The Local Action of 20-Methylcholanthrene and Sex Hormones on Prostatic Grafts

Abstract

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On the significance of sex hormones in producing experimental prostate tumor in the rat.

“…Estrogen dominancy promoted the transition from adenoma to adenocarcinoma. 4 In the next place, it is also an im-portant problem to establish the method which makes exactly transplanted carcinoma by using the primary tumor focus in the experimental animals. Figuratively speaking, importance of transplanted carcinoma in experimental tumor study is about the same as that of successive pure cultivated strain of microorganisms in the field of bacteriology.…”

Prostatic Adenocarcinoma Carcinogenesis and Growth

“…Sheets of prostatic epithelium were wrapped around methylcholanthrene pellets and grafted subcutaneously into the abdomens of syngeneic mice. This technique was refined by the addition of estrogens that enhance the carcinogenic potential 57 . The most successful technique, using a combination of hormonal manipulation followed by subsequent treatment with a carcinogen, consisted of castrating rats, and then treating them with 9,10,dimethyl‐1,2 benzanthracene 58 .…”