“The little sister” — a tale of Arabia

Peters, W.

doi:10.1016/0035-9203(88)90400-2

Cited by 20 publications

(5 citation statements)

References 25 publications

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“…Exact features of CL depend on the parasite species and the host immune status . Studies done in the past have demonstrated the attitude towards CL lesions and the resultant scars as either sinister or as just a part of life . In Kabul, Afghanistan, girls with CL scars were considered unsuitable for marriage, and women with active lesions were inhibited from doing their daily chores …”

Section: Introductionmentioning

confidence: 99%

Cutaneous leishmaniasis in Sri Lanka: effect on quality of life

Refai¹,

Madarasingha²,

Sumanasena³

et al. 2018

Int J Dermatology

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Background: The quality of life in many patients is affected by skin lesions. Cutaneous leishmaniasis (CL), the commonest form of leishmaniasis is no exception. In Sri Lanka CL is an emerging parasitological condition with over 3000 cases within the last decade. Lesions are often seen on exposed parts of the body which may cause social stigma and hence a study was done to assess the changes in quality of life of CL patients. Method: A total of 294 patients (200 civilians and 94 army personnel) answered a previously validated Sinhala self- administered Dermatology Life Quality Index (DLQI) questionnaire and an interviewer administered questionnaire. Results: The majority of the civilian population 47% had no effect on their quality of life due to CL lesions, 33.5% were affected in a small way,12.5% were affected moderately, 6.5 % suffered in a large way and on 0.5% or one patient was extremely affected due a large ulcerative lesion being on the face. The effect on quality of life was negligible in the majority of army patients as well (35.1%-no effect, 31.9%-small effect), with a few patients affected moderately and very largely (22.3 % and 10.6%) respectively. The most affected domain in patients was symptoms and feeling 1.27±1.400 (mean±SD) and the least was the relationships domain 0.27±0.625. Conclusion: CL does not seem to affect the quality of life in the majority of Sri Lankan patients as compared to CL in other parts of the world or other skin diseases.

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Section: Introductionmentioning

confidence: 99%

Cutaneous leishmaniasis in Sri Lanka: effect on quality of life

Refai¹,

Madarasingha²,

Sumanasena³

et al. 2018

Int J Dermatology

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“…Siage, working in Damascus in the early 1960s, mentioned that the villagers tended to ignore the lesions because they are indolent, and "the scars are not usually feared" [7]. Peters, in his 1988 paper on CL in the Arabian Peninsula, mentions that this disease "was simply accepted as a fact of life" [8]. By contrast, in a report on the incidence of CL in Aleppo, Ashford et al stated that, "Infection is most important as a public health problem in teenagers and young adults, for whom the cosmetic effects are often considered very serious" [9].…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitudes and practices about leishmaniasis among cutaneous leishmaniasis patients in Aleppo, Syrian Arab Republic

Abazid¹,

Jones²,

Davies³

2012

East Mediterr Health J

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“…An opportunistic, intracellular, obligatory protozoan parasite mostly lives in the host's mononuclear phagocytes (WHO, 2010; Clem, 2010; Romero et al, 2009). The parasite was first identified by Cunninghan (1885) and described by Charles Donovan (1903) and William Leishman (1900) (Peters, 1988). A neglected tropical illness called leishmaniasis is being spread by female sandflies of the genera Lutzomyia (new world) and Phlebotomus (old world) (Mann et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Leishmania species: A narrative review on surface proteins with structural aspects involved in host–pathogen interaction

et al. 2023

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In tropical and subtropical regions of the world, leishmaniasis is endemic and causes a range of clinical symptoms in people, from severe tegumentary forms (such as cutaneous, mucocutaneous, and diffuse leishmaniasis) to lethal visceral forms. The protozoan parasite of the genus Leishmania causes leishmaniasis, which is still a significant public health issue, according to the World Health Organization 2022. The public's worry about the neglected tropical disease is growing as new foci of the illness arise, which are exacerbated by alterations in behavior, changes in the environment, and an enlarged range of sand fly vectors. Leishmania research has advanced significantly during the past three decades in a few different avenues. Despite several studies on Leishmania, many issues, such as illness control, parasite resistance, parasite clearance, etc., remain unresolved. The key virulence variables that play a role in the pathogenicity‐host‐pathogen relationship of the parasite are comprehensively discussed in this paper. The important Leishmania virulence factors, such as Kinetoplastid Membrane Protein–11 (KMP‐11), Leishmanolysin (GP63), Proteophosphoglycan (PPG), Lipophosphoglycan (LPG), Glycosylinositol Phospholipids (GIPL), and others, have an impact on the pathophysiology of the disease and enable the parasite to spread the infection. Leishmania infection may arise from virulence factors; they are treatable with medications or vaccinations more promptly and might greatly shorten the duration of treatment. Additionally, our research sought to present a modeled structure of a few putative virulence factors that might aid in the development of new chemotherapeutic approaches for the treatment of leishmaniasis. The predicted virulence protein's structure is utilized to design novel drugs, therapeutic targets, and immunizations for considerable advantage from a higher understanding of the host immune response.

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“The little sister” — a tale of Arabia

Cited by 20 publications

References 25 publications

Cutaneous leishmaniasis in Sri Lanka: effect on quality of life

Cutaneous leishmaniasis in Sri Lanka: effect on quality of life

Knowledge, attitudes and practices about leishmaniasis among cutaneous leishmaniasis patients in Aleppo, Syrian Arab Republic

Leishmania species: A narrative review on surface proteins with structural aspects involved in host–pathogen interaction

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