The long-term effects of acute exposure to ionising radiation on survival and fertility in Daphnia magna

Sarapultseva, Elena I.; Dubrova, Yuri E.

doi:10.1016/j.envres.2016.05.046

Cited by 25 publications

(7 citation statements)

References 35 publications

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“…magna after exposure is Gy and 1500 Gy for 24 and 48 hrs, respectively (Fuma et al, 2003). On the other hand, Sarapultseva and Dubrova (2016) observed a significant shortening in the life span of D. magna after acute exposure to 60 Co (total doses of 100, 1000 and 10000 mGy), nonetheless, these effects were observed 4 to 7 days following radiation exposure. Even though there were no significant effects in mortality in irradiated daphnia, the gamma radiation dose rates used in this study can be considered high, especially when compared to the suggested ecosystem screening benchmark of 0.24 mGy/h for the protection of freshwater ecosystems from radioactive substances (Garnier-Laplace et al, 2010).…”

Section: Discussionmentioning

confidence: 93%

Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna

Gomes

Shang

Brede

et al. 2018

Science of The Total Environment

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Among aquatic organisms, invertebrate species such as the freshwater crustacean Daphnia magna are believed to be sensitive to gamma radiation, although information on responses at the individual, biochemical and molecular level is scarce. Following gamma radiation exposure, biological effects are attributed to the formation of free radicals, formation of reactive oxygen species (ROS) and subsequently oxidative damage to lipids, proteins and DNA in exposed organisms. Thus, in the present study, effects and modes of action (MoA) have been investigated in D. magna exposed to gamma radiation (dose rates: 0.41, 1.1, 4.3, 10.7, 42.9 and 106 mGy/h) after short-term exposure (24 and 48 h). Several individual, cellular and molecular endpoints were addressed, such as ROS formation, lipid peroxidation, DNA damage and global transcriptional changes. The results showed that oxidative stress is one of the main toxic effects in gamma radiation exposed D. magna, mediated by the dose-dependent increase in ROS formation and consequently oxidative damage to lipids and DNA over time. Global transcriptional analysis verified oxidative stress as one of the main MoA of gamma radiation at high dose rates, and identified a number of additional MoAs that may be of toxicological relevance. The present study confirmed that acute exposure to gamma radiation caused a range of cellular and molecular effects in D. magna exposed to intermediate dose rates, and highlights the need for assessing effects at longer and more environmentally relevant exposure durations in future studies.

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Section: Discussionmentioning

confidence: 93%

Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna

Gomes

Shang

Brede

et al. 2018

Science of The Total Environment

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“…34 Some invertebrate species have also been shown to be extremely resistant to radiation, while others such as Daphnia Magna have shown severe negative impacts at doses as low as 100 and 1000 mGy. 8,9 Generally, it has been noted that adult LD50 values for insect can range from 20-3000 Gy with subadult stages showing impacts at doses as low as 1-2 Gy for certain species. 35,36 The literature therefore indicates the diversity in reproductive and life history responses as it pertains to different invertebrate species and that its likely that one model or dose-response relationship will not coincide to all species.…”

Section: Discussionmentioning

confidence: 99%

“…4 At an organism level, excess ROS's can cause a plethora of detrimental impacts including cancer, increased dominant lethal mutations, reduced survival, fertility and death. [5][6][7][8][9] However, at low doses, ionizing radiation has been shown to elicit beneficial (hormetic) effects. This biphasic model of radiation exposure is characterized by low-dose benefits and high-dose harm.…”

Section: Introductionmentioning

confidence: 99%

Trans-Generational Impacts of Paternal Irradiation in a Cricket: Damage, Life-History Features and Hormesis in F1 Offspring

