The lncRNA ENSG00000254041.1 promotes cell invasiveness and associates with poor prognosis of pancreatic ductal adenocarcinoma

Chen, Bin; Zhang, Qiqi; Wang, Xujing; Wang, Yongkun; Cui, Jiaqu; Zhuang, Huiren; Tang, Jianying

doi:10.18632/aging.102835

Cited by 7 publications

(9 citation statements)

References 27 publications

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“…Overall survival (OS) [ 22 – 32 , 34 – 37 , 39 – 49 , 52 – 59 ], progression free survival (PFS) [ 39 , 56 ], disease specific survival (DSS) [ 33 ], and disease free survival (DFS) [ 36 ] were investigated to evaluate survival outcomes. Expression of the lncRNAs was measured by use of quantitative real-time polymerase chain reaction (qRT-PCR) using GAPDH [ 21 , 24 , 26 – 29 , 32 – 35 , 37 , 39 , 40 , 42 , 43 , 48 , 50 – 53 , 55 , 57 ], β-actin [ 23 , 29 – 31 , 45 – 47 ], RNU6B [ 25 , 38 , 41 , 44 ], U6 [ 20 , 22 , 56 ] and U7 as reference genes for endogenous normalization [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…We assessed quality of included studies using the NOS tool. Given values ranged from 4 to 8 stars based of the number of parameter that analyzed in articles: 3 study was poor quality score and awarded 4 stars [ 40 , 57 , 58 ], 5 study achieved 6 stars and medium quality [ 25 , 35 , 45 , 46 , 48 ], 13 studies gained 7 stars [ 22 , 24 , 30 , 32 , 36 – 38 , 44 , 50 , 55 , 59 – 61 ] and 18 articles awarded 8 stars with high quality [ 21 , 23 , 26 – 29 , 31 , 33 , 34 , 36 , 39 , 41 , 43 , 49 , 51 – 53 , 56 , 62 ]. The characteristics of the included studies are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

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The impact of LncRNA dysregulation on clinicopathology and survival of pancreatic cancer: a systematic review and meta-analysis (PRISMA compliant)

et al. 2021

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Purpose An increasing number of studies have reported a significant association between long non-coding RNAs (lncRNAs) dysregulation and pancreatic cancers. In the present study, we aimed to gather articles to evaluate the prognostic value of long non coding RNA in pancreatic cancer. Experimental design We systematically searched all eligible articles from databases of PubMed, Web of Science, and Scopus to meta-analysis of published articles and screen association of multiple lncRNAs expression with clinicopathology and/or survival of pancreatic cancer. The pooled hazard ratios (HRs) and their 95% confidence intervals (95% CIs) were used to analysis of overall survival, disease-free survival and progression-free survival were measured with a fixed or random effects model. Results A total of 39 articles were included in the present meta-analysis. Our results showed that dysregulation of lncRNAs were linked to overall survival (39 studies, 4736 patients HR = 0.41, 95% CI 0.25 ± 0.58, random-effects in pancreatic cancer. Moreover, altered lncRNAs were also contributed to progression-free survival (8 studies, 1180 patients HR: 1.88, 95% CI (1.35–2.62) and disease-free survival (2 studies, 285 patients, HR: 6.07, 95% CI 1.28–28.78). In addition, our findings revealed the association between dysregulated RNAs and clinicopathological features in this type of cancer. Conclusions In conclusion, dysregulated lncRNAs could be served as promising biomarkers for diagnosis and prognosis of pancreatic cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The impact of LncRNA dysregulation on clinicopathology and survival of pancreatic cancer: a systematic review and meta-analysis (PRISMA compliant)

et al. 2021

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“…35 Another lncRNA, ENSGO0000254041.1, promoted pancreatic ductal carcinoma cells invasion, which was related to the poor prognosis of patients. 36 LINC01094 was first described in renal cell carcinoma and promoted the development of clear cell renal carcinoma through the miR-224-5p/chondroitin sulfate synthase 1 (CHSY1) axis. 19 However, the function of LINC01094 in PC had not been well studied.…”

Section: Discussionmentioning

confidence: 99%

LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway

Luo

Kang

et al. 2021

Molecular Therapy - Nucleic Acids

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“…For example, in PC, lncRNA PLACT1 promoted growth and metastasis of pancreatic ductal carcinoma cells via the IκBα/E2F1 axis [29]. Another lncRNA, ENSGO0000254041.1, promoted pancreatic ductal carcinoma cells invasion, which was related to the poor prognosis of patients [30]. LINC01094 was rst described in renal cell carcinoma and promoted the development of clear cell renal carcinoma through miR-224-5p/CHSY1 axis [19].…”

Section: Discussionmentioning

confidence: 99%

LINC01094 Upregulates LIN28B Expression by Sponging miR-577 to Promote Pancreatic Cancer Proliferation and Metastasis

Luo¹,

Kang²,

Hu³

et al. 2021

Preprint

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Backgroud: The leading cause of death in pancreatic cancer (PC) patients is the progression of cancer metastasis. Long non-coding RNAs (lncRNAs) play an important role in regulating cancers, however its molecular basis in pancreatic cancer (PC) remains to be explored.Methods: In this study, bioinformatics methods are used to predict the potential pairs of lncRNAs in PC. The clinical significance of LINC01094 are determined by qRT-PCR and explored its correlation with clinicopathological parameters. The biological functions and potential mechanisms of LINC01094 in PC progression are studied in vivo and in vitro. Results: We observe that LINC01094 is markedly overexpressed in pancreatic tumors and is associated with poorer prognosis. Downregulation of LINC01094 decreases PC cell invasion and inhibits tumorigenesis and metastasis in mouse xenografts. LINC01094 acts as a sponge for miR-577, sequestering it and derepressing the expression of its endogenous target the RNA‐binding protein lin‐28 homolog B (LIN28B). Conclusions: Overall, LINC01094 upregulates LIN28B by sponging miR-577, thereby promoting PC proliferation and metastasis. This indicates that LINC01094 can be regarded as a new biomarker or therapeutic target for the treatment of PC.

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The lncRNA ENSG00000254041.1 promotes cell invasiveness and associates with poor prognosis of pancreatic ductal adenocarcinoma

Cited by 7 publications

References 27 publications

The impact of LncRNA dysregulation on clinicopathology and survival of pancreatic cancer: a systematic review and meta-analysis (PRISMA compliant)

The impact of LncRNA dysregulation on clinicopathology and survival of pancreatic cancer: a systematic review and meta-analysis (PRISMA compliant)

LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway

LINC01094 Upregulates LIN28B Expression by Sponging miR-577 to Promote Pancreatic Cancer Proliferation and Metastasis

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