The long-term effect of oral isotretinoin therapy on macula ganglion cell complex thickness

Demirok, Gülizar; Topalak, Yasemin; Gündüz, Özge; Yıldırım, Dilsun; Kocamaz, Mehmet Fatih; Şengün, Ahmet

doi:10.1080/15569527.2016.1265549

Cited by 10 publications

(7 citation statements)

References 16 publications

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“…We were unable to find any statistically significant difference in the GCL thickness in our study as well. Demirok et al [16] found no significant effect on macular ganglion cell layer thickness in patients who used systemic isotretinoin for 1 year.…”

Section: Discussionmentioning

confidence: 99%

Macular Ganglion Cell Layer Thickness In Patients Using Oral Isotretinoin

Kocamış

Acer

2017

JOS

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Objective: Determining the effects on macular ganglion cell layer thickness in patients using isotretinoin by utilization of optical coherence tomography. Material and Methods:Sixty eyes of 30 patients using isotretinoin and 60 eyes of 30 control group patients in the same age range were included in this study. The average age of the patients using isotretinoin was; 21.2 ± 3.62 years, whereas the average age of the patients in the control group was 22.7 ± 3.7 years. The thickness of the macular ganglion cell layer (GCL), the retinal nerve fiber layer (RNFL) and subfoveal macular thickness of all patients were measured with optical coherence tomography (OCT). Results:The macular ganglion cell layer thickness in the OCT of the patients using isotretinoin was measured as 61.6±4.6 µm, 62.4±4.4µm, for the right and left eye respectively, whereas the thickness in the control group was measured as 60.6±4.1µm, 61.2±4.9µm respectively. The retinal nerve fiber layer thickness in the OCT of the patients using isotretinoin was measured as 74.8±11.3µm, 76.2±12.3µm, for the right and left eye respectively, whereas the thickness in the control group was measured as 72.2±10.5µm, 74.1±1.9µm, respectively. Conclusions:No statistically significant difference was observed in the macular ganglion cell layer thickness, retinal nerve fiber layer thickness and macular thickness in terms of both the right and left eyes between the control group and patients using isotretinoin.

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Section: Discussionmentioning

confidence: 99%

Macular Ganglion Cell Layer Thickness In Patients Using Oral Isotretinoin

Kocamış

Acer

2017

JOS

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“…Besides from damage to the OS, retinal toxicity, neuroophthalmological disorders, decreased dark adaptation and color vision, and cataract formation have also been linked to isotretinoin use, however, information is scant. 5,24 Studies evaluating the nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness of the retina and macula, respectively, have yielded unrewarding results.…”

Section: Other Ocular Adverse Effectsmentioning

confidence: 99%

“…29 Nevertheless, other studies evaluating the RNFL and GCC thickness after systemic isotretinoin use for 6 and 12 months, respectively, found no significant differences. 5,30 Other retina-related complications including vascular occlusions, 31 premacular hemorrhage, 32 serous retinal detachment, 33 and vitreous disturbance have been reported. 24 However, none of the side effects mentioned above fulfills the WHO criteria mentioned above to be considered as "certain."…”

Section: Other Ocular Adverse Effectsmentioning

confidence: 99%

“…Regarding the latter, ocular surface (OS) alterations including dry eye disease (DED), blepharitis, Meibomian gland dysfunction (MGD), and conjunctivitis comprise the most frequent ocular side effects 4 . Other uncommon side effects as visual field defects, cortical blindness, ocular myasthenia gravis, optic neuritis, and retinal toxicity have been reported 5 . Failure to recognize these ophthalmologic adverse events may lead to significant ocular morbidity.…”

Section: Introductionmentioning

confidence: 99%

“…ous (as in serous retinal detachment or vascular alterations) or environmental-related (dark setting in decreased dark adaptation, brightness in a posterior subcapsular cataract), visual field alterations, and altered color perception are possible effects of isotretinoin use 5,24,33. They could be reported as self-perceived visual alterations or environment-related trouble (stumbling, hitting or falling with peripheral objects).…”

mentioning

confidence: 99%

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Isotretinoin and the eye: A review for the dermatologist

Ruiz-Lozano

Hernández-Camarena

Garza-Garza

et al. 2020

Dermatologic Therapy

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Due to the prevalence of acne vulgaris, isotretinoin is one of the most prescribed drugs among physicians and dermatologists. Although exhibiting an adequate safety profile, adverse events secondary to isotretinoin use are common. Before prescribing isotretinoin, physicians usually inquire about pregnancy and perform serologic tests including cholesterol, triglycerides, and liver enzymes. Ocular manifestations are commonly neglected. Despite being generally mild, ocular manifestations related to either topical or systemic isotretinoin may cause important ocular morbidity. The ocular surface is the most affected site within the eye; however, retinal and optic nerve disease also have been documented. Evaporative dry eye disease, which may range from mild to severe, is the most common adverse ocular effect associated with isotretinoin use. The aim of this review is to present an up-to-date overview for the dermatologist about the prevention, diagnosis, and treatment of the ocular side effects of isotretinoin, and when to refer to the eye specialist.

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