The Link between Serum Omentin Level and Insulin Resistance Biomarkers, Lipid Profile, and Atherogenic Indices in Iraqi Obese Patients.

Osteoarthritis (OA) is not an autoimmune but a chronic inflammatory disease affecting the joints of humans due to mechanical stress mostly in the knees and the hip. In OA a modification of the cartilage is encountered causing a pain in the joints upon movement. Coll2-1NO2 is a specific sequence of amino acids produced from the degradation of type II collagen, which is abundantly found in the cartilage, followed by a nitration in the tyrosine residue as a consequence of stress-inflammatory events. In this study, Coll2-1NO2 is used as a biomarker of OA to predict the inflammatory stress condition as well as the cartilage degradation in pre- and post-menopausal women. The results showed a significant increase of serum Coll2-1NO2 in pre- and post-menopausal women with OA compared to pre- and post-menopausal health women, at similar body mass index category (overweight). Pearson’s correlation analysis showed non-significant association between Coll2-1NO2 and other studied parameters. Moreover, ROC analysis showed a very excellent sensitivity of Coll2-1NO2 as a prognostic biomarker for OA disease in pre- and post-menopausal women

Section: Resultssupporting

confidence: 55%

Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis

Ghanim,

Hasan

2024

“…The only cells in the body that are designed to securely store significant amounts of fat are the fat cells of adipose tissue. Adipose tissues (mainly white adipose tissue) are distributed in the subcutaneous fat (located under the skin) and the visceral fat (located intra-abdominally, adjacent to internal organs) 7 . When excessive amounts of nutrients are consumed, the fat tends to build up in the visceral and subcutaneous depots, enlarging these depots through adipocyte cell hypertrophy and hyperplasia, and making them unhealthy 8 .…”

Section: Introductionmentioning

confidence: 99%

دراسة دور الهيم اوكسجينيز-1 في المرضى الذين يعانون من السمنة

Mohammed,

Khaleel

2024

Heme oxygenase-1(HO-1) is an enzyme that catalyzes and breaks down heme molecules into biliverdin, free iron, bilirubin, and carbon monoxide. This study aims to investigate the levels and role of (HO-1) in obese patients against oxidative stress and its relationship to obesity. The study included 139 samples: (84 obese and 55 non-obese persons). Both study groups were divided into four groups based on their Body Mass Index (BMI). Blood sample was collected from obese persons and control groups (men and women) at AL-Yarmouk Hospital and the National Diabetes Research Center at the period between December-2022 until June-2023. Some biochemical parameters were measured for all studied groups, which include: Determining of HO-1 levels in serum by using the ELISA-technique, lipid profile and fasting serum glucose (FSG) assessed enzymatic. BMI levels were found to be increased significantly in obesity class II group, obesity-class I group, and overweight group compared with normal weight groups. Also, the results showed that waist hip ratio (WHR (was significantly increased (p≤ 0.05) in groups obesity class II, obesity class I, and overweight group compared with normal weight group. Also, the results showed that the HO-1 levels were higher in obese-class I patients and obese-class II group compared with normal-weight and overweight groups. The statistical analysis displayed that, the level of HO-1 is associated negatively with BMI in normal weight group (G1), while positively with the obesity-class II, obesity-class I, and overweight groups. We conclude from this study that the body's first line of defense against oxidative stress attack is HO-1. This cell-protective enzyme reduces oxidative stress and is vital for controlling lipogenesis, which is crucial for the development of metabolic diseases and its complications.

“…But no one provides a precise explanation of the process that underlies obesity. The significance of genetics in obesity has been clearly shown by research on ethnic prevalence, family aggregation, twins and adoption 1,2 . The etiopathology of obesity has been linked to a number of risk factors, including both genetic and environmental ones 3 .…”

Section: Introductionmentioning

confidence: 99%

An Assessment of Heme Oxygenase-1 and Glutathione-S-transferase in Obese Iraqi Patients

Mohammed,

Khaleel

2024

This study aimed to detect the relation of Heme oxygenase-1(HO-1) and Glutathione-S-transferase (GST) in obese patients, against oxidative stress. The study included 139 samples of people with age range of 35-65 years divided in two groups according gender (female and male) groups while four gropes according body mass index (BMI). Blood samples were collected from AL-Yarmouk Hospital at the period between September/2022 to January/2023. Some biochemical parameters were measured for all study groups, which include: -determination of serum HO-1 levels by using the ELISA-technique, lipid profile, GST activity, and fasting serum glucose (FSG) assessed manual. The BMI, waist hip ratio(WHR) and low density lipoprotein (LDL) were found to be significant [(38.83±0.44b) (32.03±0.26a) (26.40±0.22d) (23.10±0.28c)],,[(1.01±0.03b) (0.92±0.02ab) (0.93±0.01ab) (0.88±0.01a)] ,[(80,42±7.47a) (99.74±6.63ab) (112.93±10.12b) (83.94±8.95ab)] respectively and not significant with other parameters of lipid profile, FSG, and Atherogenic index. Also, it appeared that the HO-1 levels were higher in obese groups compared with healthy groups [(2.06 ± 0.09b)(1.95 ± 0.04ab) (1.88 ± 0.04ab)(1.75 ± 0.05a)] ng/ml respectively . It was shown that the increasing of GST level in healthy compared with obese groups [(6.10± 0.57c)(4.120 ± 0.69b)(2.44 ± 0.21a)(2.71± 0.30ab)]IU/L respectively .The result showed that the increase in BMI,WHR and HO-1 in obese female and BMI,TG,HO-1 and VLDL in obese male ,compared with female and male healthy groups ,while the results showed an increase in GST levels in healthy female and male groups .We conclude from this study that high levels of heme oxygen-1 synchronized with low of glutathione-S- transferase , clearly indicating their primary role in detoxification, protection of the against oxidative stress, and prevention of the development of metabolic diseases.