Fuciarelli

Rollo

2020

Dose-Response

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Animals exposed to significant stress express multi-modal responses to buffer negative impacts. Trans-generational impacts have been mainly studied in maternal lines, with paternal lines having received less attention. Here, we assessed paternal generational effects using irradiated male crickets ( Acheta domesticus), and their F1 offspring (irradiated males mated to unirradiated females). Paternal transmission of radiation impacts emerged in multiple life history traits when compared to controls. Irradiated males and their F1 offspring expressed hormetic responses in survivorship and median longevity at mid-range doses. For F0 males, 7 Gy & 10 Gy doses extended F0 longevity by 39% and 34.2% respectively. F1 offspring of 7 Gy and 10 Gy sires had median lifespans 71.3% and 110.9% longer, respectively. Survivorship for both F0 7 Gy (p < 0.0001) and 10 Gy (p = 0.0055) males and F1 7 Gy and 10 Gy (p < 0.0001) offspring significantly surpassed that of controls. Irradiated F0 males and F1 offspring had significantly reduced growth rates. For F0 males, significant reductions were evident in 4Gy-12 Gy males and F1 offspring in 4 Gy (p < 0.0001), 7 Gy (p < 0.0001), and 10 Gy (p = 0.017). Our results indicate paternal effects; that irradiation directly impacted males but also mediated diverse alterations in the life history features (particularly longevity and survivorship) of F1 offspring.

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“…Given the fact that dysfunction of certain repair genes can lead to the inheritance of genetic effects by the offspring of irradiated parents (Yushkova, 2020), it would be interesting to consider how the interaction of the repair genes and transpositional activity of TEs affect the transgenerational transmission of radiation-induced genome instability. Moreover, the aforementioned studies on the transgenerational effects of irradiation have been mainly carried out on animals using high doses of irradiation (Wiley et al, 1997;Barber et al, 2002;Sarapultseva and Malina, 2009;Sarapultseva and Bychkovskaya, 2010;Sarapultseva and Gorski, 2013;Gomes et al, 2015;Sarapultseva and Dubrova, 2016;Lecomte-Pradines et al, 2017;Fuller et al, 2019;Hancock et al, 2019). Therefore, from this point of view, it is also important to consider whether parental radiation exposure affect cytogenetic and epigenetic traits inherited by the offspring of irradiated parents.…”

Section: Introductionmentioning

confidence: 99%

Involvement of DNA Repair Genes and System of Radiation-Induced Activation of Transposons in Formation of Transgenerational Effects

Yushkova

2020

Front. Genet.

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The study of the genetic basis of the manifestation of radiation-induced effects and their transgenerational inheritance makes it possible to identify the mechanisms of adaptation and possible effective strategies for the survival of organisms in response to chronic radioactive stress. One persistent hypothesis is that the activation of certain genes involved in cellular defense is a specific response of the cell to irradiation. There is also data indicating the important role of transposable elements in the formation of radiosensitivity/radioresistance of biological systems. In this work, we studied the interaction of the systems of hobo transposon activity and DNA repair in the cell under conditions of chronic low-dose irradiation and its participation in the inheritance of radiation-induced transgenerational instability in Drosophila. Our results showed a significant increase of sterility and locus-specific mutability, a decrease of survival, fertility and genome stability (an increase the frequency of dominant lethal mutations and DNA damage) in non-irradiated F1/F2 offspring of irradiated parents with dysfunction of the mus304 gene which is responsible for excision and post-replicative recombination repair and repair of double-stranded DNA breaks. The combined action of dysfunction of the mus309 gene and transpositional activity of hobo elements also led to the transgenerational effects of irradiation but only in the F1 offspring. Dysfunction of the genes of other DNA repair systems (mus101 and mus210) showed no visible effects inherited from irradiated parents subjected to hobo transpositions. The mei-41 gene showed specificity in this type of interaction, which consists in its higher efficiency in sensing events induced by transpositional activity rather than irradiation.

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The long-term effects of acute exposure to ionising radiation on survival and fertility in Daphnia magna

Cited by 25 publications

References 35 publications

Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna

Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna

Trans-Generational Impacts of Paternal Irradiation in a Cricket: Damage, Life-History Features and Hormesis in F1 Offspring

Involvement of DNA Repair Genes and System of Radiation-Induced Activation of Transposons in Formation of Transgenerational Effects

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