The Link between Potassium and Mild Cognitive Impairment in Mexican-Americans

Vintimilla, Raul; Large, Stephanie; Gamboa, Adriana C.; Rohlfing, Geoffrey; O'Jile, Judith Rosemary; Hall, James; O'Bryant, Sidney; Johnson, Leigh A.

doi:10.1159/000488483

Cited by 17 publications

(16 citation statements)

References 35 publications

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“…These findings contradict our premise of lower potassium levels www.kjcls.org that are related to MCI status. A plausible explanation may be the different socioeconomic status and biological components in our population [24].…”

Section: Discussionmentioning

confidence: 93%

Influences of the Global Deterioration Scale according to Routine Blood Chemistry Results

Kim¹,

Park

2019

Korean J Clin Lab Sci.

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Neurocognitive testing commonly uses the MMSE (Mini-Mental State Examination) to evaluate the overall cognitive function of patients at outpatient clinics, but the MMSE has recently been extensively used in the SNSB II (Seoul Neuropsychological Screening Battery II) for making diagnoses. We retrospectively investigated the results of routine neurocognitive tests and the results of the blood tests of 120 elderly patients who had been referred to a South Central Medical Center from 2017 to 2018 and who had been examined at a public health center. These subjects' space-time capability was high on the sub-region of the global deterioration scale (GDS). GDS showed a significant increase as the Na decreased on the electrolyte analysis. The subjects' concentration, their language-based orientation for space and time, their memory, and their scores for the frontal lobe function on GDS showed statistically significant reductions (P＜0.001) For the normal and abnormal groups according to the ALT and creatinine levels, the frontal/execute function areas showed statistically significant differences (P＜0.001) as well as negative correlation between GDS and ALT (P＜0.01). In conclusion, this study provides basic information to develop test items that are important for patient screening and diagnosis, and several routine blood chemistry factors provide basic information for diagnosing and assessing the status and progress of cognitively impaired patients.

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Section: Discussionmentioning

confidence: 93%

Influences of the Global Deterioration Scale according to Routine Blood Chemistry Results

Kim¹,

Park

2019

Korean J Clin Lab Sci.

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“…Previous research has also found that high serum potassium levels were associated with mild cognitive impairment (Vintimilla et al, 2018), while high glucose levels were associated with low gray matter density and FA (Weinstein et al, 2015). Higher GT levels, as an index of liver function, has previously been associated with brain volume shrinkage in patients with alcohol dependence (Chen et al, 2012), brain infarcts in a healthy population (Nam et al, 2019), and cardiovascular mortality (Ruttmann et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Cardiometabolic risk factors associated with brain age and accelerate brain ageing

Beck

Lange

Pedersen

et al. 2021

Preprint

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The structure and integrity of the ageing brain is interchangeably linked to physical health, and cardiometabolic risk factors (CMRs) are associated with dementia and other brain disorders. In this mixed cross-sectional and longitudinal study (interval mean [standard deviation] = 19.7 [0.5] months), including 1062 datasets from 790 healthy individuals (mean (range) age = 46.7 (18-94) years, 54% women), we investigated CMRs and health indicators including anthropometric measures, lifestyle factors, and blood biomarkers in relation to brain structure using MRI-based morphometry and diffusion tensor imaging (DTI). We performed tissue specific brain age prediction using machine learning and performed Bayesian multilevel modelling to assess changes in each CMR over time, their respective association with brain age gap (BAG), and their interaction effects with time and age on the tissue-specific BAGs. The results showed credible associations between DTI-based BAG and blood levels of phosphate and mean cell volume (MCV), and between T1-based BAG and systolic blood pressure, smoking, pulse, and C-reactive protein (CRP), indicating older-appearing brains in people with higher cardiometabolic risk (smoking, higher blood pressure and pulse, low-grade inflammation). Longitudinal evidence supported interactions between both BAGs and waist-to-hip ratio (WHR), and between DTI-based BAG and systolic blood pressure and smoking, indicating accelerated ageing in people with higher cardiometabolic risk (smoking, higher blood pressure, and WHR). The results demonstrate that cardiometabolic risk factors are associated with brain ageing. While randomised controlled trials are needed to establish causality, our results indicate that public health initiatives and treatment strategies targeting modifiable cardiometabolic risk factors may also improve risk trajectories and delay brain ageing. Key words: T1 MRI, DTI, Brain age, Cardiometabolic risk

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“…In the case of acute cognitive deficits, the dysphagia clinician should consider the patient's prior level of cognitive function and the likelihood that the cognitive function will return after the acute event is resolved. For example, individuals with acute electrolyte abnormalities may have acute cognitive deficits that are likely to resolve once the electrolyte balance is restored (Vintimilla et al, 2018). The dysphagia clinician must determine a patient's safety and available support during this period of altered cognition and attend to the impact on daily eating and oral care routines.…”

Section: General Healthmentioning

confidence: 99%

Risk of an Adverse Event in Individuals Who Aspirate: A Review of Current Literature on Host Defenses and Individual Differences

Palmer

Padilla

2022

Am J Speech Lang Pathol

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Purpose The presence of oropharyngeal dysphagia increases the likelihood of prandial aspiration, and aspiration increases the likelihood of a dysphagia-related pulmonary sequelae such as aspiration pneumonia, acute respiratory distress syndrome, pulmonary fibrosis, and even death. Although these outcomes are unfortunate, it is important to point out that these consequences are not solely determined by the presence of aspiration. The purpose of this tutorial is to provide current information on pulmonary defenses and the variables that increase risk of an adverse outcome in individuals who aspirate. Method This tutorial reviews the basics of lung defenses and summarizes the literature to make the case that the host is a central theme in dysphagia management. Case studies are employed to highlight the key variables. Results Based on a literature review, a series of questions are proposed for consideration in dysphagia management. These questions, which take the focus away from the presence of aspiration and toward the associated risks within an individual, are then applied to two case studies. Conclusions A guiding framework is proposed to encourage clinicians to assess more than the presence of aspiration and consider the individual's ability to cope with the aspirated material. In the presence of aspiration, clinicians are urged to focus on the risk factors that can lead to a negative consequence, identify which factors are modifiable, and determine when a level of risk is acceptable.

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The Link between Potassium and Mild Cognitive Impairment in Mexican-Americans

Cited by 17 publications

References 35 publications

Influences of the Global Deterioration Scale according to Routine Blood Chemistry Results

Influences of the Global Deterioration Scale according to Routine Blood Chemistry Results

Cardiometabolic risk factors associated with brain age and accelerate brain ageing

Risk of an Adverse Event in Individuals Who Aspirate: A Review of Current Literature on Host Defenses and Individual Differences

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