 , 24 ].…”

Section: Findings and Discussionmentioning

confidence: 99%

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

2021

View full text Add to dashboard Cite

There is growing evidence that bone health may be programmed in the first years of life. Factors during the prenatal period, especially maternal nutrition, may have an influence on offspring’s skeletal development and thus the risk of osteoporosis in further life, which is an increasing societal, health and economic burden. However, it is still inconclusive which early life factors are the most important and to what extent they may affect bone health. We searched through three databases (PubMed, Google Scholar, Cochrane Library) and after eligibility criteria were met, the results of 49 articles were analyzed. This narrative review is an overall summary of up-to-date studies on maternal diet, nutritional status, and birth-related factors that may affect offspring bone development, particularly bone mineral density (BMD). Maternal vitamin D status and diet in pregnancy, anthropometry and birth weight seem to influence BMD, however other factors such as subsequent growth may mediate these associations. Due to the ambiguity of the results in the analyzed studies, future, well-designed studies are needed to address the limitations of the present study.

show abstract

Section: Findings and Discussionmentioning

confidence: 99%

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

2021

View full text Add to dashboard Cite

show abstract

“…3 Preterm children (<37 weeks) have markedly lower bone mineral density (BMD) than their term counterparts when BMD is measured 7 or 8 years later. 4 Therefore, physicians must stress the importance of good bone health during childhood, especially for children born prematurely.…”

Section: Normal Bone Healthmentioning

confidence: 99%

“…Breastfeeding at a young age and having lean body mass have been shown to push children into higher BMD quantiles. 4,13 Furthermore, smoking and hormone levels contribute to fracture incidence.…”

Section: Fracture Risk In Children: Identification Of Modifiable Factorsmentioning

confidence: 99%

A Comprehensive Review of Bone Health in a Child: From Birth to Adulthood

Tabaie,

O'Mara,

Sheppard

et al. 2024

J Am Acad Orthop Surg

View full text Add to dashboard Cite

Bone health is critical for growth and development during childhood. Although fractures are common in children, fractures occurring in the absence of trauma should prompt physicians to consider underlying bone health disorders. This article provides an overview of the current definition of osteoporosis in children, highlighting its limitations and the potential for underdiagnosis. It also discusses the timing of screening initiation and various techniques used to assess bone health, along with their respective benefits and limitations. In addition, this article identifies several causes of primary and secondary osteoporosis in children, shedding light on previously overlooked disorders that can contribute to poor bone quality. The article emphasizes the importance of a multidisciplinary approach to therapeutic management and aims to optimize patient outcomes and improve the overall care of pediatric bone health disorders.

show abstract

Skeletal consequences of preterm birth in pigs as a model for preterm infants

Wilson,

Ko,

Moran

et al. 2024

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Preterm birth affects about 10% of all live births with many resultant health challenges, including metabolic bone disease of prematurity (MBDP) which is characterized by elevated alkaline phosphatase, suppressed phosphate, and deficient skeletal development. Because of the lack of an animal model, very little is known about bone structure, strength, and quality after preterm birth. This study investigated the utility of a pig model to replicate clinical features of preterm birth, including MBDP, and sought to determine if early postnatal administration of insulin-like growth factor (IGF)-1 was an effective treatment. Preterm pigs, born by caesarean section at 90% gestation, were reared in intensive care facilities (respiratory, thermoregulatory and nutritional support) and compared with sow-reared term pigs born vaginally. Preterm pigs were systemically treated with vehicle or IGF-1 (recombinant human IGF-1/BP-3, 2.25 mg/kg/day). Tissues were collected at postnatal days 1, 5, and 19 (the normal weaning period in pigs). Most bone-related outcomes were affected by preterm birth throughout the study period whereas IGF-1 supplementation had almost no effect. By day 19, alkaline phosphatase was elevated, phosphate and calcium were reduced, and the bone resorption marker CTX-1 was elevated in preterm pigs compared to term pigs. Preterm pigs also had decrements in femoral cortical cross-sectional properties, consistent with reduced whole-bone strength. Thus, the preterm pig model replicates many features of preterm bone development in infants, including features of MBDP, and allows for direct interrogation of skeletal tissues, enhancing the field’s ability to examine underlying mechanisms.

show abstract

The long-term impacts of preterm birth and associated morbidities on bone health in preschool children: a prospective cross-sectional study from Turkey

Cited by 4 publications

References 43 publications

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

A Comprehensive Review of Bone Health in a Child: From Birth to Adulthood

Skeletal consequences of preterm birth in pigs as a model for preterm infants

Contact Info

Product

Resources

About