The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression

Baba, Hayato; Tsuneyama, Koichi; Yazaki, Megumi; Nagata, Kohei; Mizutani, Takashi; Tsuda, Tatsuhiro; Nomoto, Kazuhiro; Hayashi, S.; Miwa, Satoshi; Nakajima, Takahiko; Nakanishi, Yuko; Aoshima, Keiko; Imura, Johji

doi:10.1038/modpathol.2013.62

Cited by 129 publications

(60 citation statements)

References 30 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our analysis also showed that Cd concentration tended to decrease as the Cd-induced kidney injury advanced in severity. We previously reported the same tendency also in the liver of IID patients (Baba et al, 2013). Our findings strongly support the conventional idea.…”

Section: Discussionsupporting

confidence: 81%

Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease

et al. 2014

Self Cite

View full text Add to dashboard Cite

-Background & Aims Cadmium (Cd) is a widespread environmental contaminant that causes both renal tubulopathy and osteomalacia. Osteomalacia is thought to be a result of renal tubulopathy, but there are few studies about the histopathological relationship between the two pathoses. Therefore, in the present study, we examined specimens from cases of itai-itai disease (IID), the most severe form of chronic cadmium poisoning, to evaluate the relationship between them. Methods We analyzed kidney and bone specimens of 61 IID cases and the data regarding Cd concentration in kidney and bone. Tubulopathy was graded on the basis of a three-step scale (mild, moderate, and severe) using the following three items: the degree of proximal tubular defluxion, thickness of renal cortex, and weight of the kidney. Osteomalacia was evaluated using the relative osteoid volume (ROV). Results There were 15 cases of mild, 19 cases of moderate, and 27 cases of severe tubulopathy. The average ROV was 24.9 ± 2.0%. ROV tended to increase as tubulopathy advanced in severity, and ROV was significantly higher in cases with severe tubulopathy than those with mild or moderate tubulopathy. ROV had a negative correlation with Cd concentration in the kidney but no correlation with that in the bone. Conclusions Our results suggest that the development of osteomalacia was related to the development of tubulopathy.

show abstract

Section: Discussionsupporting

confidence: 81%

Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…We hypothesize that cadmium is released from tissues. Liver is well-known to accumulate cadmium; lower levels of cadmium in muscle, making up a larger fraction of total body mass, may also contribute(14, 30, 41, 42). …”

Section: Discussionmentioning

confidence: 99%

Cadmium blood and urine concentrations as measures of exposure: NHANES 1999–2010

Adams

Newcomb

2013

J Expo Sci Environ Epidemiol

160

104

View full text Add to dashboard Cite

Exposure to cadmium, a heavy metal present in cigarettes, can be assessed in both urine and blood. Few studies have compared the properties of concurrent measurements of urine cadmium (uCd) and blood cadmium (bCd) in relation to the duration and timing of a known exposure. In this study, bCd and uCd were modeled with data from the National Health and Nutrition Examination Survey (1999–2010). Adjusted geometric mean bCd and uCd were estimated from regression results. Each 1% higher geometric mean uCd was associated with 0.50% (95% CI: 0.47%–0.54%; R2=0.30) higher bCd. In male never-smokers, bCd was 69% (59%–81%) and uCd was 200%(166%–234%) higher at age ≥70y versus 20–29y. Ten pack-years (py) of smoking were associated with 13.7%(10.0%–17.4%) higher bCd and 16.8% (12.6%–21.1%) higher uCd in male smokers. The first year after smoking cessation was associated with 53% (48%–58%) lower bCd and 23%(14%–33%) lower uCd in representative males age 55y with 20py smoking. Smoking in the previous 5 days was associated with 55%(40%–71%) higher bCd and 7%(−3%–18%) higher uCd. Results were similar for women. uCd mainly measures long-term exposure and bCd recent exposure, but with noticeable overlap. Epidemiological studies should base the choice of uCd or bCd on the timing of cadmium exposure relevant to the disease under study.

show abstract

“…Furthermore, Cd can also produce toxicity to other systems of human body, and even induce cell distortion and cancerization (Wu, 2015). One of the most famous accidents was the “Itai-Itai Disease” that occurred in Toyama Prefecture of Japan in 1960s (Baba et al, 2013). Several events of human Cd poisoning resulting from soil Cd pollution have subsequently been reported around the world (Sterckeman et al, 2000; Du et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cadmium Accumulation Characteristics in Turnip Landraces from China and Assessment of Their Phytoremediation Potential for Contaminated Soils

Zhang

Yang

et al. 2016

Front. Plant Sci.

View full text Add to dashboard Cite

Heavy metal (HM) pollution is a global environmental problem that threatens ecosystem and human health. Cadmium (Cd) pollution is the most prominent HM pollution type because of its high toxicity, strong migration, and the large polluted area globally. Phytoremediation of contaminated soil is frequently practiced because of its cost-effectiveness and operability and because it has no associated secondary pollution. High-accumulation plants, including those identified as hyperaccumulators, play an important role in phytoremediation. Therefore, screening of plants to identify hyperaccumulators is important for continued phytoremediation. In the present study, we investigated the Cd tolerance and accumulation capabilities of 18 turnip landraces from China under a soil experiment with known Cd level. The results indicated that turnip has a high capacity for Cd accumulation. Furthermore, significant differences in Cd tolerance and accumulation characteristics were found among different landraces when they grew at 50 mg kg-1 (dry weight) Cd concentration. Among the studied landraces, five turnip landraces met the requirements of Cd hyperaccumulators and three landraces were identified as potential candidates. However, the total Cd content accumulated by individual plant of different turnip landraces was dependent on both the Cd accumulation capacity and plant biomass. Compared with some reported Cd hyperaccumulators, turnip not only shows a high Cd-accumulation capacity but also has rapid growth and a wide distribution area. These advantages indicate that turnip may have considerable potential for phytoremediation of Cd-contaminated soil. Furthermore, the study also indicates that it is not advisable to consume turnip cultivated in an environment that exceeds safe Cd levels.

show abstract

The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression

Cited by 129 publications

References 30 publications

Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease

Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease

Cadmium blood and urine concentrations as measures of exposure: NHANES 1999–2010

Cadmium Accumulation Characteristics in Turnip Landraces from China and Assessment of Their Phytoremediation Potential for Contaminated Soils

Contact Info

Product

Resources

About