The LONFLIT4-Concorde - Sigvaris Traveno Stockings in Long Flights (EcoTraS) Study

Abstract

Of 98 subjects none had thrombosis. The level of edema at inclusion was comparable in the 2 groups of subjects. After flights there was an average score of 6.4 (1.3) in the control group, while in the stockings group the score was on average 2.4 (SD 1), 2.6 times lower than in the control group (p < 0.05). In the control group 83% of the subjects had an evident increase in ankle circumference and volume that was visible at inspection and associated with discomfort. The control of edema with stockings was clear, considering both parametric data (circumference and volume) and nonparametric (analogue scale lines) measurements. Part II. In this part of the study 200 subjects at low-medium risk for DVT were contacted; 35 subjects were excluded for several nonmedical, travel-related problems or inconvenient evaluation time; the remaining 165 were randomized into 2 groups to evaluate prevention in flights lasting between 11 and 12 hours. The control group had no prophylaxis; the treatment group used Traveno stockings. Of the 83 included subjects in the stockings group and 82 in the control group (total 165), 146 subjects completed the study. Dropouts were due to low compliance or connection problems. Age/sex distribution were comparable. Of 75 subjects completing the study in the stockings group and 71 in the control group, none had thrombosis. The average level of edema at inclusion was comparable in the 2 groups (1.1). After the flight there was a score of 8.9 (2) in controls; in the stockings group the score was 2.56 (1.3) (p < 0.05). The control of edema and swelling with stockings even after 11 hours of flight was clear, considering both parametric (circumference, volume) and nonparametric (analogue scale lines) measurements. The tolerability of the stockings was very good and there were no complaints or side effects. In conclusion Sigvaris Traveno stockings are very effective in controlling edema in long-haul flights.

Graduated compression stockings as prophylaxis for flight‐related venous thrombosis: systematic literature review

“…Exercise, standing, stretching, drinking adequate water regularly, and avoiding constrictive clothes were suggested as another method of DVT prophylaxis in both treatment and control groups (Belcaro et al. 2001, 2002, 2003, Cesarone et al. 2003a, 2003b).…”

“…2002), LONFLIT 4‐2‐a (part I of the trial) (Cesarone et al. 2003b), LONFLIT 4‐2‐b (part II of the trial) (Cesarone et al. 2003b), LONFLIT 4‐3‐a (part I of the trial) (Cesarone et al.…”

Prevention of VTE in Nonsurgical Patients

“…All but one of these trials was conducted by a single group of investigators. 140,[143][144][145][146][147][148][149][150] Trials enrolled a mix of low-and increased-risk subjects based on risk factors for VTE, and most studies included persons taking fl ights of . 7 h. Asymptomatic DVT detected by screening ultrasound examination was the primary end point.…”

Air Travel and Venous Thromboembolism: A Systematic Review

“…These studies looked only at air travel and report a wide range of VTE risk, from none19,24,29 to 12% of travelers 26. As expected, studies of symptomatic VTE patients reported lower rates of VTE, about 0.5 PEs per million travelers presenting in the airport on the day of arrival10,17,21 and 27 VTEs (both PE and DVT) per million travelers presenting within 14 days of travel 23…”