The liver as a nursery for leukocytes

Mafra, Kassiana; Nakagaki, Brenda Naemi; Oliveira, Hortência Maciel Castro; Rezende, Rafael M.; Antunes, Maísa Mota; Menezes, Gustavo B.

doi:10.1002/jlb.mr1118-455r

Cited by 5 publications

(3 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These lymphocytes dwelling within the liver are involved in immune surveillance, immune regulation and maintenance of hepatic homeostasis. In addition, the liver‐resident macrophages and DCs, comprise a significant number of non‐hepatocytes which may act as a hepatic immune sentinel to remove or alert the immune system about the presence of harmful invaders 262,263 . Recent research has demonstrated that kidney and spleen also exhibited many tissue‐resident features.…”

Section: The Role Of Microalgae In Aquaculture Productionmentioning

confidence: 99%

“…In addition, the liver-resident macrophages and DCs, comprise a significant number of non-hepatocytes which may act as a hepatic immune sentinel to remove or alert the immune system about the presence of harmful invaders. 262,263 Recent research has demonstrated that kidney and spleen also exhibited many tissue-resident features. They contain a large number of immune cells including resident macrophages, neutrophils, B and T lymphocytes and NK cells that inhibited the foreign pathogens.…”

Section: Immunity and Disease Resistance Of Fish And Shellfishmentioning

confidence: 99%

See 1 more Smart Citation

Expanded utilisation of microalgae in global aquafeeds

Siddik

Sørensen

Islam

et al. 2023

Reviews in Aquaculture

View full text Add to dashboard Cite

Utilising novel ingredients in aquafeeds is necessary for the continued expansion and intensification of aquaculture production. Microalgae are utilised widely in aquaculture for a variety of purposes; as live feed for fish and shellfish larvae and juveniles, for the production of algae‐based meals and oils to replace marine derived raw materials in aquafeeds, and for the production of astaxanthin, the carotenoid that gives salmon flesh its characteristic reddish colour. Notably, long‐chain polyunsaturated fatty acids, amino acids, proteins, fibres, antioxidant pigments, vitamins and minerals are among the compounds in microalgae with great biological value. A growing collection of experimental data has demonstrated that these substances are crucial for increasing larval survival and enhancing the growth and well‐being of fish and shellfish. In this review, the processing of microalgae utilised as aquafeed ingredient, the health promoting compounds in microalgae and their role in growth, immunity and disease resistance of fish and shellfish are described and discussed. Simultaneously, major hurdles in the commercial use of microalgae in aquafeed, and future research and development perspectives are all critically discussed.

show abstract

Section: The Role Of Microalgae In Aquaculture Productionmentioning

confidence: 99%

Section: Immunity and Disease Resistance Of Fish And Shellfishmentioning

confidence: 99%

Expanded utilisation of microalgae in global aquafeeds

Siddik

Sørensen

Islam

et al. 2023

Reviews in Aquaculture

View full text Add to dashboard Cite

show abstract

“…The liver has a unique characteristic morphologic organization, cell composition, and functions. Kupffer cells, the liver-resident macrophages, and DCs, comprise a significant number of the non-hepatocytes and act as a hepatic immune sentinel to remove or alert the immune system about the presence of harmful pathogens (8, 9). In terms of its lymphocyte composition, the lymphocytes in the liver are highly distinct from those in blood and lymphoid organs.…”

Section: Introductionmentioning

confidence: 99%

The Roles of Liver-Resident Lymphocytes in Liver Diseases

Wang

Zhang

2019

Front. Immunol.

View full text Add to dashboard Cite

Tissue-resident lymphocytes usually reside in barrier sites and are involved in innate and adaptive immunity. In recent years, many studies have shown that multiple types of lymphocytes are resident in the liver, including memory CD8 + T (T RM ) cells; “unconventional” T cells, such as invariant natural killer T (iNKT) cells, mucosal associated invariant T (MAIT) cells, and γδT cells; innate lymphoid cells (ILCs) such as natural killer (NK) cells and other ILCs. Although diverse types of tissue-resident lymphocytes share similar phenotypes, functional properties, and transcriptional regulation, the unique microenvironment of the liver can reshape their phenotypic and functional characteristics. Liver-resident lymphocytes serve as sentinels and perform immunosurveillance in response to infection and non-infectious insults, and are involved in the maintenance of liver homeostasis. Under the pathological conditions, distinct liver-resident lymphocytes exert protective or pathological effects in the process of various liver diseases. In this review, we highlight the unique properties of liver-resident lymphocytes, and discuss their functional characteristics in different liver diseases.

show abstract

Single-cell transcriptome profiling reveals neutrophil heterogeneity and orchestrated maturation during homeostasis and bacterial infection

Xie

Shi

et al. 2019

Preprint

View full text Add to dashboard Cite

SummaryThe full neutrophil heterogeneity and differentiation landscape remains incompletely characterized. Here we profiled >25,000 differentiating and mature mouse neutrophils using single-cell RNA sequencing to provide a comprehensive transcriptional landscape of neutrophil maturation, function, and fate decision in their steady state and during bacterial infection. Eight neutrophil populations were defined by distinct molecular signatures. The three mature peripheral blood neutrophil subsets arise from distinct maturing bone marrow neutrophil subsets. Driven by both known and uncharacterized transcription factors, neutrophils gradually acquire microbicidal capability as they traverse the transcriptional landscape, representing an evolved mechanism for fine-tuned regulation of an effective but balanced neutrophil response. Bacterial infection reprograms the genetic architecture of neutrophil populations, alters dynamic transition between each subpopulation, and primes neutrophils for augmented functionality without affecting overall heterogeneity. In summary, these data establish a reference model and general framework for studying neutrophil-related disease mechanisms, biomarkers, and therapeutic targets at single-cell resolution.Graphical AbstractHighlightsA comprehensive single-cell resolution transcriptional landscape of mouse neutrophil maturation and fate decision under steady-state and bacterial infection conditions.The pathogen clearance machinery in neutrophils is continuously and gradually built during neutrophil differentiation, maturation, and aging, driven by both known and uncharacterized transcription factors.The three mature neutrophil subsets in peripheral blood, including a novel ISG-expressing subset, are derived from distinct bone marrow neutrophil precursors.Bacterial infection reprograms the genetic architecture of neutrophil populations, alters dynamic transition between each subpopulation, and primes neutrophils for augmented functionality without affecting overall neutrophil heterogeneity.Bacterial infection-induced emergency granulopoiesis is mediated by augmented proliferation of early stage neutrophil progenitors and accelerated post-mitotic maturation.

show abstract

The liver as a nursery for leukocytes

Cited by 5 publications

References 85 publications

Expanded utilisation of microalgae in global aquafeeds

Expanded utilisation of microalgae in global aquafeeds

The Roles of Liver-Resident Lymphocytes in Liver Diseases

Single-cell transcriptome profiling reveals neutrophil heterogeneity and orchestrated maturation during homeostasis and bacterial infection

Contact Info

Product

Resources

About