The live birth in a woman with resistant ovary syndrome after in vitro oocyte maturation and preimplantation genetic testing for aneuploidy

Kornilov, N.N.; Pavlova, M. N.; Yakovlev, Pavel P.

doi:10.1007/s10815-021-02085-5

Cited by 10 publications

(3 citation statements)

References 24 publications

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“…Studies have reported that the obstetric, perinatal, and neonatal outcomes and development of children conceived from IVM cycles seem similar to spontaneous conceptions or IVF treatment ( 12 , 44 , 45 ). Additionally, some studies have proved that an embryo from IVM oocytes could obtain a normal karyotype ( 46 , 47 ). We should consider that data on IVM children are limited in our study, both in numbers and duration of follow-up.…”

Section: Discussionmentioning

confidence: 99%

Rescue in vitro maturation may increase the pregnancy outcomes among women undergoing intracytoplasmic sperm injection

et al. 2022

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IntroductionTo investigate whether rescue in vitro maturation (R-IVM) improves the reproductive outcomes among women undergoing intracytoplasmic sperm injection (ICSI) after one oocyte retrieved cycle.MethodsBetween January 2019 and December 2020, 2602 women who underwent ICSI in the Reproductive Medicine Center of Tongji Hospital, Wuhan, China, were included in our retrospective cohort study. There were 2112 women undergoing only ICSI and 490 women with R-IVM followed by ICSI. The intermediate reproductive outcomes and pregnancy outcomes were assessed, including the number of normally fertilized embryos, number of cleaved embryos, number of good-quality embryos, number of day-3 available embryos, number of embryos cultured past day-3, number of blastocysts, number of available blastocysts, biochemical pregnancy, miscarriage, clinical pregnancy and live birth. The perinatal outcomes were also assessed, including preterm birth and birth weight. The abovementioned outcomes were also calculated for in vivo matured and R-IVM oocytes separately in women undergoing ICSI with R-IVM group.Result(s)Compared with the women who underwent only ICSI, those who underwent ICSI with R-IVM had higher numbers of MII oocytes, normally fertilized embryos, cleaved embryos, day-3 available embryos, embryos cultured past day-3, and higher oocyte maturation rate, available embryo rate than women undergoing only ICSI. Additionally, we found that women undergoing ICSI with R-IVM had an increased chance of clinical pregnancy (adjusted OR=1.50, 95% CI: 1.17–1.93) and cumulative live birth (adjusted OR=1.35, 95% CI: 1.07–1.71). After propensity score matching (PSM), the cumulative live birth rate was 60.1% for women undergoing ICSI with R-IVM versus 54.9% for women undergoing only ICSI (OR=1.24, 95% CI: 0.94–1.63). The reproductive outcomes were also significantly different when calculated for in vivo matured and R-IVM oocytes separately in women undergoing ICSI with R-IVM group. All live births from R-IVM embryos were healthy and without malformations or complications.ConclusionR-IVM may improve the reproductive outcomes of women undergoing ICSI. It may also provide a reference for the safety of R-IVM. This study maybe support a routine application of R-IVM among patients who intend to undergo ICSI.

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Section: Discussionmentioning

confidence: 99%

Rescue in vitro maturation may increase the pregnancy outcomes among women undergoing intracytoplasmic sperm injection

et al. 2022

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“…Indications for IVM include cases of ROS with impaired oocyte maturation. Since 2013, several cases of ROS in women successfully conceiving following IVM have been reported clinically (62,(81)(82)(83)(84)(85)(86)(87). Galvao et al (83) reported that nine patients with ROS underwent 24 IVM cycles and found that the live birth rate was 16.7% per started cycle and 33.3% per patient.…”

Section: In Vitro Maturation Of Oocytesmentioning

confidence: 99%

Resistant ovary syndrome: Pathogenesis and management strategies

Shen

Lei

2022

Front. Med.

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Resistant ovary syndrome (ROS) is a rare and difficult gynecological endocrine disorder that poses a serious risk to women’s reproductive health. The clinical features are normal sex characteristics, regular female karyotype, and usual ovarian reserve, but elevated endogenous gonadotropin levels and low estrogen levels with primary or secondary amenorrhea. Although there have been many case reports of the disease over the past 50 years, the pathogenesis of the disease is still poorly understood, and there are still no effective clinical management strategies. In this review, we have collected all the current reports on ROS and summarized the pathogenesis and treatment strategies for this disease, intending to provide some clinical references for the management and treatment of this group of patients and provide the foothold for future studies.

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“…[1][2][3][4] Due to the low incidence of ROS, few large sample studies have been conducted involving successful cases. Pregnancies resulting from the patient's own oocytes have mainly been achieved through hormone replacement therapy (HRT) [5][6][7][8][9][10][11][12] or in vitro maturation (IVM), [13][14][15][16][17][18][19] and a handful of conventional in vitro fertilization (c-IVF) after controlled ovarian stimulation (COS). [17,[20][21][22] Therefore, ROS patients who are unable to produce mature oocytes may have to resort to donor oocytes.…”

Section: Introductionmentioning

confidence: 99%

Resistant ovary syndrome: Two case reports and a literature review of effective controlled ovarian stimulation in IVF

Zhao,

Zheng,

et al. 2024

Medicine

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Introduction: Resistant ovary syndrome (ROS) represents a rare reproductive endocrine disorder that is predominantly associated with infertility, characterized by heightened endogenous gonadotropin levels in the presence of a normal ovarian reserve. Patients with ROS typically exhibit a poor response to exogenous gonadotropins during controlled ovarian stimulation (COS). Due to the absence of a universally accepted effective COS protocol, this study aims to contribute to the existing body of literature by detailing 2 successful pregnancies achieved through conventional in vitro fertilization (c-IVF) in patients with ROS, and through retrospective analysis, seeks to elucidate the factors contributing to the successful ovarian stimulation in these cases, with the ultimate goal of establishing clinical guidelines for ROS management. Patient Concerns: The central challenge addressed in this study pertains to the effective induction of oocyte maturation during c-IVF COS in ROS patients. Diagnosis: The study focuses on 2 infertile women diagnosed with ROS who sought to conceive via c-IVF. Interventions: The patients were subjected to a COS protocol involving pituitary downregulation followed by ovarian stimulation using recombinant follicle-stimulating hormone (r-FSH) and human menopausal gonadotropin (HMG), preceded by 3 cycles of hormone replacement therapy (HRT) pretreatment. Outcomes: The proposed protocol elicited a favorable ovarian response, culminating in the retrieval of numerous mature oocytes and the development of multiple viable embryos via c-IVF, ultimately leading to successful live births post-embryo transfer. Conclusions: Our study suggests that the outlined COS protocol may serve as a viable treatment option for ROS patients aspiring to conceive through c-IVF, thereby potentially expanding the therapeutic repertoire for this challenging condition.

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The live birth in a woman with resistant ovary syndrome after in vitro oocyte maturation and preimplantation genetic testing for aneuploidy

Cited by 10 publications

References 24 publications

Rescue in vitro maturation may increase the pregnancy outcomes among women undergoing intracytoplasmic sperm injection

Rescue in vitro maturation may increase the pregnancy outcomes among women undergoing intracytoplasmic sperm injection

Resistant ovary syndrome: Pathogenesis and management strategies

Resistant ovary syndrome: Two case reports and a literature review of effective controlled ovarian stimulation in IVF

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