The LNG-IUS study on adenomyosis: a 3-year follow-up study on the efficacy and side effects of the use of levonorgestrel intrauterine system for the treatment of dysmenorrhea associated with adenomyosis

Sheng, Jie; Zhang, Wei Yuan; Zhang, Jian Ping; Lü, Dan

doi:10.1016/j.contraception.2008.11.004

Cited by 167 publications

(103 citation statements)

References 25 publications

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“…While LNG-IUD was shown to be effective in the long-term management of menorrhagia related to uterine leiomyoma and adenomyosis, studies concerning the effectiveness of P in the reduction of uterine and leiomyoma volumes have revealed inconsistent results, showing LNG-IUD to be either a useless (1,3,(6)(7)(8) or an effective (9,10) measure in the regression of the uterine and tumoral enlargement. Therefore, the present study was designed to evaluate the effectiveness of LNG-IUD in the treatment of myoma-related menorrhagia in terms of menstrual blood loss reduction, improvement in hematological parameters indicative of anemia, and the regression in uterus and leiomyoma volumes.…”

mentioning

confidence: 94%

Levonorgestrel-releasing intrauterine device insertion ameliorates leiomyoma-dependent menorrhagia among women of reproductive age without a significant regression in the uterine and leiomyoma volumes

Naki

Tekcan

Özcan

et al. 2010

Fertility and Sterility

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mentioning

confidence: 94%

Levonorgestrel-releasing intrauterine device insertion ameliorates leiomyoma-dependent menorrhagia among women of reproductive age without a significant regression in the uterine and leiomyoma volumes

Naki

Tekcan

Özcan

et al. 2010

Fertility and Sterility

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“…Along with the high contraceptive efficacy, LNG-IUS has shown benefits and improvement of symptoms in menorrhagia, adenomyosis and endometriosis. 4,5 LNG-IUS device has also been found to be cost-effective with less side effects and to increase the quality of life (QOL). 6 The QOL of women treated with the LNG-IUS is markedly improved, causing high levels of patient satisfaction.…”

Section: Introductionmentioning

confidence: 99%

Role of levonorgestrel releasing intrauterine device in management of heavy menstrual bleeding: a conservative approach

Singh

Bharati

Prasad

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Heavy menstrual bleeding (HMB) is defined as prolonged (>7 days) or excessive menstrual blood loss greater than or equal to 80 ml per menstrual cycle. The objective of the study was to assess the efficacy, acceptability and side effects of LUS IUS in women with heavy menstrual bleeding.Methods: 42 women with heavy menstrual bleeding with or without associated dysmenorrhoea or chronic pelvic pain and had no contraindication to IUS insertion were included in the study. Patients having active genital tract infection, suspicion of pregnancy, uterine fibroids >2.5 cm in size or sub mucosal distorting the uterine cavity, uterine size >12 weeks, atypical endometrial hyperplasia or malignancy, abnormal cervical cytology, coagulopathy or liver disease were excluded from the study. Preliminary endometrial biopsy was done to rule out malignancy and LNG IUS was inserted under anaesthesia. Women were followed for 3,6,12 and 24 months post insertion.Results: In first 3 months, 20% patients achieved normal menstrual cycle, and at 6 months 44.44% had scanty menstrual flow and after 1 year of use 81.5% achieved amenorrhoea. In initial 3 months 37.5% patients had irregular heavy bleeding, which reduced to 13.89% at 6 months and 0% at 1 year follow up. Irregular spotting was second most complaint in 32.5% patients in initial 3 months that persisted in 7.4% patients at 1year follow up. In 5.0% patients, there was spontaneous expulsion of the device in first 3 menstrual cycles. After 3 months of use 57.5% patients were satisfied with the device and at the end of 1 year 92.5% were satisfied.Conclusions: LNG IUS is highly effective in controlling blood loss, well tolerated and better alternative for hysterectomy with higher user satisfaction in all age group of women.

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“…The effects of medical treatments, such as progestin, oral contraceptives or GnRH agonists are transient [3]. Recent studies have demonstrated that levonorgestrel-releasing intrauterine devices are effective for the management of adenomyosis in women with dysmenorrhea and menorrhagia [16,17]. However, the adverse effects of prolonged exposure to progestin treatment, such as headache, breast tenderness, seborrhea, acne and weight gain, may diminish long-term patient satisfaction [18].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Efficacy of Laparoscopic or Robotic Adenomyomectomy with or without Medical Treatment for Severely Symptomatic Adenomyosis

Chong

Lee

Hong

et al. 2016

Gynecol Obstet Invest

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Background/Aims: To determine the long-term efficacy of laparoscopic or robotic adenomyomectomy with or without gonadotropin-releasing hormone (GnRH) for the treatment of severely symptomatic adenomyosis. Methods: Between August 2008 and May 2011, we prospectively observed 33 patients who underwent laparoscopic or robotic adenomyomectomy with uterine artery ligation for the treatment of symptomatic adenomyosis. Seventeen patients (52%) received 3-course GnRH agonist treatment after the adenomyomectomy. Results: The mean operating time was 147.4 ± 52.0 min, and the mean blood loss was 36.1 ± 37.4 ml. Postoperative complications occurred in 5 patients, including 4 cases of febrile morbidity, 1 case of ileus and 1 case of pelvic abscess. Patients had statistically significant symptom relief during the 3-year follow-up period. Four of the 33 patients (12%) showed symptom relapse; 3 patients showed a relapse with dysmenorrhea and 1 patient showed a relapse with menorrhagia. There were no significant differences in terms of therapeutic outcomes between surgical-only and surgical-medical treatment. Conclusion: Laparoscopic or robotic adenomyomectomy was feasible and safe for women with severely symptomatic adenomyosis who requested uterine preservation. Moreover, this procedure provided long-term symptom control, regardless of postoperative GnRH agonist administration.

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The LNG-IUS study on adenomyosis: a 3-year follow-up study on the efficacy and side effects of the use of levonorgestrel intrauterine system for the treatment of dysmenorrhea associated with adenomyosis

Cited by 167 publications

References 25 publications

Levonorgestrel-releasing intrauterine device insertion ameliorates leiomyoma-dependent menorrhagia among women of reproductive age without a significant regression in the uterine and leiomyoma volumes

Levonorgestrel-releasing intrauterine device insertion ameliorates leiomyoma-dependent menorrhagia among women of reproductive age without a significant regression in the uterine and leiomyoma volumes

Role of levonorgestrel releasing intrauterine device in management of heavy menstrual bleeding: a conservative approach

Long-Term Efficacy of Laparoscopic or Robotic Adenomyomectomy with or without Medical Treatment for Severely Symptomatic Adenomyosis

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