The long insular perforating arteries are essential cerebral perforating vessels too

Delion, Matthieu; Mercier, Philippe; Dinomais, Mickaël

doi:10.1007/s00701-015-2464-y

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…The integrity of this convergence zone may be critical for the motor outcome, as it contains redundant tracts and potential supports for the recovering process, which may be rendered unusable by the injury, as elegantly discussed elsewhere [Shelton and Reding, ]. Lesions of this area could be due either to Wallerian degeneration of fibers originating from the injured cortex in case of a large cortical infarct or to direct CSO ischemia as described in adults [Beckmann et al, ; Bogousslavsky and Regli, ] and related to occlusions of the insular perforating arteries [Delion et al, ].…”

Section: Discussionmentioning

confidence: 99%

Long term motor function after neonatal stroke: Lesion localization above all

Dinomais

Hertz‐Pannier

Groeschel

et al. 2015

Human Brain Mapping

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Motor outcome is variable following neonatal arterial ischemic stroke (NAIS). We analyzed the relationship between lesion characteristics on brain MRI and motor function in children who had suffered from NAIS. Thirty eight full term born children with unilateral NAIS were investigated at the age of seven. 3D T1- and 3D FLAIR-weighted MR images were acquired on a 3T MRI scanner. Lesion characteristics were compared between patients with and without cerebral palsy (CP) using the following approaches: lesion localization either using a category-based analysis, lesion mapping as well as voxel-based lesion-symptom mapping (VLSM). Using diffusion-weighted imaging the microstructure of the cortico-spinal tract (CST) was related to the status of CP by measuring DTI parameters. Whereas children with lesions sparing the primary motor system did not develop CP, CP was always present when extensive lesions damaged at least two brain structures involving the motor system. The VLSM approach provided a statistical map that confirmed the cortical lesions in the primary motor system and revealed that CP was highly correlated with lesions in close proximity to the CST. In children with CP, diffusion parameters indicated microstructural changes in the CST at the level of internal capsule and the centrum semiovale. White matter damage of the CST in centrum semiovale was a highly reproducible marker of CP. This is the first description of the implication of this latter region in motor impairment after NAIS. In conclusion, CP in childhood was closely linked to the location of the infarct in the motor system.

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Section: Discussionmentioning

confidence: 99%