The long noncoding RNA ZFAS1 facilitates bladder cancer tumorigenesis by sponging miR-329

Wang, Jinshan; Liu, Q.; Cheng, Xiaohua; Zhang, Wenyuan; Jin, Yan

doi:10.1016/j.biopha.2018.04.031

Cited by 40 publications

(32 citation statements)

References 27 publications

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“…7 Or, MCM3AP-AS1 promotes hepatocellular carcinoma progression. 9 Zinc finger protein multitype 2 antisense RNA 1 (ZFPM2-AS1) is a novel lncRNA which has not received much attention. 9 Zinc finger protein multitype 2 antisense RNA 1 (ZFPM2-AS1) is a novel lncRNA which has not received much attention.…”

Section: Introductionmentioning

confidence: 99%

lncRNA ZFPM2‐AS1 promotes proliferation via miR‐18b‐5p/VMA21 axis in lung adenocarcinoma

Xue

Tao

et al. 2019

J of Cellular Biochemistry

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Lung cancer has been proved to be one of the most common kinds of cancers around the globe. Meanwhile, as the predominant type of lung cancer, lung adenocarcinoma (LUAD) has received increasing attention in cancer research. Long noncoding RNAs (lncRNAs) are known to be associated with oncogenesis and progression of various cancers. However, many lncRNAs have not been thoroughly detected in LUAD. In this study, through bioinformatics analysis we found that zinc finger protein multitype 2 antisense RNA 1 (ZFPM2‐AS1) was associated with poor prognosis of LUAD patients. Also, ZFPM2‐AS1 was detected to be overexpressed in LUAD tissues and cells. Furthermore, ZFPM2‐AS1 could promote the proliferation of LUAD cells. Next, miR‐18b‐5p was found to bind with and negatively regulated by ZFPM2‐AS1. VMA21, target gene of miR‐18b‐5p, could bind with and be negatively regulated by miR‐18b‐5p. More importantly, both ZFPM2‐AS1 and VMA21 were found to be attached to the RNA‐induced silencing complex constructed from miR‐18b‐5p and Ago2. Also, ZFPM2‐AS1 could regulate the expression of VMA21. Therefore, ZFPM2‐AS1 were confirmed to regulate VMA21 by competitively binding with miR‐18b‐5p. Finally, rescue assays confirmed that ZFPM2‐AS1 could regulate LUAD cell proliferation via miR‐18b‐5p/VMA21 axis.

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Section: Introductionmentioning

confidence: 99%

lncRNA ZFPM2‐AS1 promotes proliferation via miR‐18b‐5p/VMA21 axis in lung adenocarcinoma

Xue

Tao

et al. 2019

J of Cellular Biochemistry

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“…27 In addition, ZFAS1 served as an oncogene in bladder cancer tumorigenesis by sponging miR-329. 28 In the current study, the miR-432-5p was predicted as a target of ZFAS1. A previous study revealed that miR-432-5p expression was significantly down-regulated in breast cancer tissues when compared with adjacent nontumour tissues.…”

Section: Discussionmentioning

confidence: 63%

“…ZFAS1 sponged miR‐484 to regulate cell proliferation and invasion in colorectal cancer cells and modulate tumour growth in nude mice . In addition, ZFAS1 served as an oncogene in bladder cancer tumorigenesis by sponging miR‐329 …”

Section: Discussionmentioning

confidence: 99%

ZFAS1 knockdown inhibits viability and enhances cisplatin cytotoxicity by up‐regulating miR‐432‐5p in glioma cells

