The liver-kidney axis: Is serum leptin a potential link in non-alcoholic fatty liver disease-associated chronic kidney disease?

Canbakan, Mustafa; Bakkaloğlu, Oğuz Kağan; Atay, Kadri; Köroğlu, Emine; Tuncer, Mehmet Murat; Canbakan, Billur; Şentürk, Hakan

doi:10.1016/j.ajg.2023.01.001

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…A study by Manco et al in 2007 also identified a cutoff value of 14.9 ng/mL as the best predictor for NAFLD with an AUROC of 0.83 [21]. In contrast, Canbakan et al found that leptin was not an independent predictor for NAFLD [22].…”

Section: Discussionmentioning

confidence: 97%

Comparative and Predictive Significance of Serum Leptin Levels in Non-alcoholic Fatty Liver Disease

Qamar,

Fatima,

Tauseef

et al. 2024

Cureus

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BackgroundNon-alcoholic fatty liver disease (NAFLD) has emerged as the single most common chronic non-viral liver disease. The burden of the disease on healthcare-providing services has increased tremendously. Although a liver biopsy is the most authentic laboratory investigation for scoring the disease progression, it is an invasive technique. Researchers are vigorously working to find alternate markers for the scoring purpose. Despite the importance and association of leptin with metabolic syndrome and its related disorders, there have been relatively fewer studies on serum leptin and its association with NAFLD. ObjectiveThis study aimed to investigate variations in serum leptin levels between subjects with and without fibrosis in NAFLD and to assess the predictive value of serum leptin levels in NAFLD subjects. Materials and methodsThe study comprised 130 NAFLD subjects from two tertiary care hospitals in Lahore along with 86 healthy controls that were age, gender, and BMI matched with the subjects. Based on the NAFLD fibrosis score (NFS), the subjects were divided into two sub-groups, subjects with simple steatosis and those with fibrosis. Fasting serum leptin, glucose, and insulin levels were measured using enzyme-linked immunosorbent assay (ELISA). The Kruskal-Wallis test was applied to find differences between the three groups and Fisher's exact test for categorical comparison. To assess the predictive value of serum leptin for steatosis and fibrosis in NAFLD subjects, receiver operation characteristic (ROC) curve analysis was implemented. ResultsThe difference in serum leptin level was statistically highly significant (p-value <0.001), with leptin levels of 10 (17.1) ng/mL among controls, 20.5 (21) ng/mL in simple steatosis, and 21 (28.6) ng/mL in fibrosis. The area under the ROC curve was 0.67 and 0.52 for steatosis and fibrosis, respectively. The cut-off value of 12.2 ng/mL showed 70% sensitivity and 50% specificity for steatosis, while at a threshold of 18 ng/mL, leptin demonstrated 40% sensitivity and specificity for fibrosis. ConclusionIn conclusion, this study found that serum leptin levels are higher in NAFLD subjects compared to healthy controls, and it is a good independent predictor for the detection of liver steatosis.

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Section: Discussionmentioning

confidence: 97%