The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis
Trevor Griesman,
Cynthia M. McMillen,
Seble Getenet Negatu
et al.
Abstract:Rift Valley fever virus (RVFV) is an encephalitic bunyavirus that can infect neurons in the brain. There are no approved therapeutics that can protect from RVFV encephalitis. Innate immunity, the first line of defense against infection, canonically antagonizes viruses through interferon signaling. We found that interferons did not efficiently protect primary cortical neurons from RVFV, unlike other cell types. To identify alternative neuronal antiviral pathways, we screened innate immune ligands and discovered… Show more
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