The Local Anesthetic and Pain Relief Activity of Alkaloids

Abstract

Alkaloids have been known for several centuries and have been mainly obtained from natural sources that presented important properties with biochemical, pharmacological, and medical effects in living organisms. Alkaloids are derived from amino acids like other important molecules in the functioning of life in our body. Hence, alkaloids are considered as pharmacologically important. Alkaloids are secondary metabolites widely distributed in leaves, stem, root, and fruits of plants which synthesize them. However, administration and consumption of them at right doses are beneficial in terms of health; excess doses will be definitely poisonous and may cause even death. The pharmacological activities of alkaloids are quite diverse. They are important natural products with a wide range of medicinal properties including relief of pain (e.g.

Vegetal Compounds as Sources of Prophylactic and Therapeutic Agents in Dentistry

“…Thus, alkaloids such as berberine show antibacterial activity on A. actinomycetemcomitans and P. gingivalis species, and it is observed that the mechanism of action consist in inhibition of collagenase enzyme activity [33]. Additionally, alkaloids find their practical utility in dentistry as local anesthetics, being used in various dental interventions [34]. These compounds also have a beneficial effect in viral infections due to their ability to stimulate the host's immune system by increasing interferon synthesis and stimulating macrophage activity.…”

Catalytic Function of Cu (I) and Cu (II) in Total Synthesis of Alkaloids

“…Alkaloids are secondary metabolites, broadly spread in a different part of plants such as leaves, stem, root, fruits, etc.. [1] They have exhibited significant biological activities in living organisms such as anticholinesterase action, [2] antioxidant, [3] anxiolytic, [4] antimicrobial, [5] anti-HIV, [6] antiparastic, [7] antiinflammatory [8] and antidepressant. [9] Despite the extensive research and work on the extraction, separation and purification of several alkaloids, due to their intricate structures and tedious processes, only a small number of them could be provided from natural sources in commercial amounts.…”

“…[9] Despite the extensive research and work on the extraction, separation and purification of several alkaloids, due to their intricate structures and tedious processes, only a small number of them could be provided from natural sources in commercial amounts. [1] Thus, the improvements of various effective and useful protocols for their total syntheses have still encouraged several research groups, worldwide.…”

Phosphate-Based Self-Immolative Linkers for the Delivery of Amine-Containing Drugs

“…Drugs containing an amino group are key pharmaceutical agents, covering a broad spectrum of biological actions and displaying anti-inflammatory [ 1 ], anticancer [ 2 , 3 ], antimicrobial [ 4 , 5 ], and pain-relieving properties [ 6 ]. Currently, 542 drugs containing an amino group have already been approved for the EU market, according to the drug bank online ( , accessed on 15 July 2021).…”