The local immune response to Escherichia coli O and K antigen in experimental pyelonephritis.

Smith, James W.; Kaijser, B

doi:10.1172/jci108469

Cited by 30 publications

(21 citation statements)

References 23 publications

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“…Such a process, if operative in vivo, might be a mechanism by which pathogenic bacteria and fungi establish themselves as secondary invaders in transplant recipients with primary CMV infections (6)(7)(8) Antigen preparation. Purified 06 lipopolysaccharide was prepared by a phenol-water extraction method (9). Antiserum preparation.…”

Section: Introductionmentioning

confidence: 99%

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Antibody-mediated bacterial adhesion to cytomegalovirus-induced Fc receptors. Potential relationship to secondary infections complicating herpesvirus infections.

Mackowiak¹,

Marling-Cason²,

Smith³

et al. 1984

J. Clin. Invest.

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Abstract. Cytomegalovirus (CMV) and other viruses within the herpes group have recently been shown to induce Fc receptors in infected monolayers. We have examined the possibility that such receptors might facilitate the adherence of antibody-coated bacteria to CMVinfected cells. To do this, we infected confluent human embryonic lung (HEL) cell monolayers with CMV (strain AD 169) and then used a double radiolabel assay to measure adherence of Escherichia colt 06 to both infected and control monolayers. We examined infected monolayers 48 h after viral seeding, at which time 30-60% of the cells exhibited characteristic cytopathic changes. We compared the adherence of untreated E. coli 06 with the adherence of E. coli 06 that had been preincubated for 1 h at 370C with either nonimmune or anti-E. coli 06 antiserum. Pretreatment of the E. coli 06 with specific antiserum significantly enhanced its adherence to CMVinfected, but not to control, monolayers (P < 0.01 by the Mann-Whitney U test). We did not see such enhancement when we used anti-E. coli 06 antiserum to treat a nontypable E. colt. The augmented adherence of antibodycoated E. colt 06 to CMV-infected monolayers was abrogated by pretreating the monolayers with nonimmune serum or purified Fc fragments, but not by pretreating with IgA, IgM, or 1 mM trypan blue. Preincubating HEL cell monolayers with 100 U/ml human leukocyte interferon for 72 h at 370C did not affect the adherence of antibody-coated E. coli 06 to the monolayers.

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Section: Introductionmentioning

confidence: 99%

“…Animals were bled at weekly intervals thereafter. Serum was separated and examined for antibody titer by enzyme-linked immunosorbent assay (9). Antiserum used in these experiments had a titer of 5.0 logl0.…”

Section: Introductionmentioning

confidence: 99%

Antibody-mediated bacterial adhesion to cytomegalovirus-induced Fc receptors. Potential relationship to secondary infections complicating herpesvirus infections.

Mackowiak¹,

Marling-Cason²,

Smith³

et al. 1984

J. Clin. Invest.

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“…Immunologically. K antigens are poor immunogens, inducing relatively low anti body titers [69]. Presumably all bacteria with K antigens could initiate acute pyelonephri tis.…”

Section: Core Polysaccharide (Region 2)mentioning

confidence: 99%

Medical Progress: Immunobiology and Genetic Factors in the Pathogenesis of Pyelonephritis

Hemstreet

Cruse

Feye

1984

Pathol Immunopathol Res

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“…INTRODUCTION Although the epidemiology and natural history of renal infection is well documented, convincing studies that explain the peculiar susceptibility of renal tissue to infection are lacking. Recently, a number of investigators have studied the nature of the immune response to renal infection and have characterized the biology of the host response to infectious challenge (1)(2)(3)(4)(5)(6)(7)(8).…”

mentioning

confidence: 99%

Modification by Suppressor Cells and Serum Factors of the Cell-Mediated Immune Response in Experimental Pyelonephritis

Miller¹,

Scott²,

Stewart³

et al. 1978

J. Clin. Invest.

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The local immune response to Escherichia coli O and K antigen in experimental pyelonephritis.

Cited by 30 publications

References 23 publications

Antibody-mediated bacterial adhesion to cytomegalovirus-induced Fc receptors. Potential relationship to secondary infections complicating herpesvirus infections.

Antibody-mediated bacterial adhesion to cytomegalovirus-induced Fc receptors. Potential relationship to secondary infections complicating herpesvirus infections.

Medical Progress: Immunobiology and Genetic Factors in the Pathogenesis of Pyelonephritis

Modification by Suppressor Cells and Serum Factors of the Cell-Mediated Immune Response in Experimental Pyelonephritis

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