The Long‐Term Effects of Feeding Honey Compared with Sucrose and a Sugar‐Free Diet on Weight Gain, Lipid Profiles, and DEXA Measurements in Rats

Chepulis, Lynne; Starkey, Nicola J.

doi:10.1111/j.1750-3841.2007.00592.x

Cited by 97 publications

(76 citation statements)

References 56 publications

(64 reference statements)

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“…At post-intervention, the smoker group receiving honey supplementation showed no significant difference in the level of TG. This result is supported by animal studies that shows no significant difference in the level of TG when rats are fed either with 10% honey or sucrose-based diet for 6 weeks [24] or 52 weeks [14]. On the other hand, consumption of honey for 8 weeks among diabetic patients [25] and 4 weeks among obese subjects [26] significantly reduces the level of TG.…”

Section: Discussionsupporting

confidence: 73%

“…Furthermore, rodent fed with honey for 6 weeks shows no significant difference in the level of HDL. However, several studies shows increased levels of HDL after supplementation of honey [14,25]. Consumption of honey for 8 weeks among diabetic type 2 patients [25] and 4 weeks among obese subjects [26] significantly reduces the level of HDL.…”

Section: Discussionmentioning

confidence: 99%

“…In animal study, previous study has found that rats have lower TG concentrations following 2 weeks of purified diets containing 65% carbohydrate from honey compared with a fructose/ glucose mixture [13]. Meanwhile, the HDL level is significantly increased in adult Sprague Dawley rats fed with 10% powdered honey ad libitum with 21% water for 52 weeks [14]. In human study, supplementation of 70 g of honey for 30 days among overweight and obese individuals significantly reduces TC, LDL and TG as well as increases HDL levels [15].…”

Section: Introductionmentioning

confidence: 99%

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An Open-Label Pilot Study to Assess Honey Supplementation in Improving Lipid Profiles Among Chronic Smokers

Mohamed¹

2015

J Integr Med Ther

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Objectives: The objective of this study was to determine the effects of 12-week honey oral supplementation on fasting serum lipid profiles among chronic smokers. Design Subjects:Participants from non smokers (n=32) and chronic smokers (n=64) aged between 20 -50 years old were recruited. Participants from smoker group should have smoked at least 10 cigarettes per day for more than 5 years. Interventions:The chronic smokers were further randomized into 2 groups namely smoker without honey (n=32) and smoker with honey (20 g/day) for 12 weeks (n=32).Outcome measures: Outcome measures were triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol (TC) levels between non smokers and chronic smokers at pre-intervention as well as the differences of these parameters between pre and post-intervention among smoker without honey and smoker with honey groups.Results: At pre-intervention, chronic smokers had significantly lower HDL and higher TG, LDL and TC levels than non smokers. In smoker with honey group, TC and LDL levels were significantly reduced at postintervention than at pre-intervention. No significant changes were found in smoker without honey group. Conclusion:This study may suggest that honey supplementation improves lipid profiles in chronic smokers which in turn may reduce the subsequent risk of cardiovascular diseases.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Open-Label Pilot Study to Assess Honey Supplementation in Improving Lipid Profiles Among Chronic Smokers

Mohamed¹

2015

J Integr Med Ther

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“…Chepulis and Starkey (23) found that although there was an increase in HDLcholesterol in honey-fed rats compared with rats fed sucrose or a sugar free diet, but there were no other differences in lipid profiles. Nemoseck et al, (13) Alagwu et al (17) and Majid et al (20) also suggest that the supplementation of honey will increase the excretion of cholesterol through bile acids thereby lowering blood cholesterol levels.…”

Section: Discussionmentioning

confidence: 99%

Honey improves lipid profile of diet-induced hypercholesterolemic rats

Nurmasitoh

Pramaningtyas

2016

UnivMed

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BACKGROUNDCoronary heart disease (CHD) is a major cause of morbidity and mortality throughout the world, including Indonesia. One of the risk factors for CHD is hypercholesterolemia. One of the natural products that has been developed for the treatment of hypercholesterolemia is honey. Honey contains fructooligosaccharides, various vitamins, minerals, and enzymes which are supposedly able to lower blood cholesterol levels. This research aimed to study the influence of honey on the levels of blood total cholesterol, triglyceride, and low density lipoprotein (LDL) levels in Wistar rats. METHODSThis study was of experimental post test control group design. Twentyfour male Wistar rats (Rattus norvegicus) were randomly divided into 4 groups. K1 was the negative control group (with normal diet), K2 was the positive control group (with high-fat diet), P1 was fed a high-fat diet for 7 days, followed by high-fat diet plus honey for the next 7 days. P2 was fed a high-fat diet for 7 days, followed by regular diet plus honey for the next 7 days. After completion of this treatment, total cholesterol, triglycerides, and LDL levels were measured by the cholesterol oxidase phenol+aminophenazone (CHOD-PAP) method using enzymatic spectrophotometry principles. RESULTSThere were significant differences in total cholesterol, triglyceride, and LDL levels between all groups after day 15 (p<0.05). CONCLUSIONHoney supplementation was able to reduce the blood levels of total cholesterol, triglycerides, and LDL. Honey supplementation accompanied by non-cholesterol feeds could more effectively lower total cholesterol, triglycerides, and LDL serum levels in Wistar rats. Keywords

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“…Honey has many reported physiological effects and is well adapted to growth in animal models [1][2][3] . It contains more than 300 bioactive substances which include fructose, glucose, proteins, phytochemicals, oligosaccharides, minerals, vitamins and other micronutrients [4] .…”

Section: Introductionmentioning

confidence: 99%

Growth and Metabolic Response of Suckling Rats Fed with Natural Honey Supplements

Ajibola¹,

Olusakin²,

Oyewale³

et al. 2016

IJFNS

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The growth and metabolic response of unweaned rats fed with honey were investigated. Ten day old Sprague-Dawley rats were gavaged with 50% honey solution (low dose 10 ml/kg or high dose 20 ml/kg) twice daily for ten days. All data were expressed as mean ± SEM and analyzed by one way ANOVA. Pups nourished with honey had 5.41-7.43% body weight gain than untreated rats. Tibial length was significantly increased (p < 0.05) in the honey-fed group than control (6-9%). The differences in growth could be attributed to circulating insulin-like growth factor-1 as the concentrations were also significantly higher in the honey-fed pups. There were no differences in the circulating and stored metabolic substrates (glucose, triglycerides, free fatty acid, cholesterol, lipid and glycogen) between the treatment and control groups. The plasma alanine transaminase was not affected by the treatments, however there was significantly increased plasma alkaline phosphatase activity in the male pups compared with female litter mates. Short term (10-day) oral administration of honey resulted in growth promotion and increased alkaline phosphatase in male rats, possibly in relation to bone growth and caused no liver pathology in neonatal rats. It was concluded that honey supplements administered orally to suckling rats have a positive effect on body weight and linear growth, and these effects are beneficial during weaning and development of fast growing animals.

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The Long‐Term Effects of Feeding Honey Compared with Sucrose and a Sugar‐Free Diet on Weight Gain, Lipid Profiles, and DEXA Measurements in Rats

Cited by 97 publications

References 56 publications

An Open-Label Pilot Study to Assess Honey Supplementation in Improving Lipid Profiles Among Chronic Smokers

An Open-Label Pilot Study to Assess Honey Supplementation in Improving Lipid Profiles Among Chronic Smokers

Honey improves lipid profile of diet-induced hypercholesterolemic rats

Growth and Metabolic Response of Suckling Rats Fed with Natural Honey Supplements

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