The Long Pentraxin PTX3 as a Key Component of Humoral Innate Immunity and a Candidate Diagnostic for Inflammatory Diseases

Jaillon, Sébastien; Bonavita, Eduardo; Gentile, Stefania; Rubino, Marcello; Laface, Ilaria; Garlanda, Cecília; Mantovani, Alberto

doi:10.1159/000368778

Cited by 49 publications

(50 citation statements)

References 133 publications

(218 reference statements)

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“…Based on present knowledge, it may serve as a key factor of humoral innate immunity2728293031. New information indicates that it serves as an endogenous adjuvant for B-cells, at least in spleen32.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells

Mayer¹,

Adam

Glashauser³

et al. 2016

Sci Rep

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Changes in the wall of seminiferous tubules in men with impaired spermatogenesis imply sterile inflammation of the testis. We tested the hypothesis that the cells forming the wall of seminiferous tubules, human testicular peritubular cells (HTPCs), orchestrate inflammatory events and that Toll like receptors (TLRs) and danger signals from the extracellular matrix (ECM) of this wall are involved. In cultured HTPCs we detected TLRs, including TLR2. A TLR-2 ligand (PAM) augmented interleukin 6 (IL-6), monocyte chemo-attractant protein-1 (MCP-1) and pentraxin 3 (PTX3) in HTPCs. The ECM-derived proteoglycan biglycan (BGN) is secreted by HTPCs and may be a TLR2-ligand at HTPCs. In support, recombinant human BGN increased PTX3, MCP-1 and IL-6 in HTPCs. Variable endogenous BGN levels in HTPCs derived from different men and differences in BGN levels in the tubular wall in infertile men were observed. In testes of a systemic mouse model for male infertility, testicular sterile inflammation and elevated estradiol (E2) levels, BGN was also elevated. Hence we studied the role of E2 in HTPCs and observed that E2 elevated the levels of BGN. The anti-estrogen ICI 182,780 blocked this action. We conclude that TLR2 and BGN contribute to sterile inflammation and infertility in man.

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Section: Discussionmentioning

confidence: 99%

“…New information indicates that it serves as an endogenous adjuvant for B-cells, at least in spleen32. PTX3 is being discussed as a potential biomarker for infectious diseases, as it is detectable in the circulation2930. This raises the possibility that it may qualify also as a biomarker for male infertility.…”

Section: Discussionmentioning

confidence: 99%

Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells

Mayer¹,

Adam

Glashauser³

et al. 2016

Sci Rep

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“…Serum amyloid P and C-reactive protein belong to the short pentraxin subfamily, whereas PTX3 is a prototypic member of the long pentraxins and is expressed in various cell types including myeloid dendritic cells and phagocytes [158]. PTX3 participates in distinct aspects of the innate immune response, such as pathogen recognition and opsonization, and regulation of complement and inflammation [158].…”

Section: Endogenous Regulators Of Neutrophil Recruitment To the Pementioning

confidence: 99%

Immune and regulatory functions of neutrophils in inflammatory bone loss

Hajishengallis

Moutsopoulos

Hajishengallis

et al. 2016

Seminars in Immunology

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Although historically viewed as merely anti-microbial effectors in acute infection or injury, neutrophils are now appreciated to be functionally versatile with critical roles also in chronic inflammation. Periodontitis, a chronic inflammatory disease that destroys the tooth-supporting gums and bone, is particularly affected by alterations in neutrophil numbers or function, as revealed by observations in monogenic disorders and relevant mouse models. Besides being a significant debilitating disease and health burden in its own right, periodontitis is thus an attractive model to dissect uncharted neutrophil-associated (patho)physiological pathways. Here, we summarize recent evidence that neutrophils can contribute to inflammatory bone loss not only through the typical bystander injury dogma but intriguingly also through their absence from the affected tissue, where they normally perform important immunomodulatory functions. Moreover, we discuss recent advances in the interactions of neutrophils with the vascular endothelium and – upon extravasation – with bacteria, and how the dysregulation of these interactions leads to inflammatory tissue damage. Overall, neutrophils have both protective and destructive roles in periodontitis, as they are involved in both the maintenance of periodontal tissue homeostasis and the induction of inflammatory bone loss. This highlights the importance of developing approaches that promote or sustain a fine balance between homeostatic immunity and inflammatory pathology.

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“…For example, exhaled breath condensate (EBC) can provide information on biomarkers such as pH, nitrite, H 2 O 2 , 8-isoprostane, and a variety of cytokines that are sensitive to acute wood smoke inhalation. 18–24 Pentraxin-3 (PTX3), a plasma biomarker, is produced following inflammatory stimuli, 25,26 likely due to PTX3’s role in immune cell functioning and its ability to recognize danger-associated molecular patterns. Case in point, PTX3 is an emerging biomarker that, when elevated, is sensitive to acute changes in vascular function.…”

Section: Introductionmentioning

confidence: 99%

Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations

Ferguson

Semmens

Dumke

et al. 2016

Journal of Occupational &Amp; Environmental Medicine

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Objective A controlled human exposure study was conducted to investigate the impact of inhalational exposures to wood smoke PM2.5 on measured concentrations of airway and systemic inflammatory biomarkers. Methods Mimicking wildland firefighter activities, 10 participants were exposed to three doses of wood smoke PM2.5 (filtered-air, 250 µg/m3, and 500 µg/m3) while exercising on a treadmill. Exhaled breath condensate (EBC) and blood plasma samples were obtained pre-, immediately post-, and 1-hour post-exposure. 8-isoprostane, pH, and myeloperoxidase were measured in EBC while H2O2, surfactant protein D, and pentraxin-3 (PTX3) were measured in both EBC and plasma. Results Only pH, 8-isoprostane, and PTX3 displayed significant changes when comparing pre- and post- exposures. Conclusions Markers of inflammation and oxidative stress, including PTX3, pH, and 8-isoprostane in EBC and/or plasma, are sensitive to wood smoke inhalation, with further investigations warranted.

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The Long Pentraxin PTX3 as a Key Component of Humoral Innate Immunity and a Candidate Diagnostic for Inflammatory Diseases

Cited by 49 publications

References 133 publications

Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells

Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells

Immune and regulatory functions of neutrophils in inflammatory bone loss

Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations

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