The lncRNA ZEB1-AS1 sponges miR-181a-5p to promote colorectal cancer cell proliferation by regulating Wnt/β-catenin signaling

Lv, Shaoyan; Shan, Ti‐Dong; Pan, Xinting; Tian, Zibin; Liu, Xi-Shuang; Liu, Fuguo; Sun, Xue‐Guo; Hou, Xue; Li, Xinhua; Han, Yang; Sun, Lijuan; Chen, Li; Zhang, Lingyun

doi:10.1080/15384101.2018.1471317

Cited by 63 publications

(46 citation statements)

References 31 publications

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“…As shown in Figure 1 , a total of fourteen articles were included in the current meta-analysis 9 , 15 - 27 . Additionally, Table 1 summarized the main characteristics of the fourteen studies included in the present meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

The prognostic value of long noncoding RNA ZEB1-AS1 on clinical outcomes in human cancer

Wu¹,

Ding²,

Wei³

et al. 2018

J. Cancer

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Background: Although growing evidence have demonstrated that long non-coding RNA ZEB1-AS1 was aberrantly expressed in various types of cancers and can be used as a prognostic marker in cancer, the results remain inconclusive. Therefore, we performed this meta-analysis to evaluate the prognostic value of ZEB1-AS1 in human cancer.Methods: A literature survey was conducted for all eligible studies by searching the following online databases: PubMed and Embase. The pooled odds ratios (ORs) or hazard ratios (HRs) with a 95 % confidence interval (95 % Cl) were computed to demonstrate its prognostic value.Results: A total of 14 studies with 1096 individuals were included to evaluate the association of ZEB1-AS1 with clinicopathological features and overall survival (OS). In the pooled analyses stratified by clinicopathological features, ZEB1-AS1 expression was significantly related to depth of tumor (OR=2.92, 95% CI 1.22-7.02), poor histological differentiation (OR=2.72, 95% CI: 1.92-3.86), lymph node metastasis (OR=3.93, 95% CI: 2.65-5.84), distant metastasis (OR=5.34, 95% CI: 2.85-10.02) and tumor stage (OR=2.46, 95% CI 1.42-4.24), but not to tumor size (OR=1.25, 95% CI 0.79-1.96). Altered ZEB1-AS1 expression was found to be an indicator of worse prognosis in OS (HR = 1.94, 95% CI: 1. 66-2.22) among tumor patients.Conclusions: High ZEB1-AS1expression was associated poor clinical outcome and it can serve as a novel predictive biomarker in various cancers.

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Section: Resultsmentioning

confidence: 99%

The prognostic value of long noncoding RNA ZEB1-AS1 on clinical outcomes in human cancer

Wu¹,

Ding²,

Wei³

et al. 2018

J. Cancer

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“…However, the role of lncRNA MIAT in Cp or HI injury-induced brain injury is unclear. Numerous studies have shown that lncRNAs involve in biological or pathological process through regulating miRNAs [22,23]. miR-211 is a neuron-related miRNA that can inhibit neuronal differentiation in Alzheimer's disease [24].…”

Section: Introductionmentioning

confidence: 99%

LncRNA MIAT overexpression reduced neuron apoptosis in a neonatal rat model of hypoxic-ischemic injury through miR-211/GDNF

Zhao

Jian

et al. 2018

Cell Cycle

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Objective: To investigate the underlying mechanism of lncRNA myocardial infarction-associated transcript (MIAT) in hypoxic-ischemic (HI)-induced neonatal cerebral palsy. Materials and methods: Neonatal rat model of HI injury was established to detect the motor function. LncRNA MIAT, miR-211, glial cell line-derived neurotrophic factor (GDNF) and caspase-3 expressions were measured by qRT-PCR or western blot. The apoptosis of Neuro2A cells was detected by flow cytometry. RNA immunoprecipitation (RIP) and RNA pull-down assays were performed to confirm the interaction between MIAT and miR-211. Results: Compared with control group, lncRNA MIAT and GDNF were downregulated in striatal tissues of neonatal rats in HI group and oxygen glucose deprivation (OGD)-induced ischemic injury of Neuro2A cells, whereas miR-211 was up-regulated in striatal tissues of HI group and OGDinduced ischemic injury of Neuro2A cells. LncRNA MIAT interacted with miR-211, and lncRNA MIAT overexpression reduced neuron apoptosis through miR-211. Besides, GDNF expression was positively regulated by lncRNA MIAT and negatively regulated by miR-211 in Neuro2A cells. In vivo experiment proved MIAT promoted motor function and relieved HI injury. Conclusion: MIAT overexpression reduced apoptosis of Neuro2A cells through miR-211/GDNF, which relieved HI injury of neonatal rats.

