The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver

Abstract

The present study offers data that are useful for the diagnosis and treatment of patients with collagen diseases and liver abnormalities.

An autopsy case showing massive fibrinoid necrosis of the portal tracts of the liver with cholangiographic findings similar to those of primary sclerosing cholangitis

“…In our case laboratory findings or symptoms were not suggestive of any autoimmune disease or malignant hypertension. The liver pathology was also quite different from that of reported cases with collagen diseases [8][9][10] . On a search of the literature using key words such as fibrinoid necrosis, vasculitis, we could not find any case similar to ours.…”

CD8-positive T Cell-induced Liver Damage was Found in a Patient with Polymyositis

“…On the other hand, a variety of histological findings of liver including non-specific reactive hepatitis are found in patients with collagen disease (2,7). In the present case, liver histology showed mild perivascular infiltration by CD8 T cells, which were uncommon in AIH.…”

Improvement of Rheumatoid Arthritis and Autoimmune Hepatitis in a Patient Treated with the Tumor Necrosis Factor Inhibitor, Etanercept

“…Therefore, histology obtained from liver biopsy was important in the present case (13)(14)(15). The histology of hepatic lesions due to SjS or RA has been reported as non-specific inflammation with infiltration of mononuclear cells and with fatty change (13,16,17). SjS is also known to be associated with primary billiary cirrhosis (16,18).…”