The lonD gene is homologous to the lon gene encoding an ATP-dependent protease and is essential for the development of Myxococcus xanthus

Tojo, N; Inouye, Sumiko; Komano, Teruya

doi:10.1128/jb.175.14.4545-4549.1993

Cited by 76 publications

(68 citation statements)

References 19 publications

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“…In contrast, in bacteria that generally have a lower number of paralogues, such as B. subtilis and C. crescentus, there are two copies of lon and they have different roles in the cell (Serrano et al, 2001). Likewise, Myxococcus xanthus also has two copies of the lon gene : lonV, which is essential for vegetative growth (Tojo et al, 1993a), and lonD, which is required for development (Tojo et al, 1993b).…”

Section: Discussionmentioning

confidence: 99%

The lon gene, encoding an ATP-dependent protease, is a novel member of the HAIR/HspR stress-response regulon in actinomycetes

et al. 2002

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Members of a family of ATP-dependent proteases related to Lon fromEscherichia coli are present in most prokaryotes and eukaryotes. These proteases are generally reported to be heat induced, and various regulatory systems have been described. The authors cloned and disrupted the lon gene and studied the regulation of its expression in Streptomyces lividans. lon is negatively regulated by the HspR/HAIR repressor/operator system, suggesting that Lon is produced concomitantly with the other members of this regulon, DnaK and ClpB. The lon mutant grew more slowly than the wild-type and spore germination was impaired at high temperature. Nevertheless its cell cycle was not greatly affected and it sporulated normally.

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Section: Discussionmentioning

confidence: 99%

The lon gene, encoding an ATP-dependent protease, is a novel member of the HAIR/HspR stress-response regulon in actinomycetes

et al. 2002

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“…Similarly, M. xanthus encodes several pairs of putatively duplicated proteins expressed during different life stages (for example, Lon [36,37] and serine-threonine kinase [27,36,37]). Similarly, DNA repair may be different at each stage, relying on distinct RecA proteins.…”

Section: Discussionmentioning

confidence: 99%

Bacterial classifications derived from recA protein sequence comparisons

1995

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RecA protein sequences from 62 eubacterial sources were compared with one another and relative to one archaebacterial RecA-like and a number of eukaryotic RecA-like sequences. Pairwise similarity scores were determined by a novel method based on significant segment pair alignment. The sequences of different species were grouped on the basis of mutually high similarity scores within groups and consistency of score ranges in comparison to other groups. Following this protocol, the ␥-proteobacteria can be subclassified into two major groups, those of mostly vertebrate hosts and those of mostly soil habitat. The ␣-proteobacterial sequences also divide into two distinct groups, whereas classification of the ␤-proteobacteria is more complex.

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“…Myxobacteria are proficient predators of whole colonies of other soil microbes. MYXXA encodes many duplicated proteins expressed during the different life stages, e.g., Lon (9) and serine-threonine protein kinases (10). BDEBA is ubiquitous in terrestrial and aquatic habitats.…”

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confidence: 99%

Distinguishing features of δ-proteobacterial genomes

Karlin¹,

Brocchieri²,

Mrázek

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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We analyzed several features of five currently available ␦-proteobacterial genomes, including two aerobic bacteria exhibiting predatory behavior and three anaerobic sulfate-reducing bacteria. The ␦ genomes are distinguished from other bacteria by several properties: (i) The ␦ genomes contain two ''giant'' S1 ribosomal protein genes in contrast to all other bacterial types, which encode a single or no S1; (ii) in most ␦-proteobacterial genomes the major ribosomal protein (RP) gene cluster is near the replication terminus whereas most bacterial genomes place the major RP cluster near the origin of replication; (iii) the ␦ genomes possess the rare combination of discriminating asparaginyl and glutaminyl tRNA synthetase (AARS) together with the amidotransferase complex (Gat CAB) genes that modify Asp-tRNA Asn into Asn-tRNA Asn and Glu-tRNA Gln into Gln-tRNA Gln ; (iv) the TonB receptors and ferric siderophore receptors that facilitate uptake and removal of complex metals are common among ␦ genomes; (v) the anaerobic ␦ genomes encode multiple copies of the anaerobic detoxification protein rubrerythrin that can neutralize hydrogen peroxide; and (vi) 54

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The lonD gene is homologous to the lon gene encoding an ATP-dependent protease and is essential for the development of Myxococcus xanthus

Cited by 76 publications

References 19 publications

The lon gene, encoding an ATP-dependent protease, is a novel member of the HAIR/HspR stress-response regulon in actinomycetes

The lon gene, encoding an ATP-dependent protease, is a novel member of the HAIR/HspR stress-response regulon in actinomycetes

Bacterial classifications derived from recA protein sequence comparisons

Distinguishing features of δ-proteobacterial genomes

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