The Liver in Pediatric Gastrointestinal Disease

Vo, Hanh D.; Xu, Jiele; Rabinowitz, Simon S.; Fisher, Stanley E.; Schwarz, Steven M.

doi:10.1097/mpg.0000000000000444

Cited by 15 publications

(19 citation statements)

References 208 publications

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“…A recent study carried out in the United Kingdom evaluating individuals with class III obesity in preoperative bariatric surgery [54] showed a 90% percentage of serum vitamin D deficiency, assessed in the form of 25(OH)D in the sample studied, data similar to our findings. Among the indicators of hepatocellular damage most widely used in the literature are GGT and AP transaminases [55], but in this study mean levels of ALT, AST, and AP among individuals with hepatic steatosis and steatohepatitis showed no significant differences. Although many studies have reported an increase in indicators of liver function and damage in individuals with various degrees of NAFLD [56, 57], these enzymes generally are normal in over 78% of individuals [58].…”

Section: Discussioncontrasting

confidence: 58%

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

Cordeiro

Pereira

Saboya³

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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Aim To evaluate the relationship of nonalcoholic fatty liver disease (NAFLD) with nutritional status of vitamin D in extreme obesity. Methods Descriptive cross-sectional study in individuals with class III obesity (BMI ≥ 40 kg/m2), aged ≥ 20 years to < 60 years. Data were obtained for weight, height, waist circumference (WC), and serum 25-hydroxyvitamin D (25(OH)D) levels. Vitamin D analysis was performed by high performance liquid chromatography (HPLC) and the cutoff points used for its classification were < 20 ng/mL for deficiency and 20–29.9 ng/ml for insufficiency. NAFLD gradation was conducted through histological evaluation by liver biopsy. Results The sample is comprised of 50 individuals (86% female). BMI and average weight were 44.1 ± 3.8 kg/m2 and 121.4 ± 21.4 kg, respectively. Sample distribution according to serum 25(OH)D levels showed 42% of deficiency and 48% of insufficiency. The diagnosis of NAFLD was confirmed in 100% of the individuals, of which 70% had steatosis and 30% had steatohepatitis. The highest percentage of 25(OH)D insufficiency was seen in individuals with steatosis (66%/n = 21) and steatohepatitis (93%/n = 16). All individuals with steatohepatitis presented VDD (p < 0.01). Conclusion The results of this study showed high prevalence of serum 25(OH)D inadequacy in individuals with class III obesity, which worsens as the stage of liver disease progresses.

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Section: Discussioncontrasting

confidence: 58%

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

Cordeiro

Pereira

Saboya³

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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“…Кроме того, была отмечена перекрестная чувствительность к антибактериальным препаратам группы бета-лактамов: гепатотоксичность последовательно возникала после применения эртапенема, цефтриаксона, препарата амоксициллин+клавулановая кислота, что соответствует данным H. D. Vo с соавт. [12].…”

Section: Discussionunclassified

A Case of Multiple Antibiotic-Associated Hepatotoxicity in an Infant

Постников

Теплова

Nikolaev

et al. 2019

Bezopasnost' i risk farmakoterapii

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Drug induced liver injury is one of the most frequent reasons for stopping treatment and the main cause of the onset and progression of acute liver failure, requiring liver transplantation. In children antibacterial drugs are on the first place in terms of hepatotoxicity, and the hepatocellular type is the most common type of liver damage. Often there is crosssensitivity within the same group of antibiotics, for example, beta-lactams. The aim: to analyze the causes of drug hepatotoxicity in the infant child while taking antibacterial agents. The article presents a clinical case of multiple hepatotoxicity caused by antibacterial agents such as beta-lactams, fluoroquinolones, sulfanilamides in one infant child, which suggests its genetic basis. It was shown that during therapy it is important to take into account the risk factors for hepatotoxicity (age, concomitant pathology, potential drug interactions with simultaneous use) and regularly evaluate the patient’s condition taking into account possible liver damage (including laboratory tests).

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“…Among the hepatocellular damage markers mostly used in the literature are the transaminases, GGT, and AP [ 22 ]. In this study, the ALT, AST, and AP mean levels among individuals with hepatic steatosis and steatohepatitis showed no significant differences.…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease Relationship with Metabolic Syndrome in Class III Obesity Individuals

Cordeiro

Pereira

Saboya

et al. 2015

BioMed Research International

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Introduction. Obesity is represented mainly by abdominal obesity and insulin resistance (IR), both present in most individuals diagnosed with metabolic syndrome (MS). IR is the key risk factor in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Objective. To relate NAFLD to MS in class III obese individuals. Methodology. A descriptive cross-sectional study with class III obese individuals, aged ≥ 20–60 years. Blood pressure measurement, weight, height, body mass index (BMI), waist circumference (WC) and blood glucose, insulin, high-density lipoprotein cholesterol (HDL-c), and triglycerides data were obtained. HOMA-IR (homeostatic model assessment insulin resistance) calculation was carried out with a cutoff value of 2.71 for IR evaluation. The diagnosis of NAFLD was performed by liver biopsy and the diagnosis of MS was performed in accordance with the National Cholesterol Education Program/Adult Treatment Panel III (NCEPATP III). Results. Of the 50 individuals evaluated, 86% were women and BMI means were 45.4 ± 3.6 Kg/m2. The overall individuals had NAFLD, 70% steatosis, and 30% steatohepatitis. The diagnosis of MS occurred in 56% but showed no significant association with NAFLD (P = 0.254). Triglycerides (178 ± 65.5 mg/dL) and insulin (28.2 ± 22.6 mcU/mL) mean values were significantly higher in steatohepatitis (P = 0.002 and P = 0.042, resp.) compared to individuals with steatosis. IR was confirmed in 76% and showed a relationship with NAFLD severity. Conclusion. NAFLD was not related to MS; however, MS components, evaluated in isolation, as well as IR, were related to the presence and severity of NAFLD.

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The Liver in Pediatric Gastrointestinal Disease

Cited by 15 publications

References 208 publications

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

A Case of Multiple Antibiotic-Associated Hepatotoxicity in an Infant

Nonalcoholic Fatty Liver Disease Relationship with Metabolic Syndrome in Class III Obesity Individuals

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