The long-term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina

Saynor, R.; Vérel, D.; Gillott, T.

doi:10.1016/0021-9150(84)90003-0

Cited by 228 publications

(46 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The anti-thrombotic action of fish oils in both healthy human subjects and people at high cardiovascular risk have been extensively investigated during the ensuing decades. Several intervention studies later confirmed the effect on bleeding time in healthy, hyperlipidaemic and patients with heart disease at generally relatively high doses of fish oils (158,159) , while lower doses (<2 g/d) seem to have no significant effect (160,161) . A recent meta-analysis including twenty-four trials in type 2 diabetics (1533 subjects) concluded that fish oils reduced platelet aggregation to ADP and to collagen by 22 and 21%, respectively (162) .…”

Section: Effects Of Epa and Dha On Thrombosis And Haemostasismentioning

confidence: 97%

The differential effects of EPA and DHA on cardiovascular risk factors

2011

View full text Add to dashboard Cite

Compelling evidence exists for the cardioprotective benefits resulting from consumption of fatty acids from fish oils, EPA (20 :5n-3) and DHA (22 :6n-3). EPA and DHA alter membrane fluidity, interact with transcription factors such as PPAR and sterol regulatory element binding protein, and are substrates for enzymes including cyclooxygenase, lipoxygenase and cytochrome P450. As a result, fish oils may improve cardiovascular health by altering lipid metabolism, inducing haemodynamic changes, decreasing arrhythmias, modulating platelet function, improving endothelial function and inhibiting inflammatory pathways. The independent effects of EPA and DHA are poorly understood. While both EPA and DHA decrease TAG levels, only DHA appears to increase HDL and LDL particle size. Evidence to date suggests that DHA is more efficient in decreasing blood pressure, heart rate and platelet aggregation compared to EPA. Fish oil consumption appears to improve arterial compliance and endothelial function; it is not yet clear as to whether differences exist between EPA and DHA in their vascular effects. In contrast, the beneficial effect of fish oils on inflammation and insulin sensitivity observed in vitro and in animal studies has not been confirmed in human subjects. Further investigation to clarify the relative effects of consuming EPA and DHA at a range of doses would enable elaboration of current understanding regarding cardioprotective effects of consuming oily fish and algal sources of long chain n-3 PUFA, and provide clearer evidence for the clinical therapeutic potential of consuming either EPA or DHA-rich oils.

show abstract

Section: Effects Of Epa and Dha On Thrombosis And Haemostasismentioning

confidence: 97%

The differential effects of EPA and DHA on cardiovascular risk factors

2011

View full text Add to dashboard Cite

show abstract

“…The active component of fish oil appears to be the long-chain w-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid), which are known to affect both platelet function and plasma lipid levels (3)(4)(5). Dietary fish oil markedly reduces plasma triglyceride levels in normal and hyperlipidemic subjects and is much more active than equal amounts of polyunsaturated vegetable oil in this regard (6)(7)(8)(9)(10). Dietary fish oil has also been shown to lower plasma cholesterol levels in normal and hyperlipidemic subjects and, in several reports, was as effective, if not more effective, than equal amounts of polyunsaturated vegetable oil (6,7,(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the reduction in plasma cholesterol levels seen with fish oil feeding is due primarily to a decrease in cholesterol carried in the very low and low density lipoprotein (VLDL and LDL) fractions. High density lipoprotein (HDL) cholesterol, in contrast, usually re-mains unchanged or actually increases (5,6,10,15). Although dietary fish oil usually lowers plasma total and LDL-cholesterol levels, the magnitude of this response varies widely from study to study.…”

Section: Introductionmentioning

confidence: 99%

Dietary fish oil stimulates hepatic low density lipoprotein transport in the rat.

Ventura¹,

Woollett²,

Spady³

1989

J. Clin. Invest.

View full text Add to dashboard Cite

These studies were undertaken to examine the effect of fish oil, safflower oil, and hydrogenated coconut oil on the major processes that determine the concentration of low density lipoprotein (LDL) in plasma, i.e., the rate of LDL production and the rates of receptor-dependent and receptor-independent LDL uptake in the various organs of the body. When fed at the 20% level, fish oil reduced plasma LDL-cholesterol levels by 38% primarily by increasing LDL receptor activity in the liver. Dietary safflower oil also increased hepatic LDL receptor activity; however, since the rate of LDL production also increased, plasma LDL-cholesterol levels remained essentially unchanged. Hydrogenated coconut oil had no effect on LDL receptor activity but increased the rate of LDL-cholesterol production causing plasma LDL-cholesterol levels to increase 46%. Dietary fish oil had no effect on the receptor-dependent transport of asialofetuin by the liver, suggesting that the effect of fish oil on hepatic LDL receptor activity was specific and not due to a generalized alteration in the physical properties of hepatic membranes. Finally, dietary fish oil increased hepatic cholesteryl ester levels and suppressed hepatic cholesterol synthesis rates, suggesting that the up-regulation of hepatic LDL receptor activity in these animals was not simply a response to diminished cholesterol availability in the liver.

show abstract

“…Moreover, studies to-date have focused solely on cardiovascular exercise, but it would be interesting to investigate whether n-3 may confer beneficial effects when combined with resistance training. It should be also noted that a high consumption of n-3 can lead to immunosuppression and prolong bleeding time [44,66]. Thus, attempts should be made to establish optimal n-3 dosages to maximise the risk/reward ratio of supplementation.…”

Section: Discussionmentioning

confidence: 99%

Omega-3 fatty acids and exercise: a review of their combined effects on body composition and physical performance

Tiryaki-Sönmez

Schöenfeld

Vatansever-Ozen

2011

Biomedical Human Kinetics

View full text Add to dashboard Cite

SummaryOmega-3 (n-3) fatty acids, and the long-chain n-3 derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in particular, have been extensively researched for their nutritive effects. Among their many purported benefits, n-3 acids have been implicated as positive mediators of cardiovascular health and body composition. It has therefore been speculated that supplementation may enhance the beneficial effects of physical activity, potentiating greater reductions in body fat and improvements in exercise performance. This paper has three objectives: first, to assess the theoretical basis for a synergistic ef-fect when n-3 supplementation is combined with exercise; second, to review the literature as to specific findings on the subject and third, to make relevant conclusions and recommendations for future research.

show abstract

The long-term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina

Cited by 228 publications

References 17 publications

The differential effects of EPA and DHA on cardiovascular risk factors

The differential effects of EPA and DHA on cardiovascular risk factors

Dietary fish oil stimulates hepatic low density lipoprotein transport in the rat.

Omega-3 fatty acids and exercise: a review of their combined effects on body composition and physical performance

Contact Info

Product

Resources

About