The Local Immune Mechanisms Involved in the Formation of Endometriotic Lesions

Antsiferova, Yulia S.; Sotnikova, N. Yu.

doi:10.5772/29965

Cited by 2 publications

(2 citation statements)

References 78 publications

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“…Likely, the impairment of the expression of macrophages specific membrane receptors might be responsible for ineffective removing of endometrial cells from peritoneal cavity by macrophages. In our previous work we have shown that expression of the membrane scavenger receptors SR-A1 and SR-B, responsible for the removing of cellular debris from peritoneal cavity, by peritoneal macrophages of women with endometriosis is significantly reduced in comparison to that in healthy fertile women [ 5 ]. Experimentally we had also demonstrated that the decreased expression of these scavenger receptors on the surface membrane of macrophages resulted in the impairment of macrophages interaction with the autologous endometrial cells [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…In our previous work we have shown that expression of the membrane scavenger receptors SR-A1 and SR-B, responsible for the removing of cellular debris from peritoneal cavity, by peritoneal macrophages of women with endometriosis is significantly reduced in comparison to that in healthy fertile women [ 5 ]. Experimentally we had also demonstrated that the decreased expression of these scavenger receptors on the surface membrane of macrophages resulted in the impairment of macrophages interaction with the autologous endometrial cells [ 5 ]. It is known that scavenger receptors belong to the large family of signaling pattern-recognition receptors or PRRs [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Different Effects of the Immunomodulatory Drug GMDP Immobilized onto Aminopropyl Modified and Unmodified Mesoporous Silica Nanoparticles upon Peritoneal Macrophages of Women with Endometriosis

Antsiferova

Sotnikova

Parfenyuk

2013

BioMed Research International

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The aim of the present work was to compare in vitro the possibility of application of unmodified silica nanoparticles (UMNPs) and modified by aminopropyl groups silica nanoparticles (AMNPs) for topical delivery of immunomodulatory drug GMDP to the peritoneal macrophages of women with endometriosis. The absence of cytotoxic effect and high cellular uptake was demonstrated for both types of silica nanoparticles. The immobilization of GMDP on the UMNPs led to the suppression of the stimulatory effect of GMDP on the membrane expression of scavenger receptors SR-AI and SR-B, mRNAs expression of NOD2 and RAGE, and synthesis of proteolytic enzyme MMP-9 and its inhibitor TIMP-1. GMDP, immobilized onto AMNPs, enhanced the initially reduced membrane expression of SRs and increased NOD2, RAGE, and MMP-9 mRNAs expression by macrophages. Simultaneously high level of mRNAs expression of factors, preventing undesirable hyperactivation of peritoneal macrophages (SOCS1 and TIMP-1), was observed in macrophages incubated in the presence of GMDP, immobilized onto AMNPs. The effect of AMNPs immobilized GMDP in some cases exceeded the effect of free GMDP. Thus, among the studied types of silica nanoparticles, AMNPs are the most suitable nanoparticles for topical delivery of GMDP to the peritoneal macrophages.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%