We present the first dedicated observations of Interplanetary Scintillation (IPS) with the Murchison Widefield Array (MWA). We have developed a synthesis imaging technique, tailored to the properties of modern "large-N" low-frequency radio telescopes. This allows us to image the variability on IPS timescales across 900 square degrees simultaneously. We show that for our observations, a sampling rate of just 2 Hz is sufficient to resolve the IPS signature of most sources. We develop tests to ensure that IPS variability is separated from ionospheric or instrumental variability. We validate our results by comparison with existing catalogues of IPS sources, and nearcontemporaneous observations by other IPS facilities. Using just five minutes of data, we produce catalogues at both 79 MHz and 158 MHz, each containing over 350 scintillating sources. At the field centre we detect approximately one scintillating source per square degree, with a minimum scintillating flux density at 158 MHz of 110 mJy, corresponding to a compact flux density of approximately 400 mJy. Each of these sources is a known radio source, however only a minority were previously known to contain sub-arcsecond components. We discuss our findings and the prospects they hold for future astrophysical and heliospheric studies.