The lncRNA Ftx/miR-382-5p/Nrg1 axis improves the inflammation response of microglia and spinal cord injury repair

Xiang, Weineng; Jiang, Lin; Zhou, Yun; Li, Zhiyue; Zhao, Qun; Wu, Tianding; Cao, Yong; Zhou, Jiahui

doi:10.1016/j.neuint.2020.104929

Cited by 29 publications

(18 citation statements)

References 43 publications

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“…Increased Nrg1 attenuates the expressions of inflammation factors (e.g., iNOS, IL-6, TNF-α, and IL-1β) in LPS-treated BV2 cells. As a result, increased Ftx relieves microglia inflammation response through the miR-382-5p-Nrg1 axis (Xiang et al, 2021). In addition, this study also indicated that over-expressed Ftx can suppress inflammation response and improve functional recovery in the SCI mouse model (Xiang et al, 2021).…”

Section: Spinal Cord Injurymentioning

confidence: 68%

“…As a result, increased Ftx relieves microglia inflammation response through the miR-382-5p-Nrg1 axis (Xiang et al, 2021). In addition, this study also indicated that over-expressed Ftx can suppress inflammation response and improve functional recovery in the SCI mouse model (Xiang et al, 2021). Exosomes, which belong to extracellular vesicles (EVs), can be secreted by all cells and carry various materials, including proteins, lipids, mRNA, ncRNAs, etc.…”

Section: Spinal Cord Injurymentioning

confidence: 87%

“…In this review, the lncRNA/circRNA-miRNA-mRNA regulatory network also exists in microglia and astrocyte mediated neurological diseases, including SCI (Figure 1; Shao et al, 2020; FIGURE 1 | The lncRNA/circRNA-miRNA-mRNA regulatory network in microglia and astrocyte regulated neurological diseases. Xu S. et al, 2020;Zhao Q. et al, 2020;Cui et al, 2021;Xiang et al, 2021;Chen et al, 2022), TBI (He et al, 2021;Liu N. et al, 2021;Meng et al, 2021), cerebral IRI (Figure 1; Wang et al, 2020c;Yang et al, 2021), stroke (Figure 1; Qi et al, 2017;Han B. et al, 2018;Tian et al, 2021;Zhang M. et al, 2021), epilepsy (Figure 1; Feng et al, 2020;Han C. L. et al, 2020;Wan and Yang, 2020;Xiaoying et al, 2020), neuropathic pain (Figure 1; Chen M. et al, 2020), PD (Figure 1; Cao et al, 2018Cao et al, , 2021, and depression (Figure 1; . We also found that some therapies can impair the ncRNA-glial cell axis and thus inhibit disease development.…”

Section: Discussionmentioning

confidence: 99%

“…MiR-382-5p targets 3 UTR of Neuregulin-1 (Nrg1). MiR-382-5p deletion stimulated by its inhibitor can remarkably increase Nrg1 expression in BV2 cells (Xiang et al, 2021). LncRNA Ftx expression is markedly decreased in tissues collected from SCI mice and in LPSstimulated BV2 cells.…”

Section: Spinal Cord Injurymentioning

confidence: 94%

“…Ftx targets miR-382-5p and represses its expression. Besides, Ftx also competes with Nrg1 for miR-382-5p binding, resulting in suppressing miR-382-5p repression on Nrg1 expression (Xiang et al, 2021). Ftx over-expression increases Nrg1 expression levels through miR-382-5p.…”

Section: Spinal Cord Injurymentioning

confidence: 99%

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Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Chen

Lai

Wang

et al. 2021

Front. Mol. Neurosci.

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Microglia and astrocytes maintain tissue homeostasis in the nervous system. Both microglia and astrocytes have pro-inflammatory phenotype and anti-inflammatory phenotype. Activated microglia and activated astrocytes can contribute to several neurological diseases. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), two groups of non-coding RNAs (ncRNAs), can function as competing endogenous RNAs (ceRNAs) to impair the microRNA (miRNA) inhibition on targeted messenger RNAs (mRNAs). LncRNAs and circRNAs are involved in various neurological disorders. In this review, we summarized that lncRNAs and circRNAs participate in microglia dysfunction, astrocyte dysfunction, neuron damage, and inflammation. Thereby, lncRNAs and circRNAs can positively or negatively regulate neurological diseases, including spinal cord injury (SCI), traumatic brain injury (TBI), ischemia-reperfusion injury (IRI), stroke, neuropathic pain, epilepsy, Parkinson’s disease (PD), multiple sclerosis (MS), and Alzheimer’s disease (AD). Besides, we also found a lncRNA/circRNA-miRNA-mRNA regulatory network in microglia and astrocyte mediated neurological diseases. Through this review, we hope to cast light on the regulatory mechanisms of lncRNAs and circRNAs in microglia and astrocyte mediated neurological diseases and provide new insights for neurological disease treatment.

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Section: Spinal Cord Injurymentioning

confidence: 68%

Section: Spinal Cord Injurymentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Spinal Cord Injurymentioning

confidence: 94%

Section: Spinal Cord Injurymentioning

confidence: 99%

See 3 more Smart Citations

Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Chen

Lai

Wang

et al. 2021

Front. Mol. Neurosci.

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Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2/Keap1/Nrf2 pathway

Peng,

Hu,

Sun

et al. 2024

Phytotherapy Research

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Spinal cord injury (SCI) is a severe disabling disease that is characterized by inflammation and oxidative reactions. Tangeretin has been shown to possess significant antioxidant and anti‐inflammatory activities. The Keap1/Nrf2 pathway, downstream of the Sesn2 gene, is involved in regulating the inflammation and oxidative response. The main objective of this study was to investigate the effect of tangeretin on SCI and its possible mechanism through cell and animal models. A T9 clamp injury was used for the mouse model and the LPS‐induced stimulation of BV‐2 cells was used for the cell model. The improvement of motor function after SCI was assessed by open field, swimming, and footprint experiments. The morphological characteristics of mouse spinal cord tissue and the levels of INOS, Sesn2, TNF‐α, Keap1, Nrf2, IL‐10, and reactive oxygen species (ROS) in vivo and in vitro were measured by several methods including western blotting, qPCR, immunofluorescence, HE, and Nissl staining. In vivo data showed that tangeretin can improve motor function recovery and reduce neuron loss and injury size in mice with SCI. Simultaneously, the in vitro findings suggested that treatment of BV‐2 cells with tangeretin after LPS stimulation reduced the production of inflammatory factors and ROS, and could convert BV‐2 cells from the M1 to the M2 type. Furthermore, Sesn2 knockout suppressed Keap1/Nrf2, inflammatory factors, ROS levels, and the M1 to M2 transition. Tangeretin can alleviate the inflammation and oxidative response induced by SCI by activating the Sesn2/Keap1/Nrf2 pathway.

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The role of long noncoding ribonucleic acids in the central nervous system injury

Huang,

Wang,

Botchway

et al. 2023

Mol Cell Biochem

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The lncRNA Ftx/miR-382-5p/Nrg1 axis improves the inflammation response of microglia and spinal cord injury repair

Cited by 29 publications

References 43 publications

Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2/Keap1/Nrf2 pathway

The role of long noncoding ribonucleic acids in the central nervous system injury

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