The link between pharmaceuticals and cyanobacteria: a review regarding ecotoxicological, ecological, and sanitary aspects

Costa, Rafaela dos Santos; Quadra, Gabrielle Rabelo; Souza, Helena de Oliveira; Amaral, Viviane Souza do; Navoni, Júlio Alejandro

doi:10.1007/s11356-021-14698-5

Cited by 7 publications

(3 citation statements)

References 113 publications

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“…22−24 In common aquatic environments; however, CLA concentrations range from ng/L to μg/L and largely remain below 100 μg/L. 25,26 Test concentrations of 0−100 μg/L have been widely used in previous studies. 10,16,27,28 In this experiment, different volumes of CLA standard were added to the 600 mL M. aeruginosa suspension to yield final concentrations of 0, 5, 10, 20, 40, 60, 80, and 100 μg/L (control, CLA-5, CLA-10, CLA-20, CLA-40, CLA-60, CLA-80, and CLA-100).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…In actual aquatic environments, CLA can be detected over a broad range of concentrations. For example, extremely high levels of CLA have been observed in hospital effluents (322,735 ng/L) and WWTP influent (tens of mg/L). − In common aquatic environments; however, CLA concentrations range from ng/L to μg/L and largely remain below 100 μg/L. , Test concentrations of 0–100 μg/L have been widely used in previous studies. ,,, In this experiment, different volumes of CLA standard were added to the 600 mL M. aeruginosa suspension to yield final concentrations of 0, 5, 10, 20, 40, 60, 80, and 100 μg/L (control, CLA-5, CLA-10, CLA-20, CLA-40, CLA-60, CLA-80, and CLA-100).…”

Section: Methodsmentioning

confidence: 99%

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Repeated Exposure Enhanced Toxicity of Clarithromycin on Microcystis aeruginosa Versus Single Exposure through Photosynthesis, Oxidative Stress, and Energy Metabolism Shift

Mao,

Ye,

Yang

et al. 2024

Environ. Sci. Technol.

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Antibiotics are being increasingly detected in aquatic environments, and their potential ecological risk is of great concern. However, most antibiotic toxicity studies involve single-exposure experiments. Herein, we studied the effects and mechanisms of repeated versus single clarithromycin (CLA) exposure on Microcystis aeruginosa. The 96 h effective concentration of CLA was 13.37 μg/L upon single exposure but it reduced to 6.90 μg/L upon repeated exposure. Single-exposure CLA inhibited algal photosynthesis by disrupting energy absorption, dissipation and trapping, reaction center activation, and electron transport, thereby inducing oxidative stress and ultrastructural damage. In addition, CLA upregulated glycolysis, pyruvate metabolism, and the tricarboxylic acid cycle. Repeated exposure caused stronger inhibition of algal growth via altering photosynthetic pigments, reaction center subunits biosynthesis, and electron transport, thereby inducing more substantial oxidative damage. Furthermore, repeated exposure reduced carbohydrate utilization by blocking the pentose phosphate pathway, consequently altering the characteristics of extracellular polymeric substances and eventually impairing the defense mechanisms of M. aeruginosa. Risk quotients calculated from repeated exposure were higher than 1, indicating significant ecological risks. This study elucidated the strong influence of repeated antibiotic exposure on algae, providing new insight into antibiotic risk assessment.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Repeated Exposure Enhanced Toxicity of Clarithromycin on Microcystis aeruginosa Versus Single Exposure through Photosynthesis, Oxidative Stress, and Energy Metabolism Shift

Mao,

Ye,

Yang

et al. 2024

Environ. Sci. Technol.

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“…Pharmaceutical contamination has gained prominence due to its adverse ecological effects (Rzymski et al, 2017), such as feminization and behavioral change in fish (Thrupp et al, 2018), inhibition of cyanobacterial growth (Costa et al, 2021), among others. One of the sources of pharmaceuticals entering the environment is the lack of technologies for their removal in wastewater treatment plants in several countries, such as Brazil (Marson et al, 2022).…”

Section: The Practices Of Brazilian Internet Users On the Environment...mentioning

confidence: 99%

The practices of Brazilian internet users on the environmental impacts associated with the use of medicines in the COVID-19 pandemic: are we practicing ecopharmacovigilance?

Costa,

Medeiros,

Amaral

et al. 2023

Rev. Bras. Ciênc. Ambient.

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Pharmaceutical contamination represents an environmental and public health threat. One of the sources of entry of these compounds into the environment is the disposal of expired or unused medicines. However, it is necessary to understand how the population recognize this problem to subsidize management actions on this theme. Mitigating and/or reducing the entry of pharmaceuticals into the environment is one of the main lines of action of the ecopharmacovigilance (EPV). Thus, the present study aimed to analyze the environmental habits of medicines disposal by Brazilian web users, in accordance with current legislation, as well as the environmental impacts resulting from pharmacological contamination, during the COVID-19 pandemic, besides evaluating the implementation of the EPV concept. An online questionnaire was developed on the Google Forms platform with 26 questions, and was disseminated for six months on social networks, websites, and emails. The sampling method used was the convenience. The results indicated the predominance of consumption of the pharmacological group associated with COVID-19 treatment. In addition, it was observed that most participants discarded medicines for human (62.0%) and veterinary (33.6%) use in common waste. Moreover, there was a concern among respondents regarding the occurrence of pharmaceuticals in the environment and their implications in different environmental matrices as well as in human health. Disseminating the current Brazilian legislation and improving the effectiveness of reverse logistics programs, as well as making society aware of the impacts associated with pharmaceuticals can help mitigate this environmental problem.

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The growth, biochemical composition, and antioxidant response of Microcystis and Chlorella are influenced by Ibuprofen

Sha’aba

Chia²,

Gana³

et al. 2022

Environ Sci Pollut Res

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The link between pharmaceuticals and cyanobacteria: a review regarding ecotoxicological, ecological, and sanitary aspects

Cited by 7 publications

References 113 publications

Repeated Exposure Enhanced Toxicity of Clarithromycin on Microcystis aeruginosa Versus Single Exposure through Photosynthesis, Oxidative Stress, and Energy Metabolism Shift

Repeated Exposure Enhanced Toxicity of Clarithromycin on Microcystis aeruginosa Versus Single Exposure through Photosynthesis, Oxidative Stress, and Energy Metabolism Shift

The practices of Brazilian internet users on the environmental impacts associated with the use of medicines in the COVID-19 pandemic: are we practicing ecopharmacovigilance?

The growth, biochemical composition, and antioxidant response of Microcystis and Chlorella are influenced by Ibuprofen

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