The Link between Serum Vitamin D Level, Sensitization to Food Allergens, and the Severity of Atopic Dermatitis in Infancy

Baek, Ji Hyeon; Shin, Youn Ho; Chung, In Hyuk; Kim, Hae Jung; Yoo, Eun-Gyong; Yoon, Jung Won; Jee, Hye Mi; Chang, Young Eun; Han, Man Yong

doi:10.1016/j.jpeds.2014.06.058

Cited by 90 publications

(80 citation statements)

References 34 publications

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“…In 2011, Sharief et al [45] reported from the NHANES database of over 3000 children and adolescents that VDD was associated with allergic sensitization to selected foods. A smaller Korean study [46] also suggested that VDD was associated with increased risk of food allergen sensitization. Meanwhile, Allen et al reported from the HealthNuts Study, a large prospective cohort of Australian infants, that children with 25OHD <50 nmol/l at 12 months were more likely to have challenge-proven food allergy but only among infants of Australianborn parents (suggesting a gene-environmental interaction) [47,48 & ].…”

Section: Evidence For a Role Of Vitamin D In Food Allergymentioning

confidence: 94%

Sunlight, vitamin D and food allergy

Rudders

Camargo

2015

Current Opinion in Allergy &Amp; Clinical Immunology

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Section: Evidence For a Role Of Vitamin D In Food Allergymentioning

confidence: 94%

Sunlight, vitamin D and food allergy

Rudders

Camargo

2015

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Another Korean study found significant relationship between 25(OH)D levels and the number and degree of food sensitisation and eczema severity. 29 Vitamin D deficiency also increased the risk of sensitization to food allergens.…”

Section: What Is New In Allergy Prevention That Could Impact On Hong mentioning

confidence: 99%

The unmet provision of allergy services in Hong Kong impairs capability for allergy prevention – implications for the Asia Pacific region

Lee

Leung

Wong

et al. 2017

Asian Pac J Allergy Immunol

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There is a high and rising prevalence of many allergic diseases in the Asia Pacific, including Hong Kong, which is unmatched by a commensurate provision of clinical allergy services. In the last 3 years, the allergy profile in Hong Kong has increased due to greater public engagement and more frequent educational activities, scientific outputs and publication of local guidelines on allergy prevention, diagnosis and treatment. Two new drug allergy clinics have been established in public hospitals, and for the first time in 20 years, Hong Kong has its first trainee in adult allergy. The current ratio of allergists per head of population has improved slightly from 1:1.46 (in 2014) to 1:1.17 million, but it is still low compared to many countries. The Hong Kong community is well supported by allergy-related professional societies and patient organisations. While the recent developments indicated some progress, Hong Kong remains inadequately equipped to take advantage of the new discoveries that may prevent allergic diseases and improve public health. There are also 5-fold more paediatric allergists than adult allergists per head of population. If this unbalance remains uncorrected, continuing care for allergic children as they grow into adulthood will be an increasing problem. This review provides recommendations to improve allergy service provision and training, including the creation of Centres of Excellence in allergy to drive the growth of this specialty.

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“…Sensitization to food allergen is a precursor and a risk factor for the development of allergic diseases later in life, which is why earliest possible detection and modification of risk indicators for food allergen sensitization might prevent the development of allergic diseases [27][28][29].…”

Section: Association Of Allergic Sensitization and Vitamin Dmentioning

confidence: 99%

“…Second, injury of the skin barrier function [26,29,31]. Several recent studies have shown that infants with high level of sensitization had a decreased concentration of 25(OH)D levels [27,29,37]. What is more, the severity of atopic dermatitis was independently influenced by the serum 25(OH)D levels and by food allergen sensitization.…”

Section: Vitamin D and Atopic Dermatitismentioning

confidence: 99%

Immunomodulatory Effect of Vitamin D in Children with Allergic Diseases

Stelmach¹,

Jerzyńska²,

Podlecka³

2017

A Critical Evaluation of Vitamin D - Basic Overview

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The discovery that many cells express vitamin D receptors and the recognition of widespread vitamin D insufficiency has stimulated interest in the potential role of vitamin D in nonskeleton conditions. There is an increasing evidence to support the role of vitamin D pathway in the regulation of the function of both innate and adoptive immune systems. Vitamin D regulates immune function by inhibiting the differentiation and maturation of human dendritic cells, enhancing interleukin (IL)-10 and tumor growth factor-β (TGF-β) secretion and inhibiting T-cell functions. Vitamin D has the ability to suppress inflammatory cytokines, such as tumor necrosis factor (TNF), interleukin-1 (IL-1), interferon gamma (IFN-γ), and interleukin-2 (IL-2), while it increases the generation of anti-inflammatory cytokines IL-4 and IL-10. In B cells, vitamin D3 has also been shown to suppress immunoglobulin E (IgE) antibody class switch partly through the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).

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The Link between Serum Vitamin D Level, Sensitization to Food Allergens, and the Severity of Atopic Dermatitis in Infancy

Cited by 90 publications

References 34 publications

Sunlight, vitamin D and food allergy

Sunlight, vitamin D and food allergy

The unmet provision of allergy services in Hong Kong impairs capability for allergy prevention – implications for the Asia Pacific region

Immunomodulatory Effect of Vitamin D in Children with Allergic Diseases

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