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“…Cheng R et al revealed that ZEB1‐AS1 depletion suppressed the growth, migration, invasion and EMT in cervical cancer, which may be achieved by inhibiting ZEB1 expression . Moreover, ZEB1‐AS1 depletion markedly restrained the proliferation and induced apoptosis in colorectal cancer, whereas ZEB1‐AS1 elevation elicited the opposite effect . A recent investigation demonstrated that ZEB1‐AS1 silencing triggered cell proliferation suppression and decreases in the cell number in S phase in liver cancer by targeting miR‐365a‐3p .…”

Section: Discussionmentioning

confidence: 99%

LncRNA ZEB1‐AS1 down‐regulation suppresses the proliferation and invasion by inhibiting ZEB1 expression in oesophageal squamous cell carcinoma

Zhao

Wang

Zhang

et al. 2019

J Cellular Molecular Medi

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Multiple studies have unveiled that long non‐coding RNAs (lncRNAs) play a pivotal role in tumour progression and metastasis. However, the biological role of lncRNA ZEB1‐AS1 in oesophageal squamous cell carcinoma (ESCC) remains under investigation, and thus, the current study was to investigate the functions of ZEB1‐AS1 in proliferation and invasion of ESCC. Here, we discovered that ZEB1‐AS1 and ZEB1 were markedly up‐regulated in ESCC tissues and cells relative to their corresponding normal control. ZEB1‐AS1 and ZEB1 overexpressions were both related to TNM staging and lymph node metastasis as well as poor prognosis in ESCC. The hypomethylation of ZEB1‐AS1 promoter triggered ZEB1‐AS1 overexpression in ESCC tissues and cells. In addition, ZEB1‐AS1 knockdown mediated by siRNA markedly suppressed the proliferation and invasion in vitro in EC9706 and TE1 cells, which was similar with ZEB1 siRNA treatment, coupled with EMT alterations including the up‐regulation of E‐cadherin level as well as the down‐regulation of N‐cadherin and vimentin levels. Notably, ZEB1‐AS1 depletion dramatically down‐regulated ZEB1 expression in EC9706 and TE1 cells, and ZEB1 overexpression obviously reversed the inhibitory effects of proliferation and invasion triggered by ZEB1‐AS1 siRNA. ZEB1‐AS1 shRNA evidently inhibited tumour growth and weight, whereas ZEB1 elevation partly recovered the tumour growth in ESCC EC9706 and TE1 xenografted nude mice. In conclusion, ZEB1‐AS1 overexpression is tightly involved in the development and progression of ESCC, and it exerts the antitumour efficacy by regulating ZEB1 level in ESCC.

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The lncRNA ZEB1-AS1 sponges miR-181a-5p to promote colorectal cancer cell proliferation by regulating Wnt/β-catenin signaling

Cited by 63 publications

References 31 publications

The prognostic value of long noncoding RNA ZEB1-AS1 on clinical outcomes in human cancer

The prognostic value of long noncoding RNA ZEB1-AS1 on clinical outcomes in human cancer

LncRNA MIAT overexpression reduced neuron apoptosis in a neonatal rat model of hypoxic-ischemic injury through miR-211/GDNF

LncRNA ZEB1‐AS1 down‐regulation suppresses the proliferation and invasion by inhibiting ZEB1 expression in oesophageal squamous cell carcinoma

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