The liver fluke<i>Opisthorchis felineus</i>as a group III or group I carcinogen

Pakharukova, Mariya Yurievna; Costa, José Manuel Correia da; Mordvinov, Viatcheslav A.

doi:10.1051/fopen/2019016

Cited by 12 publications

(9 citation statements)

References 33 publications

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“…It is important to note that the main reservoir of O . felineus in Western Siberia is wild fish-eating animals, such as feral carnivores 1 , 2 . It is believed that the zoonotic cycle of O .…”

Section: Introductionmentioning

confidence: 99%

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A comparative study of Helicobacter pylori infection in hamsters experimentally infected with liver flukes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis

Pakharukova

Zaparina

Hong

et al. 2021

Sci Rep

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Helicobacter pylori causes a wide range of human diseases including cancer. Carcinogenic foodborne trematodes Opisthorchis viverrini, Clonorchis sinensis, and O. felineus might promote transmission and spread of H. pylori infection in the definitive mammalian host, which in turn might contribute to the liver fluke-associated malignancy. Our objectives were to find out whether liver flukes O. felineus, O. viverrini, and C. sinensis are carriers of Helicobacter pylori and to determine whether H. pylori is present in feces, bile, and stomach samples from the experimentally infected hamsters. We found that liver flukes are not reservoirs of H. pylori. Nevertheless, the prevalence of H. pylori and the H. pylori ureA gene copy number were significantly elevated after the infection. Overall, although the liver flukes O. felineus, C. sinensis, and O. viverrini are not reservoirs of H. pylori, the infection with the liver flukes significantly modifies the biliary and gut microbiota by increasing H. pylori abundance. This may be a feature of any liver fluke pathogenesis that have not previously been taken into account. Our findings appear to be novel in terms of comparative assessment of the host microbiota and Helicobacter abundance during epidemiologically important liver fluke infections.

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Section: Introductionmentioning

confidence: 99%

“…viverrini and C . sinensis 2 , 5 , and this species is recognized as a potentially dangerous agent (Group 2B) 4 .…”

Section: Introductionmentioning

confidence: 99%

A comparative study of Helicobacter pylori infection in hamsters experimentally infected with liver flukes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis

Pakharukova

Zaparina

Hong

et al. 2021

Sci Rep

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“…Even though the carcinogenesis pathology caused by parasitic infection may be driven by a variety of events known as chronic inflammatory infectious processes, helminthiases related to malignancy remain mainly unknown. Additional pathways involve genomic instability, induction of invasion, angiogenesis, and cancer metastases, deregulation of tumor suppressor genes, prolonged cell growth, cell death prevention, energy metabolism regulation, and immune evasion ( Machicado & Marcos, 2016 ; Pakharukova et al ., 2019 ; Fedorova et al ., 2020 ). The three liver trematode species differ in how they become carcinogens, but there have been no comparative research studies, thus the information that is currently accessible is not sufficiently clear.…”

Section: The Incidence Of Cholangiocarcinoma Caused By Liver Trematodesmentioning

confidence: 99%

Fish and Food-Fatale: Food-borne Trematode Opisthorchis viverrini and Cholangiocarcinoma

Tan,

Machrumnizar

2023

Helminthologia

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Summary Neglected Tropical Diseases (NTDs) are a group of communicable diseases with a long history with human beings. NTDs are the proxy of poverty since they affect those in low-income and extreme-poverty populations, as those populations lack access to proper health care, clean water, sanitary conditions, and hygiene. NTDs create losses for a nation that come from the health and the economic sectors as well since the costs of diagnosis, prevention, and treatment strain the national purse strings. One of the 20 different forms of NTDs on the list is food-borne trematodes, comprises of Fasciola, Paragonimus, Clonorchis, and Opisthorchis. Currently, it is estimated that food-borne trematodes can cause a devastating effect on mortality and morbidity. All of them are zoonotic, as humans become infected by ingestion of a second intermediate host, such as freshwater snails, fish, or water vegetables. Opisthorchis viverrini, one of the food-borne trematodes that can be found mostly in South East Asia regions, especially in the Mekong basin, is regarded as a group 1 carcinogen leading to cholangiocarcinoma (CCA). This study aims to present the updated review of Opisthorchis viverrini and CCA.

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“…Schistosoma japonicum (Group 2b) and Opisthorchis felineus (Group 3) are not classified as definitive biological carcinogens ( Vennervald and Polman, 2009 ; IARC, 2012 ). Yet, recent findings have indicated that infection with the European liver fluke O. felineus may eventually lead to cholangiocarcinoma (CCA) ( Gouveia et al., 2017 ; Pakharukova et al., 2019 ; Fedorova et al., 2020 ) and that infection with S. japonicum may be a risk factor for colorectal cancer ( Wu et al., 2020 ). Curiously, chronic infections with related trematodes, the blood flukes Schistosoma mansoni and the liver fluke Fasciola hepatica have not been classified as biological carcinogens.…”

Section: Helminth Infections and Cancermentioning

confidence: 99%

Control Strategies for Carcinogenic-Associated Helminthiases: An Integrated Overview

Costa

Gouveia

Rinaldi

et al. 2021

Front. Cell. Infect. Microbiol.

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Helminthiases are extremely prevalent in the developing world. In addition, the chronic infection with some parasitic worms are classified as carcinogenic. Therefore, it is utmost importance to understand the parasite-host interactions, the mechanisms underlay carcinogenesis and how they could be counteracted. This knowledge may ultimately guide novel control strategies that include chemotherapy-based approaches targeting these pathogens and associated pathologies caused by their infections. Little is known on how some helminthiases are associated with cancer; however, it has been hypothesized that chemical carcinogenesis may be involved in the process. Here, we summarize the current knowledge on chemical carcinogenesis associated with helminthiases, along with available therapeutic options and potential therapeutic alternatives including chemotherapy and/or immunotherapy. Ideally, the treatment of the carcinogenic helminthiases should target both the parasite and associated pathologies. The success of any chemotherapeutic regimen often depends on the host immune response during the infection and nutritional status among other factors. The close association between chemotherapy and cell-mediated immunity suggests that a dual therapeutic approach would be advantageous. In addition, there is a pressing need for complementary drugs that antagonize the carcinogenesis process associated with the helminth infections.

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The liver flukeOpisthorchis felineusas a group III or group I carcinogen

Cited by 12 publications

References 33 publications

A comparative study of Helicobacter pylori infection in hamsters experimentally infected with liver flukes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis

A comparative study of Helicobacter pylori infection in hamsters experimentally infected with liver flukes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis

Fish and Food-Fatale: Food-borne Trematode Opisthorchis viverrini and Cholangiocarcinoma

Control Strategies for Carcinogenic-Associated Helminthiases: An Integrated Overview

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