“…Zirconia-toughened alumina (ZTA), on the other hand, is a ceramic composite material widely used as biocompatible implant material, which has a low potential for pathological inflammatory processes due to low wear rate and biologic inertness of the wear particles [ 9 , 10 , 11 , 12 , 13 ]. Importantly, it is believed that the local toxicity of metal ions creates local immune deficiency by creating a microenvironment of immune cell migration, possibly also facilitating bacteria growth at the implant site [ 14 ]. Indeed, the presence of any implanted medical device reduces the required bacteria concentration to induce an infection by 100,000 times, and different patient characteristics (e.g., age or pre-existing health conditions) can further promote an infection [ 15 ].…”