Yang

Han

Feng

2019

Basic Clin Pharma Tox

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Background Long non‐coding RNA (lncRNA) zinc finger antisense 1 (ZFAS1) is a novel vital oncogenic lncRNA that is dysregulated in various types of cancers, including glioma. According to TargetScan prediction, miR‐432‐5p is a target of ZFAS1. Herein, we aimed to determine whether there was a correlation between ZFAS1 and miR‐432‐5p and to explore their roles in glioma. Methods The expression levels of ZFAS1 and microRNA (miR)‐432‐5p in clinical tissues and cell lines were measured using RT‐qPCR. Cell viability was detected using MTT assay. Cell apoptosis was examined using flow cytometry. The association between ZFAS1 and miR‐432‐5p was confirmed using luciferase reporter and RNA pull‐down assays. Results Zinc finger antisense 1 expression was up‐regulated, while miR‐432‐5p expression was down‐regulated in both glioma tissues and cells. Knockdown of ZFAS1 and miR‐432‐5p overexpression inhibited cell viability and enhanced the chemosensitivity of glioma cells to cisplatin. MiR‐432‐5p was a direct target of ZFAS1 in glioma cells. Inhibition of miR‐432‐5p blocked the effects of ZFAS1 knockdown on cell viability and cisplatin sensitivity. Conclusions Knockdown of ZFAS1 inhibited the viability and enhanced cisplatin sensitivity via targeting miR‐432‐5p in glioma cells.

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“…25,26 In addition, miR-149 was demonstrated to suppress cell invasive and migratory potentials in different types of cancers. [27][28][29] Our findings revealed miR-149 as a target for ZEB2-AS1. ZEB2-AS1 silence induced miR-149 F I G U R E 5 The correlation between ZEB2-AS1 expression levels and miR-149/PGF mRNA expression levels in placental tissues.…”

Section: Discussionmentioning

confidence: 94%

The decreased lncRNA ZEB2‐AS1 in pre‐eclampsia controls the trophoblastic cell line HTR‐8/SVneo's invasive and migratory abilities via the miR‐149/PGF axis

Gao

Sha

et al. 2019

J of Cellular Biochemistry

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Pre‐eclampsia (PE) is a pregnancy disease that causes maternal death and threatens the health of newborns. Accumulating evidence has revealed the essential roles of long noncoding RNAs (lncRNAs) in the progression of PE. The present investigation determined lncRNA ZEB2 antisense RNA 1 (ZEB2‐AS1) expression in PE and looked into the potential role of ZEB2‐AS1 in modulating trophoblastic cell functions. Quantitative real‐time polymerase chain reaction evaluated gene expression. Western blot analyzed the placental growth factor (PGF) protein level. Cell counting kit‐8 and Transwell invasion assays assessed the proliferative and invasive abilities of placental trophoblast cells, respectively. Wound healing assay determined cell migratory potentials. Dual‐luciferase reporter assay assessed the targeting relationship among ZEB2‐AS1, miR‐149, and PGF. Downregulation of lncRNA ZEB2‐AS1 was detected in placentas from patients with PE when compared with those from normal pregnancies. Moreover, ZEB2‐AS1 upregulation markedly promoted proliferative, migratory, and invasive potentials in HTR‐8/SVneo cells, while knockdown of ZEB2‐AS1 had the opposite effects. The effects on HTR‐8/SVneo cells mediated by ZEB2‐AS1 was correlated with the miR‐149/PGF axis. These findings indicate that ZEB2‐AS1 contributes to PE progression by affecting cell proliferative and invasive capacities via the miR‐149/PGF axis in HTR‐8/SVneo cells. In sum, we identified that ZEB2‐AS1 was a novel aberrantly expressed lncRNA in the placentas of PE patients and lncRNA ZEB2‐AS1 modulated trophoblastic cell line HTR‐8/SVneo's proliferative and invasive potentials via targeting the miR‐149/PGF axis.

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The long noncoding RNA ZFAS1 facilitates bladder cancer tumorigenesis by sponging miR-329

Cited by 40 publications

References 27 publications

lncRNA ZFPM2‐AS1 promotes proliferation via miR‐18b‐5p/VMA21 axis in lung adenocarcinoma

lncRNA ZFPM2‐AS1 promotes proliferation via miR‐18b‐5p/VMA21 axis in lung adenocarcinoma

ZFAS1 knockdown inhibits viability and enhances cisplatin cytotoxicity by up‐regulating miR‐432‐5p in glioma cells

The decreased lncRNA ZEB2‐AS1 in pre‐eclampsia controls the trophoblastic cell line HTR‐8/SVneo's invasive and migratory abilities via the miR‐149/PGF axis

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