The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity
Debora Curci,
Biljana Stankovic,
Nikola Kotur
et al.
Abstract:IntroductionNuclear factor kappa B (NF-κB) is a key regulator of immune and inflammatory responses. Glucocorticoid drugs (GC) act through the glucocorticoid receptor (GR) as immunosuppressant also in pediatric patients inhibiting NF-κB activity. The long non-coding RNA GAS5 interacts with the GR, influencing GC activity. No data on the role of GAS5 on GR-dependent inhibition of NF-κB activity have been published.MethodsThis study investigated the impact of GAS5 on NF-κB activity in HeLa cells overexpressing GA… Show more
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