The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation

Boiteux, Elisa Le; Guichet, Pierre‐Olivier; Masliantsev, Konstantin; Montibus, Bertille; Vaurs‐Barrière, Catherine; Gonthier-Gueret, Céline; Chautard, Emmanuel; Verrelle, Pierre; Karayan‐Tapon, Lucie; Fogli, Anne; Court, Franck; Arnaud, Philippe

doi:10.3390/ijms23094743

Cited by 6 publications

(3 citation statements)

References 52 publications

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“…HOXA-AS2 was found to be highly expressed in promyelocytic leukemia for the first time ( 55 ) and has been confirmed to be dysregulated in diverse tumor cells, such as osteosarcoma ( 37 ), glioma ( 56 ), NSCLC ( 20 ), CRC ( 57 ), and cervical cancer ( 35 ). It has also been proven to be involved in the biological behavior of many tumor cells as a high-risk factor.…”

Section: Discussionmentioning

confidence: 99%

“…These studies demonstrated that HOXA-AS2 is capable of oncogenic activity. It has been shown that HOXA-AS2 is related to various functions, including post-transcriptional regulation ( 56 ) and regulation of the pluripotency of stem cells ( 30 ). An overview of the molecular mechanisms governing HOX-AS2 ’s effects on various solid malignancies can be found in Table 3 .…”

Section: Discussionmentioning

confidence: 99%

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HOXA-AS2 may predict the prognosis of solid tumors among Chinese patients: A meta-analysis and bioinformatic analysis

Wang

Zhang²,

Deng³

et al. 2022

Front. Oncol.

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BackgroundHOXA cluster antisense RNA 2 (lncRNA HOXA-AS2) is a long noncoding RNA (lncRNA) that aberrantly expressed in various cancers and is closely associated with cancer progression. To overcome the limitation of small sample sizes that are inherent to single studies, a meta-analysis was conducted to explore the relationship between the expression level of HOXA-AS2 and cancer prognosis.MethodsCorrelational studies were retrieved by searching the databases of PubMed, Embase and Web of Science (up to August 10, 2022). The survival and prognosis data included overall survival (OS), and clinical parameters were gathered and analyzed.ResultsEighteen publications with 1181 patients who were diagnosed with solid tumors were ultimately included. The results showed that, compared with patients with low HOXA-AS2 expression, patients with high HOXA-AS2 expression tended to have poorer overall survival (OS) (HR= 2.52, 95% CI 1.87-3.38, P < 0.01) and shorter disease-free survival (DFS) (HR=7.19, 95% CI 3.20-16.17, P < 0.01). In addition, elevated HOXA-AS2 expression indicated a larger tumor size (OR =2.43, 95% CI 1.53–3.88,P < 0.01), more advanced TNM stage (OR=3.85, 95% CI 2.79-5.31, P < 0.01), earlier lymph node metastasis (LNM) (OR = 4.41, 95% CI 3.05-6.39, P < 0.01) and distant metastasis (DM) (OR= 2.96, 95% CI 1.87-4.7, P < 0.01). Furthermore, HOXA-AS2 expression was notassociated with age (OR=1.15, 95% CI 0.90-1.47), gender (OR=1.16, 95% CI 0.89-1.53), or tumor differentiation (OR=1.21, 95% CI 0.56-2.63). Moreover, aberrant HOXA-AS2 expression was related to drug sensitivity in various types of cancers.ConclusionThe overexpression of HOXA-AS2 predicted poor cancer prognosis in the Chinese population, including poor OS, DFS, TNM, LNM, and DM. HOXA-AS2 could serve as a promising prognostic biomarker and therapeutic target.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022352604.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

HOXA-AS2 may predict the prognosis of solid tumors among Chinese patients: A meta-analysis and bioinformatic analysis

Wang

Zhang²,

Deng³

et al. 2022

Front. Oncol.

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“…Furthermore, the downregulation of HOXA-AS2 induces cell apoptosis, arrests the cell cycle in the G1 phase, and inhibits metastasis and invasion in GBC [ 156 ]. In glioma, HOXA-AS2 affects the expression of E2F8, E2F1, ATF3, and STAT1, promoting the proliferation of glioma stem cells (GSCs) and enhancing their aggressiveness [ 157 ]. In CC, HOXA-AS2 enhances proliferation and metastasis by activating the Notch signaling pathway [ 158 ].…”

Section: Introductionmentioning

confidence: 99%

Role of HOXA1-4 in the development of genetic and malignant diseases

Wang,

Sun,

Cao

et al. 2024

Biomark Res

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The HOXA genes, belonging to the HOX family, encompass 11 members (HOXA1-11) and exert critical functions in early embryonic development, as well as various adult processes. Furthermore, dysregulation of HOXA genes is implicated in genetic diseases, heart disease, and various cancers. In this comprehensive overview, we primarily focused on the HOXA1-4 genes and their associated functions and diseases. Emphasis was placed on elucidating the impact of abnormal expression of these genes and highlighting their significance in maintaining optimal health and their involvement in the development of genetic and malignant diseases. Furthermore, we delved into their regulatory mechanisms, functional roles, and underlying biology and explored the therapeutic potential of targeting HOXA1-4 genes for the treatment of malignancies. Additionally, we explored the utility of HOXA1-4 genes as biomarkers for monitoring cancer recurrence and metastasis.

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