The liver and lovastatin

Tolman, Keith G.

doi:10.1016/s1062-1458(02)00916-9

Cited by 50 publications

(76 citation statements)

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“…Statins are rarely responsible for acute liver failure (ALF) -e.g. the use of lovastatin was reported to be related with ALF in 1/1.14 million patient-treatment years, what is similar to the rate of idiopathic ALF [114,115]. Statin treatment might be useful in significantly reducing the risk of hepatocellular carcinoma (HCC) (even by 28%) [116].…”

Section: Hepatitis B (Hbv) and C Virus (Hcv) Liver Diseasementioning

confidence: 91%

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Banach

Rizzo²,

Tóth

et al. 2015

Expert Opinion on Drug Safety

181

204

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Section: Hepatitis B (Hbv) and C Virus (Hcv) Liver Diseasementioning

confidence: 91%

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Banach

Rizzo²,

Tóth

et al. 2015

Expert Opinion on Drug Safety

181

204

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“…Statin therapy, like all cholesterollowering therapy including bariatric surgery (117,118), causes minor but transient elevations in liver enzymes (119). However, the liver adapts with continuing therapy, and there are no long-term consequences of these abnormalities.…”

Section: Pharmacologic Therapymentioning

confidence: 99%

“…However, the liver adapts with continuing therapy, and there are no long-term consequences of these abnormalities. Severe liver damage and liver failure are very rare (119). Paradoxically, statins are currently used to treat NAFLD (120,121), and recent studies suggest that statins are hepatoprotective in patients with HCV (122).…”

Section: Pharmacologic Therapymentioning

confidence: 99%

Spectrum of Liver Disease in Type 2 Diabetes and Management of Patients With Diabetes and Liver Disease

et al. 2007

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“…2,141,142 Monitoring the liver tests at the beginning and during statin therapy is under debate. 143,144 Autoimmune-like hepatitis has been reported in several cases and may be correlated with HLA-DR3, DR4, or DR5.…”

Section: Lipid-lowering Agentsmentioning

confidence: 99%

Drug-Induced Liver Injury

Hamilton

Collins‐Yoder

Collins

2016

AACN Advanced Critical Care

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Drug-induced liver injury (DILI) is common and nearly all classes of medications can cause liver disease. Most cases of DILI are benign, and improve after drug withdrawal. It is important to recognize and remove the offending agent as quickly as possible to prevent the progression to chronic liver disease and/or acute liver failure. There are no definite risk factors for DILI, but preexisting liver disease and genetic susceptibility may predispose certain individuals. Although most patients have clinical symptoms that are identical to other liver diseases, some patients may present with symptoms of systemic hypersensitivity. Treatment of drug and herbal-induced liver injury consists of rapid drug discontinuation and supportive care targeted to alleviate unwanted symptoms. KeywordsDrug-induced liver injury (DILI); drug-induced hepatitis; drug-induced cholestasis; acetaminophen; vanishing bile duct syndrome; herbal toxicity Adverse drug reactions are an important cause of liver injury that may require discontinuation of the offending agent, hospitalization, or even liver transplantation. 1 Indeed, drug-induced hepatotoxicity is the most frequent cause of acute liver failure in US. 2 Because the liver is responsible for concentrating and metabolizing a majority of medications, it is a prime target for medication-induced damage. Among hepatotoxic drugs, acetaminophen (paracetamol) is the most often studied. However, a broad range of different pharmacological agents can induce liver damage, including anesthetics, anticancer drugs, antibiotics, antituberculosis agents, antiretrovirals, and cardiac medications. In addition, a plethora of traditional medical therapies and herbal remedies may also be hepatotoxic.Depending on the duration of injury and the histological location of damage, drug-induced liver injury (DILI) is categorized as acute or chronic, and either as hepatitis, cholestatic, or a mixed pattern of injury. The hepatitis pattern is characterized by hepatocyte necrosis and is associated with a poor prognosis. There are three types of acute cholestatic drug-induced injury: bland cholestasis is the result of abnormal biliary secretion, and is not accompanied by significant hepatocellular damage; cholestatic hepatitis (mixed type) refers to cholestasis with concomitant hepatic parenchymal damage; and the third form of acute cholestasis is

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The liver and lovastatin

Cited by 50 publications

References 0 publications

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Spectrum of Liver Disease in Type 2 Diabetes and Management of Patients With Diabetes and Liver Disease

Drug-Induced Liver Injury

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